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Protein

Protein ZNF365

Gene

Znf365

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis (PubMed:23912123). Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth (PubMed:24481677). Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (PubMed:25983680). Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (By similarity).By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 51C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurogenesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF365
Alternative name(s):
DISC1-binding zinc-finger protein1 Publication
Su48
Gene namesi
Name:Znf365
Synonyms:Dbz1 Publication, Kiaa0844, Zfp365
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143676 Zfp365

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Basket cells with reduced branches and short processes in the somatosensory cortex of adult knockout (KO) mice. Reduced expression of the gamma-aminobutyric acid-synthesizing enzymes Gad1 in the somatosensory cortex of KO mice (PubMed:23912123). Delayed myelination in the corpus callosum of KO mice during the postnatal period, but recovery by adulthood (PubMed:24481677). Decreased dendritic arborization and increased spine density dendrites in cortical pyramidal neurons of adult KO mice (PubMed:25983680).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763751 – 408Protein ZNF365Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei176PhosphothreonineCombined sources1
Modified residuei370PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BG89
PRIDEiQ8BG89

PTM databases

iPTMnetiQ8BG89
PhosphoSitePlusiQ8BG89

Expressioni

Tissue specificityi

Detected in several tissues, with highest levels in brain. Also expressed during embryonic development. Expressed in cerebral cortex, hippocampus, striatum, inferior colliculus and thalamus (PubMed:23912123).3 Publications

Developmental stagei

In the embryo at day 14.5 post-coitum, expressed in the basal, medial and lateral ganglionic eminences of the cerebral cortex, but not in the caudal ganglionic eminence (PubMed:23912123). Expressed in the corpus callosum from postnatal day 7 (PD7) to PD56 with a peak at PD14 (PubMed:24481677).2 Publications

Inductioni

Induced by gamma irradiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000037855 Expressed in 159 organ(s), highest expression level in visual cortex
CleanExiMM_ZFP365
GenevisibleiQ8BG89 MM

Interactioni

Subunit structurei

Homodimer. Interacts with NDE1 and NDEL1 (By similarity). Interacts with DISC1. Interacts with PARP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067197

Structurei

3D structure databases

ProteinModelPortaliQ8BG89
SMRiQ8BG89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili170 – 298Sequence analysisAdd BLAST129

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 51C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH1N Eukaryota
ENOG4111IHT LUCA
GeneTreeiENSGT00530000063713
HOGENOMiHOG000155791
HOVERGENiHBG094181
InParanoidiQ8BG89
KOiK16737
OMAiTHFHPKG
OrthoDBiEOG091G0BHK
PhylomeDBiQ8BG89
TreeFamiTF329439

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BG89-1) [UniParc]FASTAAdd to basket
Also known as: ZNF365a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQQTTFEESR YHWQDSLENV AVCLPFRCPR CGDHTRFRSL SSLRAHLEFS
60 70 80 90 100
HSYEERTLLT KCSLLPSLKD TELLRSSELP KQGKVLRGHA KVTKQKSSYV
110 120 130 140 150
NLYSISHGHS KDTKPFEMVA ERPVSYVQTY TAVDIRADSL DAPCASPGLP
160 170 180 190 200
TQDTKAAFEA HVREKFNRMV EAVDRTIEKR IDKLTKELAQ KTAELLEVRA
210 220 230 240 250
AFAQLTQKKQ EVQRRERALN KQVDVAVEMI AVLKQRLTES EEELLRKEEE
260 270 280 290 300
VVTFNHFLEA AAEKEVQGKA RLQDFIENLL QRVELAEKQL EYYQSQQASG
310 320 330 340 350
FSCDTSEHML TDIPSNRKPR CLSRGHQHSV CNHPEMRAHF HLKGRSYLKK
360 370 380 390 400
AKDERAGMQP AKAIHEPAES PREFFRPAKK GEHLGLSRKG NFRPKMAKKK

PTAIVNII
Length:408
Mass (Da):46,860
Last modified:March 1, 2003 - v1
Checksum:iB4E18F21EC340E26
GO
Isoform 2 (identifier: Q8BG89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-332: LTDIPSNRKPRCLSRGHQHSVCN → VSPLPVSHPMAPPEYSQNEPRQS
     333-408: Missing.

