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Entry version 137 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein

5'-3' exonuclease PLD4

Gene

Pld4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30111894).

Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor (PubMed:30111894).

Involved in phagocytosis of activated microglia (PubMed:22102906).

2 Publications

Caution

Exhibits no phospholipase activity, despite two HKD motifs.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is pH 5.5-5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei212PROSITE-ProRule annotation1
Active sitei214PROSITE-ProRule annotation1
Active sitei219PROSITE-ProRule annotation1
Active sitei426PROSITE-ProRule annotation1
Active sitei428PROSITE-ProRule annotation1
Active sitei433PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol
R-MMU-2029485, Role of phospholipids in phagocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-3' exonuclease PLD4Curated (EC:3.1.16.11 Publication)
Alternative name(s):
Choline phosphatase 4
Phosphatidylcholine-hydrolyzing phospholipase D4
Phospholipase D4
Short name:
PLD 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pld4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2144765, Pld4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000052160

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36Cytoplasmic1 PublicationAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57Signal-anchor for type II membrane proteinCuratedAdd BLAST21
Topological domaini58 – 503Lumenal1 PublicationAdd BLAST446

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice exhibit a phenotype of chronic activation of the immune system, with splenomegaly marked by elevated levels of interferon-gamma (IFN-gamma) (PubMed:30111894). PDL3 and PLD4 double-deficient mice are unable to survive beyond the age of 21 days due to severe liver inflammation (PubMed:30111894). Livers from double-knockout mice develop lethal hepatic autoinflammatory disease that could be prevented by a single allele of either PDL3 or PLD4 (PubMed:30111894).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002803341 – 5035'-3' exonuclease PLD4Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi148N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi169N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi247N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi279N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi415N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi425N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi442N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BG07

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BG07

PeptideAtlas

More...
PeptideAtlasi
Q8BG07

PRoteomics IDEntifications database

More...
PRIDEi
Q8BG07

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
289757 [Q8BG07-1]
289758 [Q8BG07-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2584, 4 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8BG07, 8 sites, 4 N-linked glycans (3 sites)

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BG07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Enriched in the white matter of early postnatal brains, as well as in splenic marginal zone cells (PubMed:21085684). Highly expressed in dendritic cells (DCs) and other myeloid cells, with lower expression in B cell (PubMed:30111894).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected in cerebellum at postnatal day 0 (P0), increased with age and peaked at P7, and then rapidly decreased to adult levels by P21.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by lipopolysaccharide (LPS) stimulation in microglia (PubMed:22102906). Increased expression in activated microglia and in the demyelinating lesions of adult brain (PubMed:22102906).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052160, Expressed in bone marrow macrophage and 178 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BG07, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
222698, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000067002

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BG07, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini207 – 234PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini421 – 447PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3603, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027021_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BG07

Identification of Orthologs from Complete Genome Data

More...
OMAi
KIRMLIS

Database of Orthologous Groups

More...
OrthoDBi
1057467at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BG07

TreeFam database of animal gene trees

More...
TreeFami
TF313378

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032803, PLDc_3
IPR001736, PLipase_D/transphosphatidylase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00614, PLDc, 2 hits
PF13918, PLDc_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00155, PLDc, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50035, PLD, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BG07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKKKEHPEM RIPLQTAVEV SDWPCSTSHD PHSGLGMVLG MLAVLGLSSV
60 70 80 90 100
TLILFLWQGA TSFTSHRMFP EEVPSWSWET LKGDAEQQNN SCQLILVESI
110 120 130 140 150
PEDLPFAAGS PTAQPLAQAW LQLLDTARES VHIASYYWSL TGLDIGVNDS
160 170 180 190 200
SSRQGEALLQ KFQQLLLRNI SVVVATHSPT LAKTSTDLQV LAAHGAQIRQ
210 220 230 240 250
VPMKQLTGGV LHSKFWVVDG RHIYVGSANM DWRSLTQVKE LGAIIYNCSN
260 270 280 290 300
LAQDLEKTFQ TYWVLGTPQA VLPKTWPRNF SSHINRFHPL RGPFDGVPTT
310 320 330 340 350
AYFSASPPSL CPHGRTRDLD AVLGVMEGAR QFIYVSVMEY FPTTRFTHHA
360 370 380 390 400
RYWPVLDNAL RAAALNKGVH VRLLVSCWFN TDPTMFAYLR SLQAFSNPSA
410 420 430 440 450
GISVDVKVFI VPVGNHSNIP FSRVNHSKFM VTDKTAYVGT SNWSEDYFSH
460 470 480 490 500
TAGVGLIVSQ KTPRAQPGAT TVQEQLRQLF ERDWSSHYAM DLDRQVPSQD

