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Protein

KRR1 small subunit processome component homolog

Gene

Krr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
KRR1 small subunit processome component homolog
Alternative name(s):
HIV-1 Rev-binding protein 2 homolog
KRR-R motif-containing protein 1
Gene namesi
Name:Krr1
Synonyms:Hrb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1289274 Krr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501151 – 380KRR1 small subunit processome component homologAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Cross-linki23Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BGA5
MaxQBiQ8BGA5
PaxDbiQ8BGA5
PeptideAtlasiQ8BGA5
PRIDEiQ8BGA5

PTM databases

iPTMnetiQ8BGA5
PhosphoSitePlusiQ8BGA5

Expressioni

Gene expression databases

BgeeiENSMUSG00000063334 Expressed in 293 organ(s), highest expression level in optic fissure
ExpressionAtlasiQ8BGA5 baseline and differential
GenevisibleiQ8BGA5 MM

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome.By similarity

Protein-protein interaction databases

BioGridi206745, 2 interactors
IntActiQ8BGA5, 1 interactor
MINTiQ8BGA5
STRINGi10090.ENSMUSP00000125746

Structurei

3D structure databases

ProteinModelPortaliQ8BGA5
SMRiQ8BGA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 205KHAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi246 – 380Lys-richAdd BLAST135

Sequence similaritiesi

Belongs to the KRR1 family.Curated

Phylogenomic databases

eggNOGiKOG2874 Eukaryota
COG1094 LUCA
GeneTreeiENSGT00390000018775
HOGENOMiHOG000116208
HOVERGENiHBG051924
InParanoidiQ8BGA5
KOiK06961
OMAiETMNNVH
OrthoDBiEOG091G0BTX
TreeFamiTF105745

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR036612 KH_dom_type_1_sf
IPR024166 rRNA_assembly_KRR1
PANTHERiPTHR12581 PTHR12581, 1 hit
PIRSFiPIRSF006515 KRR1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BGA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSAEAPAK EAQKRDSQPQ KQKRETQDEA ELLTVPDGWK EPAFSKEDNP
60 70 80 90 100
RGLLEESSFA TLFPKYREAY LKECWPLVQK ALNEHHVKAT LDLIEGSMTV
110 120 130 140 150
CTTKKTFDPY IIIRARDLIK LLARSVSFEQ AVRILQDDVA CDIIKIGSLV
160 170 180 190 200
RNKERFVKRR QRLIGPKGST LKALELLTNC YVMVQGNTVS AIGPFSGLKE
210 220 230 240 250
VRKVVLDTMK NIHPIYNIKT LMIKRELAKD SELRSQSWER FLPQFKHKNV
260 270 280 290 300
NKRKEPKKKS VKKEYTPFPP PQPESQIDKE LASGEYFLKA SQKKRQKMEA
310 320 330 340 350
IKAKQAEALT KRQEERNKAF IPPKEKPAVK PKEASTETKI DVAAIKEKVK
360 370 380
KAKTKKLGAL TAEEVKLKME ADEKKQKRKK
Length:380
Mass (Da):43,538
Last modified:March 1, 2003 - v1
Checksum:iB0A0F674F93F3C7D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZA0G3UZA0_MOUSE
KRR1 small subunit processome compo...
Krr1
323Annotation score:

Sequence cautioni

The sequence BAE27537 differs from that shown. Reason: Frameshift at position 332.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38G → V in AAH94236 (PubMed:15489334).Curated1
Sequence conflicti243P → Q in BAC27888 (PubMed:16141072).Curated1
Sequence conflicti331P → Q in BAE27537 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030560 mRNA Translation: BAC27022.1
AK032472 mRNA Translation: BAC27888.1
AK041854 mRNA Translation: BAC31083.1
AK146926 mRNA Translation: BAE27537.1 Frameshift.
AK168675 mRNA Translation: BAE40525.1
AC167231 Genomic DNA No translation available.
CH466539 Genomic DNA Translation: EDL21743.1
BC089510 mRNA Translation: AAH89510.1
BC094236 mRNA Translation: AAH94236.1
CCDSiCCDS24168.1
RefSeqiNP_848725.2, NM_178610.4
UniGeneiMm.34606

Genome annotation databases

EnsembliENSMUST00000163048; ENSMUSP00000125746; ENSMUSG00000063334
GeneIDi52705
KEGGimmu:52705
UCSCiuc007hag.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030560 mRNA Translation: BAC27022.1
AK032472 mRNA Translation: BAC27888.1
AK041854 mRNA Translation: BAC31083.1
AK146926 mRNA Translation: BAE27537.1 Frameshift.
AK168675 mRNA Translation: BAE40525.1
AC167231 Genomic DNA No translation available.
CH466539 Genomic DNA Translation: EDL21743.1
BC089510 mRNA Translation: AAH89510.1
BC094236 mRNA Translation: AAH94236.1
CCDSiCCDS24168.1
RefSeqiNP_848725.2, NM_178610.4
UniGeneiMm.34606

3D structure databases

ProteinModelPortaliQ8BGA5
SMRiQ8BGA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206745, 2 interactors
IntActiQ8BGA5, 1 interactor
MINTiQ8BGA5
STRINGi10090.ENSMUSP00000125746

PTM databases

iPTMnetiQ8BGA5
PhosphoSitePlusiQ8BGA5

Proteomic databases

EPDiQ8BGA5
MaxQBiQ8BGA5
PaxDbiQ8BGA5
PeptideAtlasiQ8BGA5
PRIDEiQ8BGA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163048; ENSMUSP00000125746; ENSMUSG00000063334
GeneIDi52705
KEGGimmu:52705
UCSCiuc007hag.2 mouse

Organism-specific databases

CTDi11103
MGIiMGI:1289274 Krr1

Phylogenomic databases

eggNOGiKOG2874 Eukaryota
COG1094 LUCA
GeneTreeiENSGT00390000018775
HOGENOMiHOG000116208
HOVERGENiHBG051924
InParanoidiQ8BGA5
KOiK06961
OMAiETMNNVH
OrthoDBiEOG091G0BTX
TreeFamiTF105745

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:Q8BGA5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063334 Expressed in 293 organ(s), highest expression level in optic fissure
ExpressionAtlasiQ8BGA5 baseline and differential
GenevisibleiQ8BGA5 MM

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR036612 KH_dom_type_1_sf
IPR024166 rRNA_assembly_KRR1
PANTHERiPTHR12581 PTHR12581, 1 hit
PIRSFiPIRSF006515 KRR1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRR1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA5
Secondary accession number(s): Q3UIG9
, Q52KQ6, Q5EBJ5, Q8C029
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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