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Protein

UPF0489 protein C5orf22 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0489 protein C5orf22 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1925127 6030458C11Rik

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003050031 – 442UPF0489 protein C5orf22 homologAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphothreonineCombined sources1
Modified residuei285PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8BGC1

PeptideAtlas

More...
PeptideAtlasi
Q8BGC1

PRoteomics IDEntifications database

More...
PRIDEi
Q8BGC1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BGC1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BGC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022195 Expressed in 261 organ(s), highest expression level in primary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
MM_6030458C11RIK

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BGC1 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0489 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGS7 Eukaryota
ENOG41109E9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001801

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000008429

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057060

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BGC1

Identification of Orthologs from Complete Genome Data

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OMAi
LDVIMVK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0TRE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BGC1

TreeFam database of animal gene trees

More...
TreeFami
TF324160

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024131 UPF0489

The PANTHER Classification System

More...
PANTHERi
PTHR13225 PTHR13225, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12640 UPF0489, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BGC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDTGGDRAR LRRYTKLPVW VVEDHQEVLP FIYRAIGSKH LPDSNISFLH
60 70 80 90 100
LDSHPDLLIP VNMPADTVFD KEALFGELSI ENWIMPAVYA GHFSQVIWLH
110 120 130 140 150
PTWAQQIREG KHCFLVGKDI STTTIRVTST DSYFLSDGLF VPEDQLENRR
160 170 180 190 200
PLQLDVILVE PYTLCSKQDD SDSVSSTKKP KLALGSGESS AAADGHSCSE
210 220 230 240 250
GRRGDAVTPR SDHACQEPSC SRSGGQQSQN TATAGAILDI LKTGDAFVLD
260 270 280 290 300
IDLDFFSVKN PFKEMFTQDE YKILQELYQF KKPDSNLPED GLVDVVEART
310 320 330 340 350
HQLEDLEAVF ADLCDGDSEE TVQSWASNPG MESLVPLVQS LKKRMEVPDY
360 370 380 390 400
EMVHQAGLTC DYSELPHHIS TEEEIEYLIQ SVYFLLKSLP KPTLVTIARS
410 420 430 440
SLDDYCPPEQ VDMIQGKVLD VLHSLYGTLD THLVYSEESP LS
Length:442
Mass (Da):49,430
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABB258105F715951
GO
Isoform 2 (identifier: Q8BGC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-178: VLPFIYRAIG...DDSDSVSSTK → RTEYRKLDYA...RQRHFYHNHQ

Show »
Length:341
Mass (Da):38,208
Checksum:iE6A1AC97169FDEE7
GO
Isoform 3 (identifier: Q8BGC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-442: Missing.

Show »
Length:126
Mass (Da):14,452
Checksum:iEC66E667704AFEAB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRJ4A0A2I3BRJ4_MOUSE
RIKEN cDNA 6030458C11 gene
6030458C11Rik
358Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12R → K in BAC29550 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02818528 – 178VLPFI…VSSTK → RTEYRKLDYACSLRWPFFSS NLAPPHVGPANQGGQALLLS RQRHFYHNHQ in isoform 2. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_028186127 – 442Missing in isoform 3. 2 PublicationsAdd BLAST316

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK020074 mRNA Translation: BAB31984.1
AK035859 mRNA Translation: BAC29215.1
AK036721 mRNA Translation: BAC29550.2
AK037867 mRNA Translation: BAC29887.1
AK038561 mRNA Translation: BAC30044.1
AK054133 mRNA Translation: BAC35665.1
AK081625 mRNA Translation: BAC38275.1
BC119058 mRNA Translation: AAI19059.1
BC028769 mRNA Translation: AAH28769.1
BC099607 mRNA Translation: AAH99607.1
BC137759 mRNA Translation: AAI37760.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS27392.1 [Q8BGC1-1]

NCBI Reference Sequences

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RefSeqi
NP_001159832.1, NM_001166360.1 [Q8BGC1-3]
NP_084274.1, NM_029998.3 [Q8BGC1-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.207311

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000057256; ENSMUSP00000055656; ENSMUSG00000022195 [Q8BGC1-1]
ENSMUST00000228177; ENSMUSP00000154147; ENSMUSG00000022195 [Q8BGC1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
77877

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:77877

UCSC genome browser

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UCSCi
uc007vhw.2 mouse [Q8BGC1-1]
uc007vhx.2 mouse [Q8BGC1-2]
uc007vhz.2 mouse [Q8BGC1-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020074 mRNA Translation: BAB31984.1
AK035859 mRNA Translation: BAC29215.1
AK036721 mRNA Translation: BAC29550.2
AK037867 mRNA Translation: BAC29887.1
AK038561 mRNA Translation: BAC30044.1
AK054133 mRNA Translation: BAC35665.1
AK081625 mRNA Translation: BAC38275.1
BC119058 mRNA Translation: AAI19059.1
BC028769 mRNA Translation: AAH28769.1
BC099607 mRNA Translation: AAH99607.1
BC137759 mRNA Translation: AAI37760.1
CCDSiCCDS27392.1 [Q8BGC1-1]
RefSeqiNP_001159832.1, NM_001166360.1 [Q8BGC1-3]
NP_084274.1, NM_029998.3 [Q8BGC1-1]
UniGeneiMm.207311

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

PTM databases

iPTMnetiQ8BGC1
PhosphoSitePlusiQ8BGC1

Proteomic databases

PaxDbiQ8BGC1
PeptideAtlasiQ8BGC1
PRIDEiQ8BGC1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057256; ENSMUSP00000055656; ENSMUSG00000022195 [Q8BGC1-1]
ENSMUST00000228177; ENSMUSP00000154147; ENSMUSG00000022195 [Q8BGC1-2]
GeneIDi77877
KEGGimmu:77877
UCSCiuc007vhw.2 mouse [Q8BGC1-1]
uc007vhx.2 mouse [Q8BGC1-2]
uc007vhz.2 mouse [Q8BGC1-3]

Organism-specific databases

MGIiMGI:1925127 6030458C11Rik

Phylogenomic databases

eggNOGiENOG410IGS7 Eukaryota
ENOG41109E9 LUCA
GeneTreeiENSGT00390000001801
HOGENOMiHOG000008429
HOVERGENiHBG057060
InParanoidiQ8BGC1
OMAiLDVIMVK
OrthoDBiEOG091G0TRE
PhylomeDBiQ8BGC1
TreeFamiTF324160

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8BGC1

Gene expression databases

BgeeiENSMUSG00000022195 Expressed in 261 organ(s), highest expression level in primary oocyte
CleanExiMM_6030458C11RIK
GenevisibleiQ8BGC1 MM

Family and domain databases

InterProiView protein in InterPro
IPR024131 UPF0489
PANTHERiPTHR13225 PTHR13225, 1 hit
PfamiView protein in Pfam
PF12640 UPF0489, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE022_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BGC1
Secondary accession number(s): B2RQ49
, Q8BYV3, Q8BZ46, Q9CX64
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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