CVW
Length:503
Mass (Da):56,154
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD72EB7DEBAC9598F
GO
Isoform 2 (identifier: Q8BG07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MDKKKEHPE → M

Show »
Length:495
Mass (Da):55,162
Checksum:iA0FCEEDA73B5BAED
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC32379 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti223I → V in AAH58565 (PubMed:15489334).Curated1
Sequence conflicti294F → L in BAE41745 (PubMed:16141072).Curated1
Sequence conflicti450H → Y in BAE41745 (PubMed:16141072).Curated1
Sequence conflicti452A → G in BAC32379 (PubMed:16141072).Curated1
Sequence conflicti455G → V in BAC32379 (PubMed:16141072).Curated1
Sequence conflicti483D → G in BAC32379 (PubMed:16141072).Curated1
Sequence conflicti489A → G in BAC32379 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0236301 – 9MDKKKEHPE → M in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK045459 mRNA Translation: BAC32379.1 Frameshift.
AK079549 mRNA Translation: BAC37681.1
AK079878 mRNA Translation: BAC37771.1
AK151551 mRNA Translation: BAE30496.1
AK170362 mRNA Translation: BAE41745.1
BC058565 mRNA Translation: AAH58565.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26195.1 [Q8BG07-1]

NCBI Reference Sequences

More...
RefSeqi
NP_849242.1, NM_178911.4 [Q8BG07-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000063888; ENSMUSP00000067002; ENSMUSG00000052160 [Q8BG07-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
104759

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:104759

UCSC genome browser

More...
UCSCi
uc007pfc.1, mouse [Q8BG07-1]
uc007pfd.1, mouse [Q8BG07-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045459 mRNA Translation: BAC32379.1 Frameshift.
AK079549 mRNA Translation: BAC37681.1
AK079878 mRNA Translation: BAC37771.1
AK151551 mRNA Translation: BAE30496.1
AK170362 mRNA Translation: BAE41745.1
BC058565 mRNA Translation: AAH58565.1
CCDSiCCDS26195.1 [Q8BG07-1]
RefSeqiNP_849242.1, NM_178911.4 [Q8BG07-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi222698, 1 interactor
STRINGi10090.ENSMUSP00000067002

PTM databases

GlyConnecti2584, 4 N-Linked glycans (3 sites)
GlyGeniQ8BG07, 8 sites, 4 N-linked glycans (3 sites)
PhosphoSitePlusiQ8BG07

Proteomic databases

jPOSTiQ8BG07
PaxDbiQ8BG07
PeptideAtlasiQ8BG07
PRIDEiQ8BG07
ProteomicsDBi289757 [Q8BG07-1]
289758 [Q8BG07-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28277, 191 antibodies

Genome annotation databases

EnsembliENSMUST00000063888; ENSMUSP00000067002; ENSMUSG00000052160 [Q8BG07-1]
GeneIDi104759
KEGGimmu:104759
UCSCiuc007pfc.1, mouse [Q8BG07-1]
uc007pfd.1, mouse [Q8BG07-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
122618
MGIiMGI:2144765, Pld4
VEuPathDBiHostDB:ENSMUSG00000052160

Phylogenomic databases

eggNOGiKOG3603, Eukaryota
GeneTreeiENSGT00950000183059
HOGENOMiCLU_027021_0_0_1
InParanoidiQ8BG07
OMAiKIRMLIS
OrthoDBi1057467at2759
PhylomeDBiQ8BG07
TreeFamiTF313378

Enzyme and pathway databases

ReactomeiR-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol
R-MMU-2029485, Role of phospholipids in phagocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
104759, 2 hits in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pld4, mouse

Protein Ontology

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PROi
PR:Q8BG07
RNActiQ8BG07, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000052160, Expressed in bone marrow macrophage and 178 other tissues
GenevisibleiQ8BG07, MM

Family and domain databases

InterProiView protein in InterPro
IPR032803, PLDc_3
IPR001736, PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF00614, PLDc, 2 hits
PF13918, PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155, PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035, PLD, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLD4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BG07
Secondary accession number(s): Q3TD59
, Q3UA19, Q6PDR0, Q8BR69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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