Txnip

Functionⁱ

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.By similarity2 Publications

GO - Molecular functionⁱ

enzyme inhibitor activity
Source: MGI
Inferred from direct assayⁱ
- 10843682
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cellular response to tumor cell Source: UniProtKB
keratinocyte differentiation Source: MGI
negative regulation of cell division Source: UniProtKB
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 18555775
platelet-derived growth factor receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 17143286
positive regulation of apoptotic process Source: MGI
protein import into nucleus
Source: MGI
Inferred from mutant phenotypeⁱ
- 18555775
regulation of cell proliferation Source: MGI
response to calcium ion Source: Ensembl
response to estradiol Source: Ensembl
response to glucose Source: Ensembl
response to hydrogen peroxide Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to oxidative stress
Source: MGI
Inferred from direct assayⁱ
- 10843682
response to progesterone Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Transcription, Transcription regulation

Biological process

Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-844456 The NLRP3 inflammasome

Reactomeⁱ

R-MMU-844456 The NLRP3 inflammasome

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thioredoxin-interacting protein Alternative name(s): Vitamin D3 up-regulated protein 1
Gene namesⁱ	Name:Txnip Synonyms:Vdup1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1889549 Txnip

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Keywords - Diseaseⁱ

Tumor suppressor

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000250490	1 – 397	Thioredoxin-interacting proteinAdd BLAST		397

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	63	InterchainBy similarity
Cross-linkⁱ	213	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	362	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.By similarity

Keywords - PTMⁱ

Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q8BG60
PeptideAtlas More...PeptideAtlasⁱ	Q8BG60
PRIDEⁱ	Q8BG60

PTM databases

iPTMnetⁱ	Q8BG60
PhosphoSitePlusⁱ	Q8BG60

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000038393 Expressed in 313 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	MM_TXNIP
Genevisibleⁱ	Q8BG60 MM

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Prmt1	Q9JIF0	2	EBI-10689732,EBI-519055

With

Entry

#Exp.

IntAct

Notes

Prmt1

Q9JIF0

2

EBI-10689732,EBI-519055

GO - Molecular functionⁱ

ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	207912, 1 interactor
IntActⁱ	Q8BG60, 1 interactor
STRINGⁱ	10090.ENSMUSP00000102710

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BG60
SMRⁱ	Q8BG60
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3780 Eukaryota ENOG41102NY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074356
HOGENOMⁱ	HOG000237328
HOVERGENⁱ	HBG066469
InParanoidⁱ	Q8BG60
KEGG Orthology (KO) More...KOⁱ	K20910
OMAⁱ	KPSILGC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B0Y
PhylomeDBⁱ	Q8BG60
TreeFamⁱ	TF313650

Family and domain databases

Gene3Dⁱ	2.60.40.640, 2 hits
InterProⁱ	View protein in InterPro IPR011021 Arrestin-like_N IPR014752 Arrestin_C IPR011022 Arrestin_C-like IPR014756 Ig_E-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02752 Arrestin_C, 1 hit PF00339 Arrestin_N, 1 hit
SMARTⁱ	View protein in SMART SM01017 Arrestin_C, 1 hit
SUPFAMⁱ	SSF81296 SSF81296, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8BG60-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG 
        60         70         80         90        100
VAKVLWMQGS QQCKQTLDYL RYEDTLLLEE QPTAGENEMV IMRPGNKYEY 
       110        120        130        140        150
KFGFELPQGP LGTSFKGKYG CVDYWVKAFL DRPSQPTQEA KKNFEVMDLV 
       160        170        180        190        200
DVNTPDLMAP VSAKKEKKVS CMFIPDGRVS VSARIDRKGF CEGDDISIHA 
       210        220        230        240        250
DFENTCSRIV VPKAAIVARH TYLANGQTKV FTQKLSSVRG NHIISGTCAS 
       260        270        280        290        300
WRGKSLRVQK IRPSILGCNI LKVEYSLLIY VSVPGSKKVI LDLPLVIGSR 
       310        320        330        340        350
SGLSSRTSSM ASRTSSEMSW IDLNIPDTPE APPCYMDIIP EDHRLESPTT 
       360        370        380        390 
PLLDDVDDSQ DSPIFMYAPE FQFMPPPTYT EVDPCVLNNN NNNNNVQ

Length:397

Mass (Da):44,363

Last modified:March 1, 2003 - v1

Checksum:ⁱC160781B207C99A6

GO

Isoform 2 (identifier: Q8BG60-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
84-84: Missing.

