Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor expression-enhancing protein 1

Gene

Reep1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 1
Gene namesi
Name:Reep1
Synonyms:D6Ertd253e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1098827 Reep1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018221 – 201Receptor expression-enhancing protein 1Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BGH4
PaxDbiQ8BGH4
PeptideAtlasiQ8BGH4
PRIDEiQ8BGH4

PTM databases

iPTMnetiQ8BGH4
PhosphoSitePlusiQ8BGH4

Expressioni

Tissue specificityi

Detected in olfactory sensory neurons of the olfactory epithelium, and in total brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000052852 Expressed in 266 organ(s), highest expression level in central nervous system
CleanExiMM_REEP1
ExpressionAtlasiQ8BGH4 baseline and differential
GenevisibleiQ8BGH4 MM

Interactioni

Subunit structurei

Interacts with OLFR992 (PubMed:15550249). Interacts with SPAST and ATL1. Interacts (via C-terminus) with microtubules (By similarity). Interacts with ZFYVE27 (PubMed:24668814).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ8BGH4
STRINGi10090.ENSMUSP00000112662

Structurei

3D structure databases

ProteinModelPortaliQ8BGH4
SMRiQ8BGH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 173Poly-Pro4

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1726 Eukaryota
COG5052 LUCA
GeneTreeiENSGT00550000074535
HOGENOMiHOG000007472
HOVERGENiHBG056861
InParanoidiQ8BGH4
KOiK17338
OMAiGILCARE
OrthoDBiEOG091G0X58
PhylomeDBiQ8BGH4
TreeFamiTF314177

Family and domain databases

InterProiView protein in InterPro
IPR004345 TB2_DP1_HVA22
PANTHERiPTHR12300 PTHR12300, 1 hit
PfamiView protein in Pfam
PF03134 TB2_DP1_HVA22, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BGH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSWIISRLV VLIFGTLYPA YYSYKAVKSK DIKEYVKWMM YWIIFALFTT
60 70 80 90 100
AETFTDIFLC WFPFYYELKI AFVAWLLSPY TKGSSLLYRK FVHPTLSSKE
110 120 130 140 150
KEIDDCLVQA KDRSYDALVH FGKRGLNVAA TAAVMAASKG QGALSERLRS
160 170 180 190 200
FSMQDLTTIR GDGAPAPSGP PPPGTGRSSG KHSQPKMSRS ASESAGSSGT

A
Length:201
Mass (Da):22,285
Last modified:March 1, 2003 - v1
Checksum:i99C33D74A71FB6B7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLF1A0A1D5RLF1_MOUSE
Receptor expression-enhancing prote...
Reep1
284Annotation score:
A0A1D5RM91A0A1D5RM91_MOUSE
Receptor expression-enhancing prote...
Reep1
143Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562229 mRNA Translation: AAT70674.1
AK035238 mRNA Translation: BAC28995.1
AK045056 mRNA Translation: BAC32200.1
AK053158 mRNA Translation: BAC35288.1
AK136916 mRNA Translation: BAE23168.1
BC046826 mRNA Translation: AAH46826.1
CCDSiCCDS51807.1
RefSeqiNP_848723.1, NM_178608.4
UniGeneiMm.146332

Genome annotation databases

EnsembliENSMUST00000121469; ENSMUSP00000112662; ENSMUSG00000052852
GeneIDi52250
KEGGimmu:52250
UCSCiuc009chc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562229 mRNA Translation: AAT70674.1
AK035238 mRNA Translation: BAC28995.1
AK045056 mRNA Translation: BAC32200.1
AK053158 mRNA Translation: BAC35288.1
AK136916 mRNA Translation: BAE23168.1
BC046826 mRNA Translation: AAH46826.1
CCDSiCCDS51807.1
RefSeqiNP_848723.1, NM_178608.4
UniGeneiMm.146332

3D structure databases

ProteinModelPortaliQ8BGH4
SMRiQ8BGH4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ8BGH4
STRINGi10090.ENSMUSP00000112662

PTM databases

iPTMnetiQ8BGH4
PhosphoSitePlusiQ8BGH4

Proteomic databases

MaxQBiQ8BGH4
PaxDbiQ8BGH4
PeptideAtlasiQ8BGH4
PRIDEiQ8BGH4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000121469; ENSMUSP00000112662; ENSMUSG00000052852
GeneIDi52250
KEGGimmu:52250
UCSCiuc009chc.2 mouse

Organism-specific databases

CTDi65055
MGIiMGI:1098827 Reep1

Phylogenomic databases

eggNOGiKOG1726 Eukaryota
COG5052 LUCA
GeneTreeiENSGT00550000074535
HOGENOMiHOG000007472
HOVERGENiHBG056861
InParanoidiQ8BGH4
KOiK17338
OMAiGILCARE
OrthoDBiEOG091G0X58
PhylomeDBiQ8BGH4
TreeFamiTF314177

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Miscellaneous databases

PROiPR:Q8BGH4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052852 Expressed in 266 organ(s), highest expression level in central nervous system
CleanExiMM_REEP1
ExpressionAtlasiQ8BGH4 baseline and differential
GenevisibleiQ8BGH4 MM

Family and domain databases

InterProiView protein in InterPro
IPR004345 TB2_DP1_HVA22
PANTHERiPTHR12300 PTHR12300, 1 hit
PfamiView protein in Pfam
PF03134 TB2_DP1_HVA22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREEP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again