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Entry version 137 (02 Dec 2020)
Sequence version 2 (19 Jul 2004)
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Protein

RUN and SH3 domain-containing protein 1

Gene

Rusc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RUN and SH3 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rusc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919546, Rusc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Microtubule, Nucleus, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975331 – 893RUN and SH3 domain-containing protein 1Add BLAST893

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues following nuclear translocation.By similarity
Polyubiquitinated; polyubiquitination involves TRAF6.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BG26

PRoteomics IDEntifications database

More...
PRIDEi
Q8BG26

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BG26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BG26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, brain stem and spinal chord (at protein level).

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at 15 dpc in hippocampal, cortical and cerebellar brain, and brain stem and spinal chord. At 18 dpc, expression strongly overlaps with TUBB3 expression in post-mitotic neurons throughout the entire brain. Expression levels increase to 18 dpc/P1 after which the levels decline in the hippocampus, cerebellum and brain stem and spinal chord into adulthood while remaining high in the cortex.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041263, Expressed in substantia nigra and 307 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BG26, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IKBKG and TRAF6 (By similarity).

Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8BG26, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000088447

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BG26, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BG26

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini515 – 659RUNPROSITE-ProRule annotationAdd BLAST145
Domaini835 – 893SH3PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni463 – 598Interaction with TRAF6By similarityAdd BLAST136
Regioni599 – 665Interaction with IKBKGBy similarityAdd BLAST67

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RUN domain is necessary for NGF induced nuclear redistribution.By similarity

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWTC, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141033

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017252_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BG26

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKTNTGI

Database of Orthologous Groups

More...
OrthoDBi
373320at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BG26

TreeFam database of animal gene trees

More...
TreeFami
TF332235

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.900, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02759, RUN, 1 hit
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00593, RUN, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140741, SSF140741, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50826, RUN, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BG26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSPQRALLC NLNHIHLQHV SLGLHLSRRP ELREGPLSTP PPPGDTGGKE
60 70 80 90 100
SRGPCSGTLV DANSNSPAVP CRCCQEHGSS IENQQDPSQE EEAVSPSDPG
110 120 130 140 150
CSSSLSSCSD LSPDESPVSV YSRDLPGNED ANPQPSTLEL GSPLAPAGPS
160 170 180 190 200
TCSPDSFCCS PDSCSGISSP PGPDLDSNCN ALTTCQDLPS PGLEEEEDSG
210 220 230 240 250
EQDLATSELS ETEDGRIDAG KAEPSWKINP IWKIDTEKTE AGWKTIEDSD
260 270 280 290 300
SGRKTDENTN SSLKTESGKL ASCLNTNSGS KIDAGKTDGG WRGDVSQEPV
310 320 330 340 350
PHRTITSFHE LAQKRKRGPG LPLVPQAKKD RSDWLIVFSP DTELPPTGSL
360 370 380 390 400
GGSLAPPREV TTFKELRSRS RAQPPPVPPR DPPAGWALVP PRPPPPPVPP
410 420 430 440 450
RRKKNRLGLQ PIAEGLSEEG RAASPRAGEE ASASQEPEEP RAHAVVRSSW
460 470 480 490 500
SFAGVPGAQR LWMAEAQSGT GQLQEQKKGL LIAVSASVDK IISHFGAARN
510 520 530 540 550
LVQKAQLGDS RLSPDVGHLV LTTLCPALHA LVADGLKPFR KDLITGQRRS
560 570 580 590 600
SPWSVVEASV KPGSCTHSMG SLYSQVSRLA PLSSSRSRFH AFILGLLNTK
610 620 630 640 650
QLELWFSSLQ EDAGLLSLLY LPTGFFSLAR GSCPSLATEL LLLLQPLSVL
660 670 680 690 700
TFHLDLLFEH HHHLPVGLQQ APAPSCPPPA LQQTMQAVLH WGERLAQSLR
710 720 730 740 750
GTSGESTTDS STPSARPPAG SWWDQLTQAS RVYASGGTEG FPLLRWGPRR
760 770 780 790 800
HGTTAEAAQE APPPTEQTTP GRSVWLGRLF GVPGCPSETE SGAFKSRRPS
810 820 830 840 850
SWLPPTVSVL ALVKRGTPPE TPPEALVSSP GSVVQADRAV RALCDHTAAG
860 870 880 890
PDQLSFQRGE LLRVIATVDE DWLRCGRDGV EGLVPVGYTS LVL
Length:893
Mass (Da):95,195
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7CB4102A3CFAAB2
GO
Isoform 2 (identifier: Q8BG26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-462: Missing.