« Hide

        10         20         30         40         50
MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG 
        60         70         80         90        100
VAKVLWMQGS QQCKQTLDYL RYEDTLLLEE QPTGENEMVI MRPGNKYEYK 
       110        120        130        140        150
FGFELPQGPL GTSFKGKYGC VDYWVKAFLD RPSQPTQEAK KNFEVMDLVD 
       160        170        180        190        200
VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV SARIDRKGFC EGDDISIHAD 
       210        220        230        240        250
FENTCSRIVV PKAAIVARHT YLANGQTKVF TQKLSSVRGN HIISGTCASW 
       260        270        280        290        300
RGKSLRVQKI RPSILGCNIL KVEYSLLIYV SVPGSKKVIL DLPLVIGSRS 
       310        320        330        340        350
GLSSRTSSMA SRTSSEMSWI DLNIPDTPEA PPCYMDIIPE DHRLESPTTP 
       360        370        380        390 
LLDDVDDSQD SPIFMYAPEF QFMPPPTYTE VDPCVLNNNN NNNNVQ

Show »

Length:396

Mass (Da):44,292

Checksum:ⁱ7F8C2AE2CA5C432A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	79	E → G in BAB23444 (PubMed:16141072).Curated	1
Sequence conflictⁱ	165	K → E in AAD48499 (PubMed:10843682).Curated	1
Sequence conflictⁱ	175	P → R in AAD48499 (PubMed:10843682).Curated	1
Sequence conflictⁱ	308	S → F in AAG32665 (PubMed:11376942).Curated	1
Sequence conflictⁱ	308	S → F in AAG32666 (PubMed:11376942).Curated	1
Sequence conflictⁱ	395	N → NN in AAH31850 (PubMed:15489334).Curated	1
Sequence conflictⁱ	395	Missing in AAD48499 (PubMed:10843682).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_020653	84	Missing in isoform 2. 4 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF173681 mRNA Translation: AAD48499.1 AF282825 Genomic DNA Translation: AAG32665.1 AF282826 mRNA Translation: AAG32666.1 AK004653 mRNA Translation: BAB23444.1 AK082476 mRNA Translation: BAC38504.1 AK088870 mRNA Translation: BAC40625.1 AK089304 mRNA Translation: BAC40834.1 AK089351 mRNA Translation: BAC40850.1 AK089403 mRNA Translation: BAC40868.1 AK155517 mRNA Translation: BAE33304.1 AK171205 mRNA Translation: BAE42311.1 AK171312 mRNA Translation: BAE42386.1 AK171425 mRNA Translation: BAE42444.1 AK171456 mRNA Translation: BAE42465.1 AK171464 mRNA Translation: BAE42470.1 AK171527 mRNA Translation: BAE42508.1 BC031850 mRNA Translation: AAH31850.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17640.1 [Q8BG60-2] CCDS38555.1 [Q8BG60-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001009935.1, NM_001009935.2 [Q8BG60-1] NP_076208.2, NM_023719.2 [Q8BG60-2]
UniGeneⁱ	Mm.410189 Mm.475353

Genome annotation databases

Ensemblⁱ	ENSMUST00000049093; ENSMUSP00000041467; ENSMUSG00000038393 [Q8BG60-2] ENSMUST00000074519; ENSMUSP00000102710; ENSMUSG00000038393 [Q8BG60-1]
GeneIDⁱ	56338
KEGGⁱ	mmu:56338
UCSC genome browser More...UCSCⁱ	uc008qnc.2 mouse [Q8BG60-1] uc008qnd.2 mouse [Q8BG60-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q8BG60	Thioredoxin-interacting protein	)	HUMAN		391	UniRef90_Q9H3M7
Thioredoxin-interacting protein		RAT		394
Thioredoxin-interacting protein		PIG		391
Thioredoxin-interacting protein		PONAB		391
Thioredoxin interacting protein		PANTR		391
+129

