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Entry version 142 (16 Oct 2019)
Sequence version 3 (25 Oct 2005)
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Protein

Fanconi anemia group M protein homolog

Gene

Fancm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi99 – 106ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6783310 Fanconi Anemia Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fanconi anemia group M protein homolog (EC:3.6.4.13By similarity)
Short name:
Protein FACM
Alternative name(s):
ATP-dependent RNA helicase FANCM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fancm
Synonyms:Kiaa1596
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442306 Fancm

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176806

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000551771 – 2021Fanconi anemia group M protein homologAdd BLAST2021

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphoserineBy similarity1
Modified residuei1637PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; hyperphosphorylated in response to genotoxic stress.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BGE5

PRoteomics IDEntifications database

More...
PRIDEi
Q8BGE5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BGE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BGE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000055884 Expressed in 162 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BGE5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BGE5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha/TOP3A, RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. This supercomplex between FA and BLM complexes has been called BRAFT.

Forms a discrete complex with CENPS and CENPX, called FANCM-MHF; this interaction stimulates DNA binding and replication fork remodeling by FANCM and stabilizes the binding partners.

Forms a heterodimer with FAAP24; this interaction increases FANCM single-stranded DNA-binding activity.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
222708, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000054797

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 254Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini437 – 612Helicase C-terminalPROSITE-ProRule annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1689 – 2009Interaction with FAAP24By similarityAdd BLAST321

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi202 – 205DEAH boxPROSITE-ProRule annotation4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0354 Eukaryota
KOG0442 Eukaryota
COG1111 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156480

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112498

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BGE5

KEGG Orthology (KO)

More...
KOi
K10896

Database of Orthologous Groups

More...
OrthoDBi
989616at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BGE5