Show »
Length:431
Mass (Da):46,158
Checksum:iCFA15969F67C3FDC
GO
Isoform 3 (identifier: Q8BG26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-446: VV → VAGPSLFPRP...RRPPPPPRQL

Show »
Length:1,030
Mass (Da):109,515
Checksum:i358BB46D40340220
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGQ9A0A0G2JGQ9_MOUSE
RUN and SH3 domain-containing prote...
Rusc1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JE41A0A0G2JE41_MOUSE
RUN and SH3 domain-containing prote...
Rusc1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC27820 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC30411 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC31333 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti345P → Q in BAC27820 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0108561 – 462Missing in isoform 2. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_010857445 – 446VV → VAGPSLFPRPPVFRFSADGR PLLEGGGAGAPGSLLFTPLT GWSNSRLRLLGAASPPEEQL LPVRLSPVGAYSPPTRGALP CLASPELALLLSPLFPRSST FPAAAPLPRQVPAPPLPTPP CPPTAPRWTRRPPPPPRQL in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK032334 mRNA Translation: BAC27820.1 Different initiation.
AK039664 mRNA Translation: BAC30411.1 Different initiation.
AK042689 mRNA Translation: BAC31333.1 Sequence problems.
BC056360 mRNA Translation: AAH56360.1
BC057034 mRNA Translation: AAH57034.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38485.1 [Q8BG26-1]
CCDS38486.1 [Q8BG26-3]
CCDS50956.1 [Q8BG26-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001077276.1, NM_001083807.1 [Q8BG26-1]
NP_001077277.1, NM_001083808.1 [Q8BG26-2]
NP_082464.2, NM_028188.2 [Q8BG26-3]
XP_006502197.1, XM_006502134.3 [Q8BG26-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000052539; ENSMUSP00000056640; ENSMUSG00000041263 [Q8BG26-1]
ENSMUST00000090929; ENSMUSP00000088447; ENSMUSG00000041263 [Q8BG26-3]
ENSMUST00000166687; ENSMUSP00000130477; ENSMUSG00000041263 [Q8BG26-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72296

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72296

UCSC genome browser

More...
UCSCi
uc008pxm.1, mouse [Q8BG26-3]
uc008pxn.1, mouse [Q8BG26-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032334 mRNA Translation: BAC27820.1 Different initiation.
AK039664 mRNA Translation: BAC30411.1 Different initiation.
AK042689 mRNA Translation: BAC31333.1 Sequence problems.
BC056360 mRNA Translation: AAH56360.1
BC057034 mRNA Translation: AAH57034.1
CCDSiCCDS38485.1 [Q8BG26-1]
CCDS38486.1 [Q8BG26-3]
CCDS50956.1 [Q8BG26-2]
RefSeqiNP_001077276.1, NM_001083807.1 [Q8BG26-1]
NP_001077277.1, NM_001083808.1 [Q8BG26-2]
NP_082464.2, NM_028188.2 [Q8BG26-3]
XP_006502197.1, XM_006502134.3 [Q8BG26-2]

3D structure databases

SMRiQ8BG26
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8BG26, 5 interactors
STRINGi10090.ENSMUSP00000088447

PTM databases

iPTMnetiQ8BG26
PhosphoSitePlusiQ8BG26

Proteomic databases

PaxDbiQ8BG26
PRIDEiQ8BG26

Genome annotation databases

EnsembliENSMUST00000052539; ENSMUSP00000056640; ENSMUSG00000041263 [Q8BG26-1]
ENSMUST00000090929; ENSMUSP00000088447; ENSMUSG00000041263 [Q8BG26-3]
ENSMUST00000166687; ENSMUSP00000130477; ENSMUSG00000041263 [Q8BG26-2]
GeneIDi72296
KEGGimmu:72296
UCSCiuc008pxm.1, mouse [Q8BG26-3]
uc008pxn.1, mouse [Q8BG26-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23623
MGIiMGI:1919546, Rusc1

Phylogenomic databases

eggNOGiENOG502QWTC, Eukaryota
GeneTreeiENSGT00900000141033
HOGENOMiCLU_017252_0_0_1
InParanoidiQ8BG26
OMAiWKTNTGI
OrthoDBi373320at2759
PhylomeDBiQ8BG26
TreeFamiTF332235

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
72296, 2 hits in 15 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rusc1, mouse

Protein Ontology

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PROi
PR:Q8BG26
RNActiQ8BG26, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041263, Expressed in substantia nigra and 307 other tissues
GenevisibleiQ8BG26, MM

Family and domain databases

Gene3Di1.20.58.900, 1 hit
InterProiView protein in InterPro
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF02759, RUN, 1 hit
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00593, RUN, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF140741, SSF140741, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50826, RUN, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUSC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BG26
Secondary accession number(s): Q6PHT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: December 2, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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