Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM domain-containing protein 2

Gene

Limd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an activator of the protein-kinase ILK, thereby regulating cell motility.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Zinc 1By similarity1
Metal bindingi44Zinc 1By similarity1
Metal bindingi62Zinc 1; via pros nitrogenBy similarity1
Metal bindingi65Zinc 1By similarity1
Metal bindingi68Zinc 2By similarity1
Metal bindingi71Zinc 2By similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2; via pros nitrogenBy similarity1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain-containing protein 2Curated
Gene namesi
Name:Limd2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915053 Limd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512081 – 128LIM domain-containing protein 2Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BGB5
MaxQBiQ8BGB5
PaxDbiQ8BGB5
PeptideAtlasiQ8BGB5
PRIDEiQ8BGB5

PTM databases

iPTMnetiQ8BGB5
PhosphoSitePlusiQ8BGB5

Expressioni

Gene expression databases

BgeeiENSMUSG00000040699 Expressed in 291 organ(s), highest expression level in peripheral lymph node
CleanExiMM_LIMD2
GenevisibleiQ8BGB5 MM

Interactioni

Subunit structurei

Interacts with ILK.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045357

Structurei

3D structure databases

ProteinModelPortaliQ8BGB5
SMRiQ8BGB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 99LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiENOG410ITI3 Eukaryota
ENOG4111S7F LUCA
GeneTreeiENSGT00510000046839
HOGENOMiHOG000111235
HOVERGENiHBG056520
InParanoidiQ8BGB5
OMAiQATPSHE
OrthoDBiEOG091G0043
PhylomeDBiQ8BGB5

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BGB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQAAGAAQA TPSHEAKGSS GSSTVQRSKS FSLRAQVKET CAACQKTVYP
60 70 80 90 100
MERLVADKLI FHNSCFCCKH CHTKLSLGSY AAMHGEFYCR PHFQQLFKSK
110 120
GNYDEGFGRK QHKELWAHKE VDSGTKTA
Length:128
Mass (Da):14,237
Last modified:March 1, 2003 - v1
Checksum:iADF9161771331D13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012581 mRNA Translation: BAC25371.1
AK032430 mRNA Translation: BAC27866.1
AK049809 mRNA Translation: BAC33928.1
AK167349 mRNA Translation: BAE39448.1
AK169829 mRNA Translation: BAE41396.1
AK171794 mRNA Translation: BAE42667.1
BC068130 mRNA Translation: AAH68130.1
CCDSiCCDS25549.1
RefSeqiNP_765985.1, NM_172397.3
XP_006534082.1, XM_006534019.3
XP_006534083.1, XM_006534020.3
UniGeneiMm.21687

Genome annotation databases

EnsembliENSMUST00000045923; ENSMUSP00000045357; ENSMUSG00000040699
ENSMUST00000064545; ENSMUSP00000067070; ENSMUSG00000040699
ENSMUST00000106875; ENSMUSP00000102488; ENSMUSG00000040699
GeneIDi67803
KEGGimmu:67803
UCSCiuc007lyd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012581 mRNA Translation: BAC25371.1
AK032430 mRNA Translation: BAC27866.1
AK049809 mRNA Translation: BAC33928.1
AK167349 mRNA Translation: BAE39448.1
AK169829 mRNA Translation: BAE41396.1
AK171794 mRNA Translation: BAE42667.1
BC068130 mRNA Translation: AAH68130.1
CCDSiCCDS25549.1
RefSeqiNP_765985.1, NM_172397.3
XP_006534082.1, XM_006534019.3
XP_006534083.1, XM_006534020.3
UniGeneiMm.21687

3D structure databases

ProteinModelPortaliQ8BGB5
SMRiQ8BGB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045357

PTM databases

iPTMnetiQ8BGB5
PhosphoSitePlusiQ8BGB5

Proteomic databases

EPDiQ8BGB5
MaxQBiQ8BGB5
PaxDbiQ8BGB5
PeptideAtlasiQ8BGB5
PRIDEiQ8BGB5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045923; ENSMUSP00000045357; ENSMUSG00000040699
ENSMUST00000064545; ENSMUSP00000067070; ENSMUSG00000040699
ENSMUST00000106875; ENSMUSP00000102488; ENSMUSG00000040699
GeneIDi67803
KEGGimmu:67803
UCSCiuc007lyd.1 mouse

Organism-specific databases

CTDi80774
MGIiMGI:1915053 Limd2

Phylogenomic databases

eggNOGiENOG410ITI3 Eukaryota
ENOG4111S7F LUCA
GeneTreeiENSGT00510000046839
HOGENOMiHOG000111235
HOVERGENiHBG056520
InParanoidiQ8BGB5
OMAiQATPSHE
OrthoDBiEOG091G0043
PhylomeDBiQ8BGB5

Miscellaneous databases

PROiPR:Q8BGB5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040699 Expressed in 291 organ(s), highest expression level in peripheral lymph node
CleanExiMM_LIMD2
GenevisibleiQ8BGB5 MM

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIMD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again