TreeFam database of animal gene trees

More...
TreeFami
TF324610

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006166 ERCC4_domain
IPR031879 FANCM-MHF-bd
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02732 ERCC4, 1 hit
PF16783 FANCM-MHF_bd, 1 hit
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00891 ERCC4, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781 SSF47781, 1 hit
SSF52540 SSF52540, 1 hit
SSF52980 SSF52980, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BGE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRQRTLFQ TWGPSLVRGS GDSGCGQPRS PAMAEALPEE DDEVLLVAAY
60 70 80 90 100
EAERQLDPGD GGFCAAAGAL WIYPTNCPVR DYQLDISRSA LFCNTLVCLP
110 120 130 140 150
TGLGKTFIAA VVMYNFYRWF PSGKVVFMAP TKPLVTQQME ACFHVMGIPQ
160 170 180 190 200
SHMAEMTGST QAVNRKEIWS SRRVLFLTPQ VMVNDLTRGA VPATHVKCLV
210 220 230 240 250
VDEAHKALGN YAYCQVVREL VKYTTHFRIL ALSATPGSDI KAVQQVITNL
260 270 280 290 300
LIGKIELRSE ESPDILPYSH ERRVEKLVVP LGEELGAIQK TYIQILETFA
310 320 330 340 350
SSLIHRNVLM KRDIPNLTKY QIILARDQFR KNPSPNIVGI QQGIIEGEFA
360 370 380 390 400
LCISLYHGYE LLQQMGMRSL YFFLSGIMDG TKGMTRARNE LSRNEDFMKL
410 420 430 440 450
YTHLQSAFAP ASTSDASAFQ RGNKEKKFVY SHPKLKKLEE VILEHFKSWN
460 470 480 490 500
AKATTEKKCH ESRVMIFSSF RDSVEEIAEM LLQHRPVIRV MTFVGHASGK
510 520 530 540 550
NTKGFTQKEQ LQVVRQFRDG GYNTLVSTCV GEEGLDIGEV DLIICFDAQK
560 570 580 590 600
SPIRLIQRMG RTGRKRQGRI VVILAEGREE RTYNQSQSNK KNIYKAISGN
610 620 630 640 650
RQVLRLYQGS PRMVPDKINP ELHKMYITHG VYEPEKARSV QRRPFSSRGG
660 670 680 690 700
IKASKSNKDG LLSEEEFNLW SRLYRLGDSD QVKGVALPQS HFPSLQEDRV
710 720 730 740 750
IQDPTTRIHQ LSLSEWSLWQ DRPLPTHQVD HSDRCHHFIS IMKMIEGMRH
760 770 780 790 800
EEGECSYELK IRPFLQMEDV CSKYHAPRNG YNNVASVASS AHQKSSFRPS
810 820 830 840 850
VDAGGSLTVI ESEEEHADTV KQRDSKWTKI TSLREKPCRA GRKGQTCEHS
860 870 880 890 900
EGEGEDGDAG SSDADGQSPA EADSQVDPPS GERMADVGGI SILGAVTEED
910 920 930 940 950
NHPGTLQMEC QVTNKSCARY SLDSGYSSFS DEKSVSSNLF LPLEEELFTD
960 970 980 990 1000
RAAEQFYNCR PMTEDVLANV ERFLSRSPPS LSGLSDLVYD VTQGCEFDNA
1010 1020 1030 1040 1050
SCSPYPEHEH SPRPVSPASH SAGNSQQNLE SNSAKRISHP TEKYCLPGTT
1060 1070 1080 1090 1100
HNKVSDRPSF CESDSEGHNI KYQNSGSNSC AQIQADLENN FVDKNSHDDS
1110 1120 1130 1140 1150
EPPVLFTDED ESLLLFEDDF KNIEDGPEEL NGASLPPFNS ISQPLRVSGK
1160 1170 1180 1190 1200
TLTSEMPPVS HFLISDELLL DDDSEPEDQI VCGAKSWKCQ EGVEDGQEEL
1210 1220 1230 1240 1250
RTDGQTFDCS VDLFSVTFDL GFRCSSGSDD EMLAGASDRT RTLGAADVSG
1260 1270 1280 1290 1300
RHSDKEIKDA GGASGPLGRA ISPIPTETAQ WSPWAQNKEY ASFHVASSSP
1310 1320 1330 1340 1350
VKQRVRSTPL SKSHASSKTG AHMLKTLDST KEKAGGQGFK MALNPRLGHL
1360 1370 1380 1390 1400
GFSVEETKSS DQVFVHQSPR RTEVEHLTSE SEDDVFLRKT KKPKRNVLKS
1410 1420 1430 1440 1450
PEDQKNNEVD SPIHAVKKPR VLRSELASSD DESENFGRTC PRLEHFKGRN
1460 1470 1480 1490 1500
RNIRKGSAAQ KNRSQVKTMA RRFLDDEAEV SGEDVDCVSA DEEDESENEQ
1510 1520 1530 1540 1550
DSSLLDFVND RTQLSQAIND SEMRAIYMKS VRSPLMSTKY RMVREKRPNM
1560 1570 1580 1590 1600
NIFSQIPEQD ENYLEDSFCV DEEESCKSQS SEEEISVDFN LTKDSFTDED
1610 1620 1630 1640 1650
IRYKTRYAVK IKQMNKKQNY TRPRKKLSRI ILPDDDSSEE ENIPKDREHS
1660 1670 1680 1690 1700
VAGGHAAAEH TQQGQLWASG PSGSSVPPQV LSDPSWNQSS RQRLQVQPSI
1710 1720 1730 1740 1750
TDAVPRTLNV KAQSHNKIKS ASPPCTGVES RKEYGNHPVQ LKADSQEHSD
1760 1770 1780 1790 1800
TSAAPCSTSL LHVAEGHTAP RHLQEGNRAC ILVDSREITT GLEVISSLRT
1810 1820 1830 1840 1850
VHGLQVEICP LNGCDYIVSS RMVVVRRSQS EMLSNTSKNK FIEQMQRLQS
1860 1870 1880 1890 1900
MFQRICVIVE KDREKAGDTS KKFRRTKCYD SLLTALVGAG IRILFSSGQE
1910 1920 1930 1940 1950
ETADLLKELS LVEQRKNAGI HIPAVLNTSK LEALPFYLSI PGISYITALN
1960 1970 1980 1990 2000
MCHQFSSVKK MANSSPEEIS TCAQVNHQKA EEIYKYIHYI FDMQMLPNDL
2010 2020
NQERQKPDTC LTLGVAMKEL S
Length:2,021
Mass (Da):226,018
Last modified:October 25, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8646A4535437A8AF
GO
Isoform 2 (identifier: Q8BGE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     651-651: I → E
     652-2021: Missing.

Show »
Length:651
Mass (Da):73,449
Checksum:i8D80409F6155805A
GO
Isoform 3 (identifier: Q8BGE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-433: NKEKKFVYSHP → LVFQGKLWSFT
     434-2021: Missing.

