Eif4b

Functionⁱ

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F (By similarity).By similarity

GO - Molecular functionⁱ

ribosomal small subunit binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA strand annealing activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA strand-exchange activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
translation initiation factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoplasmic translation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
eukaryotic translation initiation factor 4F complex assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
formation of translation preinitiation complex
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factor, RNA-binding
Biological process	Protein biosynthesis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-166208 mTORC1-mediated signalling R-MMU-429947 Deadenylation of mRNA R-MMU-72702 Ribosomal scanning and start codon recognition

Reactomeⁱ

R-MMU-166208 mTORC1-mediated signalling
R-MMU-429947 Deadenylation of mRNA
R-MMU-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 4B Short name: eIF-4B
Gene namesⁱ	Name:Eif4b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:95304 Eif4b

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081617	1 – 611	Eukaryotic translation initiation factor 4BAdd BLAST		611

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	93	PhosphoserineCombined sources	1
Modified residueⁱ	192	PhosphoserineBy similarity	1
Modified residueⁱ	207	PhosphoserineBy similarity	1
Modified residueⁱ	219	PhosphoserineBy similarity	1
Modified residueⁱ	283	PhosphoserineBy similarity	1
Cross-linkⁱ	343	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	359	PhosphoserineBy similarity	1
Modified residueⁱ	365	N6-acetyllysineCombined sources	1
Modified residueⁱ	406	PhosphoserineCombined sources	1
Modified residueⁱ	409	PhosphoserineBy similarity	1
Modified residueⁱ	412	PhosphothreonineBy similarity	1
Modified residueⁱ	418	PhosphoserineBy similarity	1
Modified residueⁱ	422	PhosphoserineCombined sources	1
Modified residueⁱ	425	PhosphoserineCombined sources	1
Modified residueⁱ	445	PhosphoserineBy similarity	1
Modified residueⁱ	459	PhosphoserineBy similarity	1
Modified residueⁱ	462	PhosphoserineBy similarity	1
Modified residueⁱ	497	PhosphoserineCombined sources	1
Modified residueⁱ	498	PhosphoserineCombined sources	1
Modified residueⁱ	500	PhosphothreonineCombined sources	1
Modified residueⁱ	504	PhosphoserineCombined sources	1
Modified residueⁱ	506	PhosphothreonineCombined sources	1
Modified residueⁱ	586	N6-acetyllysineBy similarity	1
Modified residueⁱ	597	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8BGD9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BGD9
PaxDbⁱ	Q8BGD9
PRIDEⁱ	Q8BGD9

PTM databases

iPTMnetⁱ	Q8BGD9
PhosphoSitePlusⁱ	Q8BGD9
SwissPalmⁱ	Q8BGD9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000058655 Expressed in 307 organ(s), highest expression level in heart
CleanExⁱ	MM_EIF4B
ExpressionAtlasⁱ	Q8BGD9 baseline and differential
Genevisibleⁱ	Q8BGD9 MM

Interactionⁱ

Subunit structureⁱ

Self-associates and interacts with EIF3 p170 subunit.By similarity

Protein-protein interaction databases

BioGridⁱ	217684, 4 interactors
IntActⁱ	Q8BGD9, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q8BGD9
STRINGⁱ	10090.ENSMUSP00000127774

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BGD9
SMRⁱ	Q8BGD9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	96 – 173	RRMPROSITE-ProRule annotationAdd BLAST		78

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	164 – 440	Arg-richAdd BLAST		277
Compositional biasⁱ	169 – 325	Asp-richAdd BLAST		157

Phylogenomic databases

eggNOGⁱ	KOG0118 Eukaryota ENOG4111NS2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063406
HOGENOMⁱ	HOG000006553
HOVERGENⁱ	HBG006129
InParanoidⁱ	Q8BGD9
KEGG Orthology (KO) More...KOⁱ	K03258
OMAⁱ	WTRKGPL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DWC
PhylomeDBⁱ	Q8BGD9
TreeFamⁱ	TF101525

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR033107 EIF-4B IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR23236:SF2 PTHR23236:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8BGD9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVPKPVSW ADETDDLEGD 
        60         70         80         90        100
VSTTWHSNDD DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL 
       110        120        130        140        150
GNLPYDVTED SIKDFFRGLN ISAVRLPREP SNPDRLKGFG YAEFEDLDSL 
       160        170        180        190        200
LSALSLNEES LGNRRIRVDV ADQAQDKDRD DRSFGRDRNR DSDKTDTDWR 
       210        220        230        240        250
ARPTTDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG YRDGPRRDMD 
       260        270        280        290        300
RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 
       310        320        330        340        350
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPRLNLKPRS APKEDDASAS 
       360        370        380        390        400
TSQSSRAASI FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLDRRP 
       410        420        430        440        450
RERHPSWRSE ETQERERSRT GSESSQTGAS ATSGRNTRRR ESEKSLENET 
       460        470        480        490        500
LNKEEDCHSP TSKPPKPDQP LKVMPAPPPK ENAWVKRSSN PPARSQSSDT 
       510        520        530        540        550
EQPSPTSGGG KVAAVQPPEE GPSRKDGNKV DVVGATQGQA GSCSRGPGDG 
       560        570        580        590        600
GSRDHWKDLD RKDGKKDQDS RSAPEPKKPE ENPASKFSSA SKYAALSVDG 
       610 
EDEDEGDDCT E

