UniProtKB - Q8BG84 (LAIR1_MOUSE)
Leukocyte-associated immunoglobulin-like receptor 1
Lair1
Functioni
Keywordsi
Molecular function | Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte-associated immunoglobulin-like receptor 1Short name: LAIR-1 Short name: mLAIR1 Alternative name(s): CD_antigen: CD305 |
Gene namesi | Name:Lair1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105492, Lair1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 144 | ExtracellularSequence analysisAdd BLAST | 123 | |
Transmembranei | 145 – 165 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 166 – 263 | CytoplasmicSequence analysisAdd BLAST | 98 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000250683 | 22 – 263 | Leukocyte-associated immunoglobulin-like receptor 1Add BLAST | 242 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 49 ↔ 99 | PROSITE-ProRule annotation | ||
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 228 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 257 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q8BG84 |
PRIDEi | Q8BG84 |
PTM databases
GlyGeni | Q8BG84, 2 sites |
PhosphoSitePlusi | Q8BG84 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000055541, Expressed in bone marrow macrophage and 144 other tissues |
Genevisiblei | Q8BG84, MM |
Interactioni
Subunit structurei
Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive.
Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important (By similarity).
By similarityProtein-protein interaction databases
DIPi | DIP-61634N |
IntActi | Q8BG84, 1 interactor |
STRINGi | 10090.ENSMUSP00000083589 |
Miscellaneous databases
RNActi | Q8BG84, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8BG84 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 115 | Ig-like C2-typeAdd BLAST | 89 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 226 – 231 | ITIM motif 1 | 6 | |
Motifi | 255 – 260 | ITIM motif 2 | 6 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TBGD, Eukaryota |
GeneTreei | ENSGT00940000162693 |
HOGENOMi | CLU_1712690_0_0_1 |
InParanoidi | Q8BG84 |
OMAi | SHNDHAP |
OrthoDBi | 1481318at2759 |
PhylomeDBi | Q8BG84 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLHPVILLV LVLCLGWKIN TQEGSLPDIT IFPNSSLMIS QGTFVTVVCS
60 70 80 90 100
YSDKHDLYNM VRLEKDGSTF MEKSTEPYKT EDEFEIGPVN ETITGHYSCI
110 120 130 140 150
YSKGITWSER SKTLELKVIK ENVIQTPAPG PTSDTSWLKT YSIYIFTVVS
160 170 180 190 200
VIFLLCLSAL LFCFLRHRQK KQGLPNNKRQ QQRPEERLNL ATNGLEMTPD
210 220 230 240 250
IVADDRLPED RWTETWTPVA GDLQEVTYIQ LDHHSLTQRA VGAVTSQSTD
260
MAESSTYAAI IRH
The sequence of this isoform differs from the canonical sequence as follows:
25-56: SLPDITIFPNSSLMISQGTFVTVVCSYSDKHD → ELCLWFLLYPWATLELIMCTWDAWKETLEYFL
57-263: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG8JL64 | G8JL64_MOUSE | Leukocyte-associated immunoglobulin... | Lair1 | 246 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 143 – 145 | IYI → MYM in BAC25505 (PubMed:16141072).Curated | 3 | |
Sequence conflicti | 149 | V → G in BAC25505 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 154 | L → P in BAC25505 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 263 | H → R in AAH25901 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020715 | 24 – 172 | Missing in isoform 5. 1 PublicationAdd BLAST | 149 | |