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):48,324
Checksum:iD8BE842C109AD622
GO
Isoform 4 (identifier: Q8BGE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-741: Missing.

Note: No experimental confirmation available.
Show »
Length:1,280
Mass (Da):142,131
Checksum:iE57A47289A31A783
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VKF2A0A1Y7VKF2_MOUSE
Fanconi anemia group M protein homo...
Fancm
664Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VMA3A0A1Y7VMA3_MOUSE
Fanconi anemia group M protein homo...
Fancm
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VLB8A0A1Y7VLB8_MOUSE
Fanconi anemia group M protein homo...
Fancm
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VKY9A0A1Y7VKY9_MOUSE
Fanconi anemia group M protein homo...
Fancm
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32489 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0159911 – 741Missing in isoform 4. 1 PublicationAdd BLAST741
Alternative sequenceiVSP_015992423 – 433NKEKKFVYSHP → LVFQGKLWSFT in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_015993434 – 2021Missing in isoform 3. 1 PublicationAdd BLAST1588
Alternative sequenceiVSP_015994651I → E in isoform 2. 1 Publication1
Alternative sequenceiVSP_015995652 – 2021Missing in isoform 2. 1 PublicationAdd BLAST1370

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK050306 mRNA Translation: BAC34178.2
AK053715 mRNA Translation: BAC35487.1
AK084697 mRNA Translation: BAC39257.2
AK086395 mRNA Translation: BAC39660.1
AK173211 mRNA Translation: BAD32489.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS25941.1 [Q8BGE5-1]

NCBI Reference Sequences

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RefSeqi
NP_849243.2, NM_178912.3 [Q8BGE5-1]
XP_006515407.1, XM_006515344.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000058889; ENSMUSP00000054797; ENSMUSG00000055884 [Q8BGE5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
104806

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:104806

UCSC genome browser

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UCSCi
uc007nrc.1 mouse [Q8BGE5-3]
uc007nrd.1 mouse [Q8BGE5-2]
uc007nrf.1 mouse [Q8BGE5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050306 mRNA Translation: BAC34178.2
AK053715 mRNA Translation: BAC35487.1
AK084697 mRNA Translation: BAC39257.2
AK086395 mRNA Translation: BAC39660.1
AK173211 mRNA Translation: BAD32489.1 Different initiation.
CCDSiCCDS25941.1 [Q8BGE5-1]
RefSeqiNP_849243.2, NM_178912.3 [Q8BGE5-1]
XP_006515407.1, XM_006515344.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi222708, 1 interactor
STRINGi10090.ENSMUSP00000054797

Chemistry databases

ChEMBLiCHEMBL2176806

PTM databases

iPTMnetiQ8BGE5
PhosphoSitePlusiQ8BGE5

Proteomic databases

PaxDbiQ8BGE5
PRIDEiQ8BGE5

Genome annotation databases

EnsembliENSMUST00000058889; ENSMUSP00000054797; ENSMUSG00000055884 [Q8BGE5-1]
GeneIDi104806
KEGGimmu:104806
UCSCiuc007nrc.1 mouse [Q8BGE5-3]
uc007nrd.1 mouse [Q8BGE5-2]
uc007nrf.1 mouse [Q8BGE5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57697
MGIiMGI:2442306 Fancm

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG0354 Eukaryota
KOG0442 Eukaryota
COG1111 LUCA
GeneTreeiENSGT00940000156480
HOGENOMiHOG000112498
InParanoidiQ8BGE5
KOiK10896
OrthoDBi989616at2759
PhylomeDBiQ8BGE5
TreeFamiTF324610

Enzyme and pathway databases

ReactomeiR-MMU-6783310 Fanconi Anemia Pathway

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8BGE5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000055884 Expressed in 162 organ(s), highest expression level in embryo
ExpressionAtlasiQ8BGE5 baseline and differential
GenevisibleiQ8BGE5 MM

Family and domain databases

InterProiView protein in InterPro
IPR006166 ERCC4_domain
IPR031879 FANCM-MHF-bd
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like
PfamiView protein in Pfam
PF02732 ERCC4, 1 hit
PF16783 FANCM-MHF_bd, 1 hit
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00891 ERCC4, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF52540 SSF52540, 1 hit
SSF52980 SSF52980, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFANCM_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BGE5
Secondary accession number(s): Q69ZF5, Q8BKB7, Q8BUA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: October 16, 2019
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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