Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 4B

Gene

Eif4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-166208 mTORC1-mediated signalling
R-MMU-429947 Deadenylation of mRNA
R-MMU-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4B
Short name:
eIF-4B
Gene namesi
Name:Eif4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:95304 Eif4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816171 – 611Eukaryotic translation initiation factor 4BAdd BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineCombined sources1
Modified residuei192PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Cross-linki343Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei359PhosphoserineBy similarity1
Modified residuei365N6-acetyllysineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineBy similarity1
Modified residuei412PhosphothreonineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei422PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei445PhosphoserineBy similarity1
Modified residuei459PhosphoserineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei497PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei500PhosphothreonineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei506PhosphothreonineCombined sources1
Modified residuei586N6-acetyllysineBy similarity1
Modified residuei597PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BGD9
MaxQBiQ8BGD9
PaxDbiQ8BGD9
PRIDEiQ8BGD9

PTM databases

iPTMnetiQ8BGD9
PhosphoSitePlusiQ8BGD9
SwissPalmiQ8BGD9

Expressioni

Gene expression databases

BgeeiENSMUSG00000058655 Expressed in 307 organ(s), highest expression level in heart
CleanExiMM_EIF4B
ExpressionAtlasiQ8BGD9 baseline and differential
GenevisibleiQ8BGD9 MM

Interactioni

Subunit structurei

Self-associates and interacts with EIF3 p170 subunit.By similarity

Protein-protein interaction databases

BioGridi217684, 4 interactors
IntActiQ8BGD9, 2 interactors
MINTiQ8BGD9
STRINGi10090.ENSMUSP00000127774

Structurei

3D structure databases

ProteinModelPortaliQ8BGD9
SMRiQ8BGD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 173RRMPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi164 – 440Arg-richAdd BLAST277
Compositional biasi169 – 325Asp-richAdd BLAST157

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
ENOG4111NS2 LUCA
GeneTreeiENSGT00530000063406
HOGENOMiHOG000006553
HOVERGENiHBG006129
InParanoidiQ8BGD9
KOiK03258
OMAiWTRKGPL
OrthoDBiEOG091G0DWC
PhylomeDBiQ8BGD9
TreeFamiTF101525

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR033107 EIF-4B
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR23236:SF2 PTHR23236:SF2, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BGD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVPKPVSW ADETDDLEGD
60 70 80 90 100
VSTTWHSNDD DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL
110 120 130 140 150
GNLPYDVTED SIKDFFRGLN ISAVRLPREP SNPDRLKGFG YAEFEDLDSL
160 170 180 190 200
LSALSLNEES LGNRRIRVDV ADQAQDKDRD DRSFGRDRNR DSDKTDTDWR
210 220 230 240 250
ARPTTDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG YRDGPRRDMD
260 270 280 290 300
RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED
310 320 330 340 350
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPRLNLKPRS APKEDDASAS
360 370 380 390 400
TSQSSRAASI FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLDRRP
410 420 430 440 450
RERHPSWRSE ETQERERSRT GSESSQTGAS ATSGRNTRRR ESEKSLENET
460 470 480 490 500
LNKEEDCHSP TSKPPKPDQP LKVMPAPPPK ENAWVKRSSN PPARSQSSDT
510 520 530 540 550
EQPSPTSGGG KVAAVQPPEE GPSRKDGNKV DVVGATQGQA GSCSRGPGDG
560 570 580 590 600
GSRDHWKDLD RKDGKKDQDS RSAPEPKKPE ENPASKFSSA SKYAALSVDG
610
EDEDEGDDCT E
Length:611
Mass (Da):68,840
Last modified:March 1, 2003 - v1
Checksum:iA3254EBF55EDB6F2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RWE8B2RWE8_MOUSE
Eif4b protein
Eif4b
403Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045250 mRNA Translation: BAC32280.1
AK077423 mRNA Translation: BAC36793.1
AK170354 mRNA Translation: BAE41740.1
CCDSiCCDS49737.1
RefSeqiNP_663600.2, NM_145625.3
UniGeneiMm.290022
Mm.391795
Mm.415249

Genome annotation databases

EnsembliENSMUST00000169681; ENSMUSP00000127774; ENSMUSG00000058655
GeneIDi75705
KEGGimmu:75705
UCSCiuc007xuk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045250 mRNA Translation: BAC32280.1
AK077423 mRNA Translation: BAC36793.1
AK170354 mRNA Translation: BAE41740.1
CCDSiCCDS49737.1
RefSeqiNP_663600.2, NM_145625.3
UniGeneiMm.290022
Mm.391795
Mm.415249

3D structure databases

ProteinModelPortaliQ8BGD9
SMRiQ8BGD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217684, 4 interactors
IntActiQ8BGD9, 2 interactors
MINTiQ8BGD9
STRINGi10090.ENSMUSP00000127774

PTM databases

iPTMnetiQ8BGD9
PhosphoSitePlusiQ8BGD9
SwissPalmiQ8BGD9

Proteomic databases

EPDiQ8BGD9
MaxQBiQ8BGD9
PaxDbiQ8BGD9
PRIDEiQ8BGD9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169681; ENSMUSP00000127774; ENSMUSG00000058655
GeneIDi75705
KEGGimmu:75705
UCSCiuc007xuk.2 mouse

Organism-specific databases

CTDi1975
MGIiMGI:95304 Eif4b

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
ENOG4111NS2 LUCA
GeneTreeiENSGT00530000063406
HOGENOMiHOG000006553
HOVERGENiHBG006129
InParanoidiQ8BGD9
KOiK03258
OMAiWTRKGPL
OrthoDBiEOG091G0DWC
PhylomeDBiQ8BGD9
TreeFamiTF101525

Enzyme and pathway databases

ReactomeiR-MMU-166208 mTORC1-mediated signalling
R-MMU-429947 Deadenylation of mRNA
R-MMU-72702 Ribosomal scanning and start codon recognition

Miscellaneous databases

ChiTaRSiEif4b mouse
PROiPR:Q8BGD9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058655 Expressed in 307 organ(s), highest expression level in heart
CleanExiMM_EIF4B
ExpressionAtlasiQ8BGD9 baseline and differential
GenevisibleiQ8BGD9 MM

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR033107 EIF-4B
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR23236:SF2 PTHR23236:SF2, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIF4B_MOUSE
AccessioniPrimary (citable) accession number: Q8BGD9
Secondary accession number(s): Q3TD64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again