Protein	Similar proteins		Species	Score	Length	Source
Q8BG60	Thioredoxin-interacting protein	)	HUMAN		391	UniRef50_Q9H3M7
Thioredoxin-interacting protein		RAT		394
Thioredoxin-interacting protein		PONAB		391
Thioredoxin-interacting protein		PIG		391
Thioredoxin interacting protein		PANTR		391
+332

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF173681 mRNA Translation: AAD48499.1 AF282825 Genomic DNA Translation: AAG32665.1 AF282826 mRNA Translation: AAG32666.1 AK004653 mRNA Translation: BAB23444.1 AK082476 mRNA Translation: BAC38504.1 AK088870 mRNA Translation: BAC40625.1 AK089304 mRNA Translation: BAC40834.1 AK089351 mRNA Translation: BAC40850.1 AK089403 mRNA Translation: BAC40868.1 AK155517 mRNA Translation: BAE33304.1 AK171205 mRNA Translation: BAE42311.1 AK171312 mRNA Translation: BAE42386.1 AK171425 mRNA Translation: BAE42444.1 AK171456 mRNA Translation: BAE42465.1 AK171464 mRNA Translation: BAE42470.1 AK171527 mRNA Translation: BAE42508.1 BC031850 mRNA Translation: AAH31850.1
CCDSⁱ	CCDS17640.1 [Q8BG60-2] CCDS38555.1 [Q8BG60-1]
RefSeqⁱ	NP_001009935.1, NM_001009935.2 [Q8BG60-1] NP_076208.2, NM_023719.2 [Q8BG60-2]
UniGeneⁱ	Mm.410189 Mm.475353

3D structure databases

ProteinModelPortalⁱ	Q8BG60
SMRⁱ	Q8BG60
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207912, 1 interactor
IntActⁱ	Q8BG60, 1 interactor
STRINGⁱ	10090.ENSMUSP00000102710

PTM databases

iPTMnetⁱ	Q8BG60
PhosphoSitePlusⁱ	Q8BG60

Proteomic databases

PaxDbⁱ	Q8BG60
PeptideAtlasⁱ	Q8BG60
PRIDEⁱ	Q8BG60

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56338
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000049093; ENSMUSP00000041467; ENSMUSG00000038393 [Q8BG60-2] ENSMUST00000074519; ENSMUSP00000102710; ENSMUSG00000038393 [Q8BG60-1]
GeneIDⁱ	56338
KEGGⁱ	mmu:56338
UCSCⁱ	uc008qnc.2 mouse [Q8BG60-1] uc008qnd.2 mouse [Q8BG60-2]

Organism-specific databases

CTDⁱ	10628
MGIⁱ	MGI:1889549 Txnip

Phylogenomic databases

eggNOGⁱ	KOG3780 Eukaryota ENOG41102NY LUCA
GeneTreeⁱ	ENSGT00550000074356
HOGENOMⁱ	HOG000237328
HOVERGENⁱ	HBG066469
InParanoidⁱ	Q8BG60
KOⁱ	K20910
OMAⁱ	KPSILGC
OrthoDBⁱ	EOG091G0B0Y
PhylomeDBⁱ	Q8BG60
TreeFamⁱ	TF313650

Enzyme and pathway databases

Reactomeⁱ	R-MMU-844456 The NLRP3 inflammasome

Reactomeⁱ

R-MMU-844456 The NLRP3 inflammasome

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BG60
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038393 Expressed in 313 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	MM_TXNIP
Genevisibleⁱ	Q8BG60 MM

Family and domain databases

Gene3Dⁱ	2.60.40.640, 2 hits
InterProⁱ	View protein in InterPro IPR011021 Arrestin-like_N IPR014752 Arrestin_C IPR011022 Arrestin_C-like IPR014756 Ig_E-set
Pfamⁱ	View protein in Pfam PF02752 Arrestin_C, 1 hit PF00339 Arrestin_N, 1 hit
SMARTⁱ	View protein in SMART SM01017 Arrestin_C, 1 hit
SUPFAMⁱ	SSF81296 SSF81296, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TXNIP_MOUSE
Accessionⁱ	Q8BG60Primary (citable) accession number: Q8BG60 Secondary accession number(s): Q8BGQ0 , Q8K2B2, Q9DC00, Q9EP90, Q9R115
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8BG60 (TXNIP_MOUSE)

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Thioredoxin-interacting protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