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Protein

Tetratricopeptide repeat protein 7A

Gene

Ttc7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis (By similarity). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity).By similarity

GO - Biological processi

  • cellular iron ion homeostasis Source: MGI
  • hemopoiesis Source: MGI
  • protein localization to plasma membrane Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 7A
Short name:
TPR repeat protein 7A
Gene namesi
Name:Ttc7a
Synonyms:Ttc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1920999 Ttc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063861 – 858Tetratricopeptide repeat protein 7AAdd BLAST858

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei648PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei679PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei693PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BGB2
MaxQBiQ8BGB2
PaxDbiQ8BGB2
PeptideAtlasiQ8BGB2
PRIDEiQ8BGB2

PTM databases

iPTMnetiQ8BGB2
PhosphoSitePlusiQ8BGB2

Expressioni

Gene expression databases

BgeeiENSMUSG00000036918
CleanExiMM_TTC7
ExpressionAtlasiQ8BGB2 baseline and differential
GenevisibleiQ8BGB2 MM

Interactioni

Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (By similarity). Interacts with PI4KA, interaction is direct (By similarity). Interacts with EFR3 (EFR3A or EFR3B), interaction is direct (By similarity). Interacts with FAM126 (FAM126A or FAM126B), interaction is direct (By similarity). Association with the PI4K complex is strongly reduced by TMEM150A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040771

Structurei

3D structure databases

ProteinModelPortaliQ8BGB2
SMRiQ8BGB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati122 – 158TPR 1Add BLAST37
Repeati415 – 448TPR 2Add BLAST34
Repeati498 – 532TPR 3Add BLAST35
Repeati533 – 566TPR 4Add BLAST34
Repeati567 – 600TPR 5Add BLAST34
Repeati745 – 778TPR 6Add BLAST34
Repeati779 – 812TPR 7Add BLAST34
Repeati813 – 846TPR 8Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4162 Eukaryota
ENOG410XQ09 LUCA
GeneTreeiENSGT00390000014400
HOGENOMiHOG000045494
HOVERGENiHBG059763
InParanoidiQ8BGB2
KOiK21843
OMAiGDNLYCP
OrthoDBiEOG091G07XU
PhylomeDBiQ8BGB2
TreeFamiTF313783

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR026900 Ttc7A
PANTHERiPTHR23083:SF475 PTHR23083:SF475, 1 hit
PfamiView protein in Pfam
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 8 hits
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 3 hits

Sequencei

Sequence statusi: Complete.

Q8BGB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKGAHGTH LKVESEVERC RAEGQWDRMF ELARHLQMLG ISGGGSSNRR
60 70 80 90 100
NSPSGRFTTL DTDDFVKLLL AEALLEQCLK DNHDKIKNSI PLLEKTDHRL
110 120 130 140 150
NEAKDHLSSL LNNGKLPPQY MCEAMLILGK LHYVEGSYRD AVSMYARAGI
160 170 180 190 200
DDISVENKPL YQMRLLSEAF VIKGLSLERL PNSVASHIRL TEREEEVVAC
210 220 230 240 250
FERASWVAQV FLQELEKTSN NSTSRHLKGS LSPDYELSYF LEAALQSAYV
260 270 280 290 300
KNLKKGNIVK GMRELREILR TVETKATQNF KVVAAKHLAG VLLHSLSEDC
310 320 330 340 350
YWSPLSHPLP EFMNKEENSF VTQTLRKPHL YEGDNLYCPK DNIEEALLLL
360 370 380 390 400
LISESMATRD VVLSRAPEQA EDRKVSLQNA SAIYDLLSIT LGRRGQYVML
410 420 430 440 450
SECLERAMKC AFGEFHLWYQ VALSMVACGK SAYAVSLLRE CMKLQPSDPT
460 470 480 490 500
VPLMAAKVCI GSLHWLEEAE HFATVVIGLG EEAGESLPKG YLALGLTYSL
510 520 530 540 550
QATDATLKSK QDELHRKALQ TLERARELAP DDPQIIFYVA LQLALVRQIS
560 570 580 590 600
SAMERLQEAL TMCRDDANAL HLLALLFSAQ KYYQHALDVI NMAITEHPEN
610 620 630 640 650
FNLMFTKVKL EQVLKGPEEA LVTCRQMLRL WQTLYNFSQL GGLEKDGSFE
660 670 680 690 700
GLTVKKQNGI HLTLPDAHDA DSGSRRASSI AASRLEEAMS ELTLTTSVLK
710 720 730 740 750
QGPMQLWTTL EQIWLQAAEL FMEQRQLKEA GFCIQEAAGL FPTSHSVLYM
760 770 780 790 800
RGRLAEVKGS FEEAKQLYKE ALTVNPDGVR IMHSLGLMLS QLGHKSLAQK
810 820 830 840 850
VLRDAVERQS TFHEAWQGLG EVLQDQGQNE AAVDCFLTAL ELEASSPVLP

FSIIAREL
Length:858
Mass (Da):96,156
Last modified:March 1, 2003 - v1
Checksum:iAEE2C01FA7CA3589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040578 mRNA Translation: BAC30634.1
AK050263 mRNA Translation: BAC34153.1
AK080284 mRNA Translation: BAC37865.1
BC042512 mRNA Translation: AAH42512.2
CCDSiCCDS29016.1
RefSeqiNP_082915.1, NM_028639.3
UniGeneiMm.77396

Genome annotation databases

EnsembliENSMUST00000041110; ENSMUSP00000040771; ENSMUSG00000036918
GeneIDi225049
KEGGimmu:225049
UCSCiuc008duv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTTC7A_MOUSE
AccessioniPrimary (citable) accession number: Q8BGB2
Secondary accession number(s): Q80XT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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