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Protein

Transmembrane protein 184B

Gene

Tmem184b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May activate the MAP kinase signaling pathway.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 184B
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2445179 Tmem184b

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115561 – 407Transmembrane protein 184BAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei388PhosphoserineBy similarity1
Modified residuei402PhosphoserineBy similarity1
Modified residuei403PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BG09
PeptideAtlasiQ8BG09
PRIDEiQ8BG09

PTM databases

iPTMnetiQ8BG09
PhosphoSitePlusiQ8BG09
SwissPalmiQ8BG09

Expressioni

Gene expression databases

BgeeiENSMUSG00000009035 Expressed in 252 organ(s), highest expression level in dorsal pancreas
CleanExiMM_TMEM184B
GenevisibleiQ8BG09 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074518

Structurei

3D structure databases

ProteinModelPortaliQ8BG09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 19Poly-Thr4

Sequence similaritiesi

Belongs to the TMEM184 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2641 Eukaryota
ENOG410XQ3V LUCA
GeneTreeiENSGT00530000063204
HOGENOMiHOG000116663
HOVERGENiHBG051270
InParanoidiQ8BG09
OMAiKDIMQDA
OrthoDBiEOG091G07BZ
PhylomeDBiQ8BG09
TreeFamiTF314160

Family and domain databases

InterProiView protein in InterPro
IPR005178 Ostalpha/TMEM184C
PANTHERiPTHR23423 PTHR23423, 1 hit
PfamiView protein in Pfam
PF03619 Solute_trans_a, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8BG09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVRGAALAP DPASPTTTTA SPSVSATPEG SPTAMEHPVF LMTTAAQAIS
60 70 80 90 100
GFFVWTALLI TCHQIYMHLR CYSRPNEQRH IVRILFIVPI YAFDSWLSLL
110 120 130 140 150
FFTNDQYYVY FGTVRDCYEA FVIYNFLSLC YEYLGGESAI MSEIRGKAIE
160 170 180 190 200
SSCMYGTCCL WGKTYSIGFL RFCKQATLQF CVVKPLMAVS TVILQAFGKY
210 220 230 240 250
RDGDFDVTSG YLYVTIIYNI SVSLALYALF LFYFATRELL SPYSPVLKFF
260 270 280 290 300
MVKSVIFLSF WQGMLLAILE KCGAIPKINS ARVSVGEGTV AAGYQDFIIC
310 320 330 340 350
VEMFFAALAL RHAFTYKVYA DKRLDAQGRC APMKSISSSL KETMNPHDIV
360 370 380 390 400
QDAIHNFSPA YQQYTQQSTL EPGPTWRGGT HSLSRSHSLS GARDNEKTLL

LSSDDEF
Length:407
Mass (Da):45,589
Last modified:March 1, 2003 - v1
Checksum:iD708E141A34DEC73
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQI5A0A2I3BQI5_MOUSE
Transmembrane protein 184B
Tmem184b
414Annotation score:
A0A2I3BQ63A0A2I3BQ63_MOUSE
Transmembrane protein 184B
Tmem184b
120Annotation score:
A0A2R8VI00A0A2R8VI00_MOUSE
Transmembrane protein 184B
Tmem184b
222Annotation score:
A0A2R8W6P8A0A2R8W6P8_MOUSE
Transmembrane protein 184B
Tmem184b
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti327Q → QVLTYGPY in BAC33254 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028196 mRNA Translation: BAC25805.1
AK029129 mRNA Translation: BAC26312.1
AK048138 mRNA Translation: BAC33254.1
AK149366 mRNA Translation: BAE28837.1
AK158789 mRNA Translation: BAE34666.1
AK170086 mRNA Translation: BAE41556.1
BC046959 mRNA Translation: AAH46959.1
CCDSiCCDS27639.1
RefSeqiNP_001240746.1, NM_001253817.1
NP_001240748.1, NM_001253819.1
NP_001240749.1, NM_001253820.1
NP_766196.1, NM_172608.1
UniGeneiMm.323358

Genome annotation databases

EnsembliENSMUST00000074991; ENSMUSP00000074518; ENSMUSG00000009035
ENSMUST00000178522; ENSMUSP00000136416; ENSMUSG00000009035
GeneIDi223693
KEGGimmu:223693
UCSCiuc007wti.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028196 mRNA Translation: BAC25805.1
AK029129 mRNA Translation: BAC26312.1
AK048138 mRNA Translation: BAC33254.1
AK149366 mRNA Translation: BAE28837.1
AK158789 mRNA Translation: BAE34666.1
AK170086 mRNA Translation: BAE41556.1
BC046959 mRNA Translation: AAH46959.1
CCDSiCCDS27639.1
RefSeqiNP_001240746.1, NM_001253817.1
NP_001240748.1, NM_001253819.1
NP_001240749.1, NM_001253820.1
NP_766196.1, NM_172608.1
UniGeneiMm.323358

3D structure databases

ProteinModelPortaliQ8BG09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074518

PTM databases

iPTMnetiQ8BG09
PhosphoSitePlusiQ8BG09
SwissPalmiQ8BG09

Proteomic databases

PaxDbiQ8BG09
PeptideAtlasiQ8BG09
PRIDEiQ8BG09

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074991; ENSMUSP00000074518; ENSMUSG00000009035
ENSMUST00000178522; ENSMUSP00000136416; ENSMUSG00000009035
GeneIDi223693
KEGGimmu:223693
UCSCiuc007wti.1 mouse

Organism-specific databases

CTDi25829
MGIiMGI:2445179 Tmem184b

Phylogenomic databases

eggNOGiKOG2641 Eukaryota
ENOG410XQ3V LUCA
GeneTreeiENSGT00530000063204
HOGENOMiHOG000116663
HOVERGENiHBG051270
InParanoidiQ8BG09
OMAiKDIMQDA
OrthoDBiEOG091G07BZ
PhylomeDBiQ8BG09
TreeFamiTF314160

Miscellaneous databases

PROiPR:Q8BG09
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009035 Expressed in 252 organ(s), highest expression level in dorsal pancreas
CleanExiMM_TMEM184B
GenevisibleiQ8BG09 MM

Family and domain databases

InterProiView protein in InterPro
IPR005178 Ostalpha/TMEM184C
PANTHERiPTHR23423 PTHR23423, 1 hit
PfamiView protein in Pfam
PF03619 Solute_trans_a, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT184B_MOUSE
AccessioniPrimary (citable) accession number: Q8BG09
Secondary accession number(s): Q3TY97, Q8BJ02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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