Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleolar protein 12

Gene

Nol12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind to 28S rRNA. In vitro binds single-stranded nucleic acids.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 12
Alternative name(s):
Nucleolar protein of 25 kDa
Gene namesi
Name:Nol12
Synonyms:Nop25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146285 Nol12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002712081 – 217Nucleolar protein 12Add BLAST217

Proteomic databases

EPDiQ8BG17
MaxQBiQ8BG17
PaxDbiQ8BG17
PeptideAtlasiQ8BG17
PRIDEiQ8BG17

PTM databases

iPTMnetiQ8BG17
PhosphoSitePlusiQ8BG17

Expressioni

Tissue specificityi

Expressed in brain, lung, spleen, kidney and heart.1 Publication

Developmental stagei

Continuously expressed during embryogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000033099 Expressed in 273 organ(s), highest expression level in dorsal pancreas
CleanExiMM_NOL12
ExpressionAtlasiQ8BG17 baseline and differential
GenevisibleiQ8BG17 MM

Interactioni

Subunit structurei

Interacts with KIAA1191.By similarity

Protein-protein interaction databases

BioGridi220934, 1 interactor
IntActiQ8BG17, 1 interactor
STRINGi10090.ENSMUSP00000116103

Structurei

3D structure databases

ProteinModelPortaliQ8BG17
SMRiQ8BG17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 98Sequence analysisAdd BLAST65

Sequence similaritiesi

Belongs to the RRP17 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4709 Eukaryota
ENOG410XZ47 LUCA
GeneTreeiENSGT00390000015973
HOVERGENiHBG082042
InParanoidiQ8BG17
KOiK14851
OMAiSMEKPTK
OrthoDBiEOG091G0N95
PhylomeDBiQ8BG17
TreeFamiTF323855

Family and domain databases

InterProiView protein in InterPro
IPR019186 Nucleolar_protein_12
PANTHERiPTHR14577 PTHR14577, 1 hit
PfamiView protein in Pfam
PF09805 Nop25, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BG17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRNKKKKKR DGDDRRPRLV LNFDEEKRRE YLTGFHKRKV ERKKAAIEEI
60 70 80 90 100
KQRLKQEQKK LREERHQEYL KMLAEREEAL EEADELERLV TAKTESVQYD
110 120 130 140 150
HPNHTVTVTT ISDLDLSGAR LLGLPLPEQG DQDGSQEEEM SSLEKPTKAL
160 170 180 190 200
PRKSKDPLLS QRISSLTATL HAHSRKKVKR KHPRRAQDST KKPPSATRTS
210
KTQRRRRMTG KARHNGE
Length:217
Mass (Da):25,356
Last modified:March 1, 2003 - v1
Checksum:iD2CB0564FE6490A7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZCM5B7ZCM5_MOUSE
Nucleolar protein 12
Nol12
83Annotation score:
F8WGP0F8WGP0_MOUSE
Nucleolar protein 12
Nol12
195Annotation score:
B7ZBY4B7ZBY4_MOUSE
Nucleolar protein 12
Nol12
15Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29R → P in AAH13701 (PubMed:15489334).Curated1
Sequence conflicti92A → V in AAH13701 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY940114 mRNA Translation: AAX32893.1
AK037035 mRNA Translation: BAC29680.1
AK083539 mRNA Translation: BAC38946.1
AK167446 mRNA Translation: BAE39532.1
BC013701 mRNA Translation: AAH13701.1
BC094424 mRNA Translation: AAH94424.1
CCDSiCCDS27629.1
RefSeqiNP_598561.2, NM_133800.3
UniGeneiMm.157216

Genome annotation databases

EnsembliENSMUST00000138880; ENSMUSP00000116103; ENSMUSG00000033099
GeneIDi97961
KEGGimmu:97961
UCSCiuc007wrw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY940114 mRNA Translation: AAX32893.1
AK037035 mRNA Translation: BAC29680.1
AK083539 mRNA Translation: BAC38946.1
AK167446 mRNA Translation: BAE39532.1
BC013701 mRNA Translation: AAH13701.1
BC094424 mRNA Translation: AAH94424.1
CCDSiCCDS27629.1
RefSeqiNP_598561.2, NM_133800.3
UniGeneiMm.157216

3D structure databases

ProteinModelPortaliQ8BG17
SMRiQ8BG17
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220934, 1 interactor
IntActiQ8BG17, 1 interactor
STRINGi10090.ENSMUSP00000116103

PTM databases

iPTMnetiQ8BG17
PhosphoSitePlusiQ8BG17

Proteomic databases

EPDiQ8BG17
MaxQBiQ8BG17
PaxDbiQ8BG17
PeptideAtlasiQ8BG17
PRIDEiQ8BG17

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000138880; ENSMUSP00000116103; ENSMUSG00000033099
GeneIDi97961
KEGGimmu:97961
UCSCiuc007wrw.1 mouse

Organism-specific databases

CTDi79159
MGIiMGI:2146285 Nol12

Phylogenomic databases

eggNOGiKOG4709 Eukaryota
ENOG410XZ47 LUCA
GeneTreeiENSGT00390000015973
HOVERGENiHBG082042
InParanoidiQ8BG17
KOiK14851
OMAiSMEKPTK
OrthoDBiEOG091G0N95
PhylomeDBiQ8BG17
TreeFamiTF323855

Miscellaneous databases

PROiPR:Q8BG17
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033099 Expressed in 273 organ(s), highest expression level in dorsal pancreas
CleanExiMM_NOL12
ExpressionAtlasiQ8BG17 baseline and differential
GenevisibleiQ8BG17 MM

Family and domain databases

InterProiView protein in InterPro
IPR019186 Nucleolar_protein_12
PANTHERiPTHR14577 PTHR14577, 1 hit
PfamiView protein in Pfam
PF09805 Nop25, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOL12_MOUSE
AccessioniPrimary (citable) accession number: Q8BG17
Secondary accession number(s): Q91VI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again