Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat-containing protein 39

Gene

Lrrc39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.By similarity

Keywordsi

Molecular functionMuscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 39Curated
Alternative name(s):
Myosin-interacting M-band-associated stress-responsive proteinBy similarity
Short name:
MyomaspBy similarity
Gene namesi
Name:Lrrc39Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1924557 Lrrc39

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325811 – 337Leucine-rich repeat-containing protein 39Add BLAST337

Proteomic databases

MaxQBiQ8BGI7
PaxDbiQ8BGI7
PRIDEiQ8BGI7

PTM databases

iPTMnetiQ8BGI7
PhosphoSitePlusiQ8BGI7

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000027961 Expressed in 76 organ(s), highest expression level in quadriceps femoris
CleanExiMM_LRRC39
ExpressionAtlasiQ8BGI7 baseline and differential
GenevisibleiQ8BGI7 MM

Interactioni

Subunit structurei

Interacts with MYH7 (via C-terminus).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029573

Structurei

3D structure databases

ProteinModelPortaliQ8BGI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati84 – 105LRR 1Add BLAST22
Repeati107 – 128LRR 2Add BLAST22
Repeati130 – 152LRR 3Add BLAST23
Repeati153 – 176LRR 4Add BLAST24
Repeati177 – 198LRR 5Add BLAST22
Repeati200 – 221LRR 6Add BLAST22
Repeati223 – 244LRR 7Add BLAST22
Repeati246 – 267LRR 8Add BLAST22
Repeati269 – 290LRR 9Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00840000129686
HOGENOMiHOG000065739
HOVERGENiHBG101376
InParanoidiQ8BGI7
OMAiMHAYIQE
OrthoDBiEOG091G0CW0
PhylomeDBiQ8BGI7
TreeFamiTF333627

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits

Sequencei

Sequence statusi: Complete.

Q8BGI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTESAVCTGA VSAVKEVWEE RIKKHHEDVK REKEFQHKLV RIWEDRVSLT
60 70 80 90 100
KLKEKVTRED GRVILRIEKE EWKTLPSSLL KLNQLQEWQL HRTGLLKIPE
110 120 130 140 150
FIGRFQHLIV LDLSRNTISE IPRGIGLLTR LQELILSYNK IKTVPKELSN
160 170 180 190 200
CTSLEKLELA VNRDISDLPP ELSKLLKLTH LDLSMNQFTT IPHAVLDMPA
210 220 230 240 250
LEWLDMGSNS LQQLPDSLDR MRSLHTLWLQ RNEITCLPET IKNMKNLGTL
260 270 280 290 300
VLSNNKLQDI PGCMEEMTNL RFVNFRDNPL RLEVTLPPSD NTDGEEEQEL
310 320 330
FGLQFMHAYI QESRRTEDQV NCLTQMPSSI HSDGESN
Length:337
Mass (Da):39,061
Last modified:March 1, 2003 - v1
Checksum:i9565978A7716BCD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039277 mRNA Translation: BAC30303.1
AK052159 mRNA Translation: BAC34863.1
AK079125 mRNA Translation: BAC37551.1
CCDSiCCDS17788.1
RefSeqiNP_780622.1, NM_175413.3
UniGeneiMm.216027
Mm.259648

Genome annotation databases

EnsembliENSMUST00000029573; ENSMUSP00000029573; ENSMUSG00000027961
GeneIDi109245
KEGGimmu:109245
UCSCiuc008rci.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039277 mRNA Translation: BAC30303.1
AK052159 mRNA Translation: BAC34863.1
AK079125 mRNA Translation: BAC37551.1
CCDSiCCDS17788.1
RefSeqiNP_780622.1, NM_175413.3
UniGeneiMm.216027
Mm.259648

3D structure databases

ProteinModelPortaliQ8BGI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029573

PTM databases

iPTMnetiQ8BGI7
PhosphoSitePlusiQ8BGI7

Proteomic databases

MaxQBiQ8BGI7
PaxDbiQ8BGI7
PRIDEiQ8BGI7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029573; ENSMUSP00000029573; ENSMUSG00000027961
GeneIDi109245
KEGGimmu:109245
UCSCiuc008rci.2 mouse

Organism-specific databases

CTDi127495
MGIiMGI:1924557 Lrrc39

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00840000129686
HOGENOMiHOG000065739
HOVERGENiHBG101376
InParanoidiQ8BGI7
OMAiMHAYIQE
OrthoDBiEOG091G0CW0
PhylomeDBiQ8BGI7
TreeFamiTF333627

Miscellaneous databases

PROiPR:Q8BGI7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027961 Expressed in 76 organ(s), highest expression level in quadriceps femoris
CleanExiMM_LRRC39
ExpressionAtlasiQ8BGI7 baseline and differential
GenevisibleiQ8BGI7 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC39_MOUSE
AccessioniPrimary (citable) accession number: Q8BGI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again