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Protein

Bestrophin-2

Gene

Best2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.1 Publication

GO - Molecular functioni

  • chloride channel activity Source: MGI

GO - Biological processi

  • chloride transmembrane transport Source: BHF-UCL
  • chloride transport Source: MGI
  • membrane depolarization Source: HGNC
  • sensory perception of smell Source: HGNC

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandCalcium, Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Bestrophin-2
Alternative name(s):
Vitelliform macular dystrophy 2-like protein 1
Gene namesi
Name:Best2
Synonyms:Vmd2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2387588 Best2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 70ExtracellularSequence analysisAdd BLAST24
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 178CytoplasmicSequence analysisAdd BLAST87
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 228ExtracellularSequence analysisAdd BLAST29
Intramembranei229 – 249Sequence analysisAdd BLAST21
Topological domaini250 – 270ExtracellularSequence analysisAdd BLAST21
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 508CytoplasmicSequence analysisAdd BLAST217

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431191 – 508Bestrophin-2Add BLAST508

Proteomic databases

PaxDbiQ8BGM5
PRIDEiQ8BGM5

PTM databases

PhosphoSitePlusiQ8BGM5

Expressioni

Tissue specificityi

Mainly confined to the retinal pigment epithelium and colon.

Gene expression databases

CleanExiMM_BEST2

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053408

Structurei

3D structure databases

ProteinModelPortaliQ8BGM5
SMRiQ8BGM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bestrophin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3547 Eukaryota
ENOG410XS3J LUCA
HOGENOMiHOG000115678
HOVERGENiHBG044928
InParanoidiQ8BGM5
KOiK13879
PhylomeDBiQ8BGM5
TreeFamiTF315803

Family and domain databases

InterProiView protein in InterPro
IPR000615 Bestrophin
IPR021134 Bestrophin/UPF0187
PANTHERiPTHR10736 PTHR10736, 1 hit
PfamiView protein in Pfam
PF01062 Bestrophin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BGM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVTYTARVA NARFGGFSQL LLLWRGSIYK LLWRELLCFL GLYMALSAAY
60 70 80 90 100
RFLLAEEQKR YFEKLVIYCD QYASLIPVSF VLGFYVTLVV HRWWNQYLCM
110 120 130 140 150
PLPDALMCIV AGTVHGRDDR GRLYRRTLMR YAGLSAVLIL RSVSTAVFKR
160 170 180 190 200
FPTIDHVVEA GFMTREERKK FENLNSSYNK YWVPCVWFSS LAAQARREGR
210 220 230 240 250
IRDNSALKLL LEELNVFRSK CGMLFHYDWI SIPLVYTQVV TIAVYSYFLA
260 270 280 290 300
CLIGRQFLDP AQGYKDHTLD LCVPIFTLLQ FFFYAGWLKV AEQLINPFGE
310 320 330 340 350
DDDDFETNFL IDRNFQVSML AVDEMYDDLA MLEKDLYWDA AEARAPYTAA
360 370 380 390 400
TAFLLQQPSF QGSTFDIALA KEDMQFQRLD GVDGPLGEVH GDFLQRLLPA
410 420 430 440 450
GAGSVGPLGR RLSLLRRKNS CVSEASTAAS CGCAGAADGG GVECGCGDPL
460 470 480 490 500
LDPSLREPEL EPPACPEPPA PIPGPTPEPF TTVSIPGPRA PAPPWLPSPI

GEEEESPA
Length:508
Mass (Da):57,023
Last modified:March 1, 2003 - v1
Checksum:i8730B806F0576B3D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0P0A0A0R4J0P0_MOUSE
Bestrophin
Best2
508Annotation score:

Sequence cautioni

The sequence AAH19528 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH31186 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH36157 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH36163 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti462P → S in AAS09923 (PubMed:15218265).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY450428 mRNA Translation: AAS09923.1
BC019528 mRNA Translation: AAH19528.1 Different initiation.
BC031186 mRNA Translation: AAH31186.1 Different initiation.
BC036157 mRNA Translation: AAH36157.2 Different initiation.
BC036163 mRNA Translation: AAH36163.2 Different initiation.
CCDSiCCDS52621.1
RefSeqiNP_001123666.1, NM_001130194.1
XP_006530883.1, XM_006530820.1
UniGeneiMm.215154

Genome annotation databases

GeneIDi212989
KEGGimmu:212989
UCSCiuc009mov.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY450428 mRNA Translation: AAS09923.1
BC019528 mRNA Translation: AAH19528.1 Different initiation.
BC031186 mRNA Translation: AAH31186.1 Different initiation.
BC036157 mRNA Translation: AAH36157.2 Different initiation.
BC036163 mRNA Translation: AAH36163.2 Different initiation.
CCDSiCCDS52621.1
RefSeqiNP_001123666.1, NM_001130194.1
XP_006530883.1, XM_006530820.1
UniGeneiMm.215154

3D structure databases

ProteinModelPortaliQ8BGM5
SMRiQ8BGM5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053408

PTM databases

PhosphoSitePlusiQ8BGM5

Proteomic databases

PaxDbiQ8BGM5
PRIDEiQ8BGM5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi212989
KEGGimmu:212989
UCSCiuc009mov.1 mouse

Organism-specific databases

CTDi54831
MGIiMGI:2387588 Best2

Phylogenomic databases

eggNOGiKOG3547 Eukaryota
ENOG410XS3J LUCA
HOGENOMiHOG000115678
HOVERGENiHBG044928
InParanoidiQ8BGM5
KOiK13879
PhylomeDBiQ8BGM5
TreeFamiTF315803

Miscellaneous databases

PROiPR:Q8BGM5
SOURCEiSearch...

Gene expression databases

CleanExiMM_BEST2

Family and domain databases

InterProiView protein in InterPro
IPR000615 Bestrophin
IPR021134 Bestrophin/UPF0187
PANTHERiPTHR10736 PTHR10736, 1 hit
PfamiView protein in Pfam
PF01062 Bestrophin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBEST2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGM5
Secondary accession number(s): Q6H1U9, Q8VCM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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