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Protein

LHFPL tetraspan subfamily member 2 protein

Gene

Lhfpl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in female and male fertility. Involved in distal reproductive tract development (PubMed:26964900).1 Publication

GO - Biological processi

Keywordsi

Biological processFertilization

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Protein family/group databases

TCDBi1.A.82.1.2 the lhfpl tetraspan protein (ltsp) family

Names & Taxonomyi

Protein namesi
Recommended name:
LHFPL tetraspan subfamily member 2 proteinBy similarity
Alternative name(s):
Lipoma HMGIC fusion partner-like 2 proteinImported
Gene namesi
Name:Lhfpl2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145236 Lhfpl2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002447641 – 222LHFPL tetraspan subfamily member 2 proteinAdd BLAST222

Proteomic databases

MaxQBiQ8BGA2
PaxDbiQ8BGA2
PRIDEiQ8BGA2

PTM databases

PhosphoSitePlusiQ8BGA2
SwissPalmiQ8BGA2

Expressioni

Tissue specificityi

Expressed in the epithelium of the vas deferens (at protein level). Widely expressed (PubMed:26964900). Strongly expressed in heart, spleen, liver, kidney, thymus, testis, brain, lung, intestine, vagina, ovary and uterus (PubMed:26964900). Expressed in follicle cells of the ovary, epithelial cells of the oviduct, both luminal and glandular epithelial cells of the uterus, and epithelial cells of the vagina (PubMed:26964900).1 Publication

Gene expression databases

BgeeiENSMUSG00000045312 Expressed in 232 organ(s), highest expression level in metanephros
CleanExiMM_LHFPL2
ExpressionAtlasiQ8BGA2 baseline and differential
GenevisibleiQ8BGA2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062239

Structurei

3D structure databases

ProteinModelPortaliQ8BGA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026 Eukaryota
ENOG410XSUB LUCA
GeneTreeiENSGT00550000074479
HOGENOMiHOG000285972
HOVERGENiHBG054430
InParanoidiQ8BGA2
OMAiYPGEWKA
OrthoDBiEOG091G0J9C
PhylomeDBiQ8BGA2
TreeFamiTF321143

Family and domain databases

InterProiView protein in InterPro
IPR019372 LHFPL
PANTHERiPTHR12489 PTHR12489, 1 hit
PfamiView protein in Pfam
PF10242 L_HMGIC_fpl, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8BGA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCHVIVTCRS MLWTLLSIVV AFAELVAFMS ADWLIGKAKT RSGSGDEQAG
60 70 80 90 100
MNSEPHYLGI LCIRTPAMQQ VSRDTLCGTY AKSFGEIASG FWQATAIFLA
110 120 130 140 150
VGIFILCVVA LVSVFTMCVQ SIMRKSIFNV CGLLQGIAGL FLILGLILYP
160 170 180 190 200
AGWGCQKAID CGRYASPYKP GDCSLGWAFY TATGGTVLTF ICAVFSAQAE
210 220
IATSSDKVQE EIEEGKNLVC LL
Length:222
Mass (Da):23,873
Last modified:March 1, 2003 - v1
Checksum:iB105BF041868F1A9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z698D3Z698_MOUSE
LHFPL tetraspan subfamily member 2 ...
Lhfpl2
139Annotation score:
D3Z4C4D3Z4C4_MOUSE
LHFPL tetraspan subfamily member 2 ...
Lhfpl2
34Annotation score:
A0A1Y7VJ20A0A1Y7VJ20_MOUSE
LHFPL tetraspan subfamily member 2 ...
Lhfpl2
141Annotation score:
A0A1Y7VNJ3A0A1Y7VNJ3_MOUSE
LHFPL tetraspan subfamily member 2 ...
Lhfpl2
19Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti102G → E Causes malformations in the distal reproductive tract development in both female and male. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040389 mRNA Translation: AAH40389.1
AK030103 mRNA Translation: BAC26786.1
AK052969 mRNA Translation: BAC35225.1
AK087506 mRNA Translation: BAC39903.1
CCDSiCCDS26692.1
RefSeqiNP_766177.1, NM_172589.2
XP_011242941.1, XM_011244639.2
XP_011242942.1, XM_011244640.1
XP_011242943.1, XM_011244641.2
XP_011242944.1, XM_011244642.2
XP_011242945.1, XM_011244643.2
XP_011242946.1, XM_011244644.2
UniGeneiMm.316553

Genome annotation databases

EnsembliENSMUST00000054274; ENSMUSP00000062239; ENSMUSG00000045312
ENSMUST00000118195; ENSMUSP00000112655; ENSMUSG00000045312
ENSMUST00000121618; ENSMUSP00000113468; ENSMUSG00000045312
GeneIDi218454
KEGGimmu:218454
UCSCiuc007rlp.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040389 mRNA Translation: AAH40389.1
AK030103 mRNA Translation: BAC26786.1
AK052969 mRNA Translation: BAC35225.1
AK087506 mRNA Translation: BAC39903.1
CCDSiCCDS26692.1
RefSeqiNP_766177.1, NM_172589.2
XP_011242941.1, XM_011244639.2
XP_011242942.1, XM_011244640.1
XP_011242943.1, XM_011244641.2
XP_011242944.1, XM_011244642.2
XP_011242945.1, XM_011244643.2
XP_011242946.1, XM_011244644.2
UniGeneiMm.316553

3D structure databases

ProteinModelPortaliQ8BGA2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062239

Protein family/group databases

TCDBi1.A.82.1.2 the lhfpl tetraspan protein (ltsp) family

PTM databases

PhosphoSitePlusiQ8BGA2
SwissPalmiQ8BGA2

Proteomic databases

MaxQBiQ8BGA2
PaxDbiQ8BGA2
PRIDEiQ8BGA2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054274; ENSMUSP00000062239; ENSMUSG00000045312
ENSMUST00000118195; ENSMUSP00000112655; ENSMUSG00000045312
ENSMUST00000121618; ENSMUSP00000113468; ENSMUSG00000045312
GeneIDi218454
KEGGimmu:218454
UCSCiuc007rlp.1 mouse

Organism-specific databases

CTDi10184
MGIiMGI:2145236 Lhfpl2

Phylogenomic databases

eggNOGiKOG4026 Eukaryota
ENOG410XSUB LUCA
GeneTreeiENSGT00550000074479
HOGENOMiHOG000285972
HOVERGENiHBG054430
InParanoidiQ8BGA2
OMAiYPGEWKA
OrthoDBiEOG091G0J9C
PhylomeDBiQ8BGA2
TreeFamiTF321143

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Miscellaneous databases

PROiPR:Q8BGA2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045312 Expressed in 232 organ(s), highest expression level in metanephros
CleanExiMM_LHFPL2
ExpressionAtlasiQ8BGA2 baseline and differential
GenevisibleiQ8BGA2 MM

Family and domain databases

InterProiView protein in InterPro
IPR019372 LHFPL
PANTHERiPTHR12489 PTHR12489, 1 hit
PfamiView protein in Pfam
PF10242 L_HMGIC_fpl, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLHPL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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