Alternative sequenceiVSP_020716 | 24 – 133 | Missing in isoform 2. 2 PublicationsAdd BLAST | 110 | |
Alternative sequenceiVSP_020714 | 25 – 56 | SLPDI…SDKHD → ELCLWFLLYPWATLELIMCT WDAWKETLEYFL in isoform 3. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_020719 | 57 – 263 | Missing in isoform 3. 1 PublicationAdd BLAST | 207 | |
Alternative sequenceiVSP_020718 | 134 – 172 | Missing in isoform 6. 1 PublicationAdd BLAST | 39 |
Sequence databases
Genome annotation databases
Ensembli | ENSMUST00000068865; ENSMUSP00000070712; ENSMUSG00000055541 [Q8BG84-2] ENSMUST00000086401; ENSMUSP00000083589; ENSMUSG00000055541 [Q8BG84-1] ENSMUST00000108600; ENSMUSP00000104241; ENSMUSG00000055541 [Q8BG84-6] ENSMUST00000131126; ENSMUSP00000121738; ENSMUSG00000055541 [Q8BG84-3] ENSMUST00000136616; ENSMUSP00000122037; ENSMUSG00000055541 [Q8BG84-3] ENSMUST00000149395; ENSMUSP00000116800; ENSMUSG00000055541 [Q8BG84-3] ENSMUST00000205296; ENSMUSP00000145940; ENSMUSG00000055541 [Q8BG84-5] |
GeneIDi | 52855 |
KEGGi | mmu:52855 |
UCSCi | uc009ews.2, mouse [Q8BG84-2] uc009ewt.2, mouse [Q8BG84-1] uc012ewk.1, mouse [Q8BG84-5] uc012ewl.1, mouse [Q8BG84-6] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4ESK | X-ray | 1.76 | A/B/C/D | 22-121 | [»] | |
4ETY | X-ray | 1.90 | A/B/C/D | 22-133 | [»] | |
SMRi | Q8BG84 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-61634N |
IntActi | Q8BG84, 1 interactor |
STRINGi | 10090.ENSMUSP00000083589 |
PTM databases
GlyGeni | Q8BG84, 2 sites |
PhosphoSitePlusi | Q8BG84 |
Proteomic databases
PaxDbi | Q8BG84 |
PRIDEi | Q8BG84 |
Protocols and materials databases
Antibodypediai | 2596, 785 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000068865; ENSMUSP00000070712; ENSMUSG00000055541 [Q8BG84-2] ENSMUST00000086401; ENSMUSP00000083589; ENSMUSG00000055541 [Q8BG84-1] ENSMUST00000108600; ENSMUSP00000104241; ENSMUSG00000055541 [Q8BG84-6] ENSMUST00000131126; ENSMUSP00000121738; ENSMUSG00000055541 [Q8BG84-3] ENSMUST00000136616; ENSMUSP00000122037; ENSMUSG00000055541 [Q8BG84-3] ENSMUST00000149395; ENSMUSP00000116800; ENSMUSG00000055541 [Q8BG84-3] ENSMUST00000205296; ENSMUSP00000145940; ENSMUSG00000055541 [Q8BG84-5] |
GeneIDi | 52855 |
KEGGi | mmu:52855 |
UCSCi | uc009ews.2, mouse [Q8BG84-2] uc009ewt.2, mouse [Q8BG84-1] uc012ewk.1, mouse [Q8BG84-5] uc012ewl.1, mouse [Q8BG84-6] |
Organism-specific databases
CTDi | 3903 |
MGIi | MGI:105492, Lair1 |
Phylogenomic databases
eggNOGi | ENOG502TBGD, Eukaryota |
GeneTreei | ENSGT00940000162693 |
HOGENOMi | CLU_1712690_0_0_1 |
InParanoidi | Q8BG84 |
OMAi | SHNDHAP |
OrthoDBi | 1481318at2759 |
PhylomeDBi | Q8BG84 |
Miscellaneous databases
BioGRID-ORCSi | 52855, 0 hits in 17 CRISPR screens |
ChiTaRSi | Lair1, mouse |
PROi | PR:Q8BG84 |
RNActi | Q8BG84, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055541, Expressed in bone marrow macrophage and 144 other tissues |
Genevisiblei | Q8BG84, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAIR1_MOUSE | |
Accessioni | Q8BG84Primary (citable) accession number: Q8BG84 Secondary accession number(s): Q80UN5 Q8CEP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references