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Protein

Synaptoporin

Gene

Synpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).By similarity

Protein family/group databases

TCDBi9.B.130.1.1 the tetraspan vesicle membrane protein (tvp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptoporin
Gene namesi
Name:Synpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1919253 Synpr

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 81VesicularSequence analysisAdd BLAST56
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 114CytoplasmicSequence analysisAdd BLAST12
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 177VesicularSequence analysisAdd BLAST42
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 265CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791581 – 265SynaptoporinAdd BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei212PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BGN8
PeptideAtlasiQ8BGN8
PRIDEiQ8BGN8

PTM databases

iPTMnetiQ8BGN8
PhosphoSitePlusiQ8BGN8

Expressioni

Gene expression databases

BgeeiENSMUSG00000056296 Expressed in 160 organ(s), highest expression level in olfactory bulb
CleanExiMM_SYNPR
ExpressionAtlasiQ8BGN8 baseline and differential
GenevisibleiQ8BGN8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064986

Structurei

3D structure databases

ProteinModelPortaliQ8BGN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 202MARVELPROSITE-ProRule annotationAdd BLAST202
Repeati210 – 21415
Repeati222 – 22625
Repeati227 – 23135
Repeati232 – 23645
Repeati238 – 24255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 2425 X approximate repeatsAdd BLAST33

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYC Eukaryota
ENOG4111J4N LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiQ8BGN8
OMAiCEGKRRE
OrthoDBiEOG091G0ZEI
PhylomeDBiQ8BGN8
TreeFamiTF315804

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
PS00604 SYNAPTOP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BGN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCMVIFAPLF AMFAFATCGG YSGGLRLSVD CVNKTESNLS IDIAFAYPFR
60 70 80 90 100
LQQVTFEVPT CEGKEQQKLA LVGDSSSSAE FFVTVAVFAF LYSLAATVVY
110 120 130 140 150
IFFQNKYREN NRGPLIDFIV TVVFSFLWLV GSSAWAKGLS DVKVATDPKE
160 170 180 190 200
VLLLMSACKQ PSNKCMAVHS PVMSSLNTSV VFGFLNFILW AGNIWFVFKE
210 220 230 240 250
TGWHSSGQRY LSDPMEKHSS SYNQGRYNQE SYGSSGGYSQ QANLGPTSDE
260
FGQQPSGPTS FNNQI
Length:265
Mass (Da):29,228
Last modified:March 1, 2003 - v1
Checksum:i81DD473A422815E5
GO
Isoform 2 (identifier: Q8BGN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MCMVIFAP → MDPVSQVASAGTFRALKEPLAFLRALEL

Show »
Length:285
Mass (Da):31,349
Checksum:iF3A7B5DE24A3B739
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z5Q8D3Z5Q8_MOUSE
Synaptoporin
Synpr
125Annotation score:
A0A286YDB6A0A286YDB6_MOUSE
Synaptoporin
Synpr
325Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230E → K in BAC37181 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0085501 – 8MCMVIFAP → MDPVSQVASAGTFRALKEPL AFLRALEL in isoform 2. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005132 mRNA Translation: BAB23831.1
AK032442 mRNA Translation: BAC27871.1
AK049661 mRNA Translation: BAC33864.1
AK078223 mRNA Translation: BAC37181.1
BC026512 mRNA Translation: AAH26512.1
CCDSiCCDS26821.1 [Q8BGN8-2]
CCDS49402.1 [Q8BGN8-1]
RefSeqiNP_001156504.1, NM_001163032.1 [Q8BGN8-1]
NP_082328.3, NM_028052.4 [Q8BGN8-2]
UniGeneiMm.317515

Genome annotation databases

EnsembliENSMUST00000070323; ENSMUSP00000064986; ENSMUSG00000056296 [Q8BGN8-2]
ENSMUST00000112656; ENSMUSP00000108275; ENSMUSG00000056296 [Q8BGN8-1]
GeneIDi72003
KEGGimmu:72003
UCSCiuc007sfy.2 mouse [Q8BGN8-2]
uc007sga.2 mouse [Q8BGN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005132 mRNA Translation: BAB23831.1
AK032442 mRNA Translation: BAC27871.1
AK049661 mRNA Translation: BAC33864.1
AK078223 mRNA Translation: BAC37181.1
BC026512 mRNA Translation: AAH26512.1
CCDSiCCDS26821.1 [Q8BGN8-2]
CCDS49402.1 [Q8BGN8-1]
RefSeqiNP_001156504.1, NM_001163032.1 [Q8BGN8-1]
NP_082328.3, NM_028052.4 [Q8BGN8-2]
UniGeneiMm.317515

3D structure databases

ProteinModelPortaliQ8BGN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064986

Protein family/group databases

TCDBi9.B.130.1.1 the tetraspan vesicle membrane protein (tvp) family

PTM databases

iPTMnetiQ8BGN8
PhosphoSitePlusiQ8BGN8

Proteomic databases

PaxDbiQ8BGN8
PeptideAtlasiQ8BGN8
PRIDEiQ8BGN8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070323; ENSMUSP00000064986; ENSMUSG00000056296 [Q8BGN8-2]
ENSMUST00000112656; ENSMUSP00000108275; ENSMUSG00000056296 [Q8BGN8-1]
GeneIDi72003
KEGGimmu:72003
UCSCiuc007sfy.2 mouse [Q8BGN8-2]
uc007sga.2 mouse [Q8BGN8-1]

Organism-specific databases

CTDi132204
MGIiMGI:1919253 Synpr

Phylogenomic databases

eggNOGiENOG410IDYC Eukaryota
ENOG4111J4N LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiQ8BGN8
OMAiCEGKRRE
OrthoDBiEOG091G0ZEI
PhylomeDBiQ8BGN8
TreeFamiTF315804

Miscellaneous databases

ChiTaRSiSynpr mouse
PROiPR:Q8BGN8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056296 Expressed in 160 organ(s), highest expression level in olfactory bulb
CleanExiMM_SYNPR
ExpressionAtlasiQ8BGN8 baseline and differential
GenevisibleiQ8BGN8 MM

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
PS00604 SYNAPTOP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYNPR_MOUSE
AccessioniPrimary (citable) accession number: Q8BGN8
Secondary accession number(s): Q8C5J4, Q9DB89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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