Length:611

Mass (Da):68,840

Last modified:March 1, 2003 - v1

Checksum:ⁱA3254EBF55EDB6F2

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B2RWE8	B2RWE8_MOUSE		Eif4b protein Eif4b protein (Eukaryotic translation initiation factor 4B)	Eif4b	403	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK045250 mRNA Translation: BAC32280.1 AK077423 mRNA Translation: BAC36793.1 AK170354 mRNA Translation: BAE41740.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS49737.1
NCBI Reference Sequences More...RefSeqⁱ	NP_663600.2, NM_145625.3
UniGeneⁱ	Mm.290022 Mm.391795 Mm.415249

Genome annotation databases

Ensemblⁱ	ENSMUST00000169681; ENSMUSP00000127774; ENSMUSG00000058655
GeneIDⁱ	75705
KEGGⁱ	mmu:75705
UCSC genome browser More...UCSCⁱ	uc007xuk.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q8BGD9	Eukaryotic translation initiation factor 4B		MOUSE		363	UniRef100_Q8BGD9
Eukaryotic translation initiation factor 4B-like protein (Fragment)		Daphnia magna		127
Eif4b protein		MOUSE		403

Protein	Similar proteins		Species	Score	Length	Source
Q8BGD9	Eukaryotic translation initiation factor 4B	)	HUMAN		611	UniRef90_P23588
Eukaryotic translation initiation factor 4B		MYOBR		646
Eukaryotic translation initiation factor 4B		MYODS		633
eukaryotic translation initiation factor 4B isoform X1		PHYCD		629
Eukaryotic translation initiation factor 4B		CASCN		619
+292

Protein	Similar proteins		Species	Score	Length	Source
Q8BGD9	Eukaryotic translation initiation factor 4B	)	HUMAN		611	UniRef50_P23588
Eukaryotic translation initiation factor 4B		MYOBR		646
Eukaryotic translation initiation factor 4B		MYODS		633
eukaryotic translation initiation factor 4B isoform X1		PHYCD		629
Eukaryotic translation initiation factor 4B		CASCN		619
+544

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK045250 mRNA Translation: BAC32280.1 AK077423 mRNA Translation: BAC36793.1 AK170354 mRNA Translation: BAE41740.1
CCDSⁱ	CCDS49737.1
RefSeqⁱ	NP_663600.2, NM_145625.3
UniGeneⁱ	Mm.290022 Mm.391795 Mm.415249

3D structure databases

ProteinModelPortalⁱ	Q8BGD9
SMRⁱ	Q8BGD9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	217684, 4 interactors
IntActⁱ	Q8BGD9, 2 interactors
MINTⁱ	Q8BGD9
STRINGⁱ	10090.ENSMUSP00000127774

PTM databases

iPTMnetⁱ	Q8BGD9
PhosphoSitePlusⁱ	Q8BGD9
SwissPalmⁱ	Q8BGD9

Proteomic databases

EPDⁱ	Q8BGD9
MaxQBⁱ	Q8BGD9
PaxDbⁱ	Q8BGD9
PRIDEⁱ	Q8BGD9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000169681; ENSMUSP00000127774; ENSMUSG00000058655
GeneIDⁱ	75705
KEGGⁱ	mmu:75705
UCSCⁱ	uc007xuk.2 mouse

Organism-specific databases

CTDⁱ	1975
MGIⁱ	MGI:95304 Eif4b

Phylogenomic databases

eggNOGⁱ	KOG0118 Eukaryota ENOG4111NS2 LUCA
GeneTreeⁱ	ENSGT00530000063406
HOGENOMⁱ	HOG000006553
HOVERGENⁱ	HBG006129
InParanoidⁱ	Q8BGD9
KOⁱ	K03258
OMAⁱ	WTRKGPL
OrthoDBⁱ	EOG091G0DWC
PhylomeDBⁱ	Q8BGD9
TreeFamⁱ	TF101525

Enzyme and pathway databases

Reactomeⁱ	R-MMU-166208 mTORC1-mediated signalling R-MMU-429947 Deadenylation of mRNA R-MMU-72702 Ribosomal scanning and start codon recognition

Reactomeⁱ

R-MMU-166208 mTORC1-mediated signalling
R-MMU-429947 Deadenylation of mRNA
R-MMU-72702 Ribosomal scanning and start codon recognition

Miscellaneous databases

ChiTaRSⁱ	Eif4b mouse
Protein Ontology More...PROⁱ	PR:Q8BGD9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000058655 Expressed in 307 organ(s), highest expression level in heart
CleanExⁱ	MM_EIF4B
ExpressionAtlasⁱ	Q8BGD9 baseline and differential
Genevisibleⁱ	Q8BGD9 MM

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR033107 EIF-4B IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR23236:SF2 PTHR23236:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IF4B_MOUSE
Accessionⁱ	Q8BGD9Primary (citable) accession number: Q8BGD9 Secondary accession number(s): Q3TD64
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Translation initiation factors
List of translation initiation factor entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BGD9 (IF4B_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Eukaryotic translation initiation factor 4B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