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Protein

Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

Gene

Coq4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Biological processi

Keywordsi

Biological processUbiquinone biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialUniRule annotation
Alternative name(s):
Coenzyme Q biosynthesis protein 4 homologUniRule annotation
Gene namesi
Name:Coq4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1098826 Coq4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionUniRule annotationAdd BLAST30
ChainiPRO_000032029131 – 266Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BGB8
MaxQBiQ8BGB8
PaxDbiQ8BGB8
PRIDEiQ8BGB8

PTM databases

iPTMnetiQ8BGB8
PhosphoSitePlusiQ8BGB8
SwissPalmiQ8BGB8

Expressioni

Gene expression databases

BgeeiENSMUSG00000026798 Expressed in 274 organ(s), highest expression level in brown adipose tissue
CleanExiMM_COQ4
ExpressionAtlasiQ8BGB8 baseline and differential
GenevisibleiQ8BGB8 MM

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

BioGridi230662, 1 interactor
ComplexPortaliCPX-3662 CoQ biosynthetic complex
STRINGi10090.ENSMUSP00000028137

Structurei

3D structure databases

ProteinModelPortaliQ8BGB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ4 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3244 Eukaryota
COG5031 LUCA
GeneTreeiENSGT00390000003828
HOGENOMiHOG000194110
HOVERGENiHBG027006
InParanoidiQ8BGB8
KOiK18586
OMAiVTPDTRE
OrthoDBiEOG091G0KCU
PhylomeDBiQ8BGB8
TreeFamiTF314625

Family and domain databases

HAMAPiMF_03111 Coq4, 1 hit
InterProiView protein in InterPro
IPR007715 Coq4
IPR027540 Coq4_euk
PANTHERiPTHR12922 PTHR12922, 1 hit
PTHR12922:SF7 PTHR12922:SF7, 1 hit
PfamiView protein in Pfam
PF05019 Coq4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8BGB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLLLLRSL RLHRSLRPRT RPAVDVPLRA GSHGARLLYP DHIPTTPLQK
60 70 80 90 100
MLLAAGAAGM ALYNPYRHDM VAVLGETTGC HTLKFLRDQM KKDPEGAQIL
110 120 130 140 150
QERPRISLST LDLSKLQSLP EGSLGREYLR FLDVNKVSPD TRAPTRFVDD
160 170 180 190 200
EELAYVIQRY REVHDMLHTL LGMPTNMLGE VVVKWFEAVQ TGLPMCILGA
210 220 230 240 250
LFGPIRLRTQ SLQVLFSELI PWAIQNGRRA PCVLNIYYEQ RWEQPLTALR
260
EELGISPPPK HIQGLA
Length:266
Mass (Da):30,084
Last modified:March 1, 2003 - v1
Checksum:iAD4CB7CAD1690A73
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZCV4B7ZCV4_MOUSE
Ubiquinone biosynthesis protein COQ...
Coq4
199Annotation score:
D6RJJ8D6RJJ8_MOUSE
Ubiquinone biosynthesis protein COQ...
Coq4
140Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039422 mRNA Translation: BAC30344.1
AK039676 mRNA Translation: BAC30416.1
AK050459 mRNA Translation: BAC34269.1
AL845323 Genomic DNA No translation available.
CCDSiCCDS15857.1
RefSeqiNP_848808.1, NM_178693.5
UniGeneiMm.245948

Genome annotation databases

EnsembliENSMUST00000028137; ENSMUSP00000028137; ENSMUSG00000026798
GeneIDi227683
KEGGimmu:227683
UCSCiuc008jac.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039422 mRNA Translation: BAC30344.1
AK039676 mRNA Translation: BAC30416.1
AK050459 mRNA Translation: BAC34269.1
AL845323 Genomic DNA No translation available.
CCDSiCCDS15857.1
RefSeqiNP_848808.1, NM_178693.5
UniGeneiMm.245948

3D structure databases

ProteinModelPortaliQ8BGB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230662, 1 interactor
ComplexPortaliCPX-3662 CoQ biosynthetic complex
STRINGi10090.ENSMUSP00000028137

PTM databases

iPTMnetiQ8BGB8
PhosphoSitePlusiQ8BGB8
SwissPalmiQ8BGB8

Proteomic databases

EPDiQ8BGB8
MaxQBiQ8BGB8
PaxDbiQ8BGB8
PRIDEiQ8BGB8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028137; ENSMUSP00000028137; ENSMUSG00000026798
GeneIDi227683
KEGGimmu:227683
UCSCiuc008jac.1 mouse

Organism-specific databases

CTDi51117
MGIiMGI:1098826 Coq4

Phylogenomic databases

eggNOGiKOG3244 Eukaryota
COG5031 LUCA
GeneTreeiENSGT00390000003828
HOGENOMiHOG000194110
HOVERGENiHBG027006
InParanoidiQ8BGB8
KOiK18586
OMAiVTPDTRE
OrthoDBiEOG091G0KCU
PhylomeDBiQ8BGB8
TreeFamiTF314625

Enzyme and pathway databases

UniPathwayi
UPA00232

Miscellaneous databases

ChiTaRSiCoq4 mouse
PROiPR:Q8BGB8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026798 Expressed in 274 organ(s), highest expression level in brown adipose tissue
CleanExiMM_COQ4
ExpressionAtlasiQ8BGB8 baseline and differential
GenevisibleiQ8BGB8 MM

Family and domain databases

HAMAPiMF_03111 Coq4, 1 hit
InterProiView protein in InterPro
IPR007715 Coq4
IPR027540 Coq4_euk
PANTHERiPTHR12922 PTHR12922, 1 hit
PTHR12922:SF7 PTHR12922:SF7, 1 hit
PfamiView protein in Pfam
PF05019 Coq4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOQ4_MOUSE
AccessioniPrimary (citable) accession number: Q8BGB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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