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):38,109
Checksum:iCBF39480F0AB2C78
GO

Sequence cautioni

The sequence BAC65669 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → P in AAQ11828 (PubMed:16617106).Curated1
Sequence conflicti97S → P in BAC65669 (PubMed:12693553).Curated1
Sequence conflicti97S → P in BAC31866 (PubMed:16141072).Curated1
Sequence conflicti309Missing in BAC65669 (PubMed:12693553).Curated1
Sequence conflicti336M → L in AAQ11828 (PubMed:16617106).Curated1
Sequence conflicti336M → L in BAC65669 (PubMed:12693553).Curated1
Sequence conflicti336M → L in BAC31866 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016601310 – 332LTDIP…HSVCN → VSPLPVSHPMAPPEYSQNEP RQS in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_016602333 – 408Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ516033 mRNA Translation: CAD56774.1
AF543761 mRNA Translation: AAQ11828.1
AK122387 mRNA Translation: BAC65669.1 Different initiation.
AK031846 mRNA Translation: BAC27578.1
AK033892 mRNA Translation: BAC28505.1
AK044322 mRNA Translation: BAC31866.1
AK077316 mRNA Translation: BAC36745.1
BC080272 mRNA Translation: AAH80272.1
CCDSiCCDS23903.1 [Q8BG89-1]
RefSeqiNP_848794.1, NM_178679.2 [Q8BG89-1]
UniGeneiMm.268346

Genome annotation databases

EnsembliENSMUST00000064656; ENSMUSP00000067197; ENSMUSG00000037855 [Q8BG89-1]
GeneIDi216049
KEGGimmu:216049
UCSCiuc007fmb.1 mouse [Q8BG89-1]
uc007fmc.1 mouse [Q8BG89-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ516033 mRNA Translation: CAD56774.1
AF543761 mRNA Translation: AAQ11828.1
AK122387 mRNA Translation: BAC65669.1 Different initiation.
AK031846 mRNA Translation: BAC27578.1
AK033892 mRNA Translation: BAC28505.1
AK044322 mRNA Translation: BAC31866.1
AK077316 mRNA Translation: BAC36745.1
BC080272 mRNA Translation: AAH80272.1
CCDSiCCDS23903.1 [Q8BG89-1]
RefSeqiNP_848794.1, NM_178679.2 [Q8BG89-1]
UniGeneiMm.268346

3D structure databases

ProteinModelPortaliQ8BG89
SMRiQ8BG89
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067197

PTM databases

iPTMnetiQ8BG89
PhosphoSitePlusiQ8BG89

Proteomic databases

PaxDbiQ8BG89
PRIDEiQ8BG89

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064656; ENSMUSP00000067197; ENSMUSG00000037855 [Q8BG89-1]
GeneIDi216049
KEGGimmu:216049
UCSCiuc007fmb.1 mouse [Q8BG89-1]
uc007fmc.1 mouse [Q8BG89-2]

Organism-specific databases

CTDi216049
MGIiMGI:2143676 Zfp365
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IH1N Eukaryota
ENOG4111IHT LUCA
GeneTreeiENSGT00530000063713
HOGENOMiHOG000155791
HOVERGENiHBG094181
InParanoidiQ8BG89
KOiK16737
OMAiTHFHPKG
OrthoDBiEOG091G0BHK
PhylomeDBiQ8BG89
TreeFamiTF329439

Miscellaneous databases

PROiPR:Q8BG89
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037855 Expressed in 159 organ(s), highest expression level in visual cortex
CleanExiMM_ZFP365
GenevisibleiQ8BG89 MM

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiZN365_MOUSE
AccessioniPrimary (citable) accession number: Q8BG89
Secondary accession number(s): Q80TQ4, Q8BK39, Q8BXT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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