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Protein

Heterogeneous nuclear ribonucleoprotein A3

Gene

Hnrnpa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A3
Short name:
hnRNP A3
Gene namesi
Name:Hnrnpa3
Synonyms:Hnrpa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1917171 Hnrnpa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818391 – 379Heterogeneous nuclear ribonucleoprotein A3Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei14PhosphoserineBy similarity1
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei43PhosphoserineBy similarity1
Modified residuei52Dimethylated arginine; alternateBy similarity1
Modified residuei52Omega-N-methylarginine; alternateBy similarity1
Modified residuei76Omega-N-methylarginineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei124PhosphothreonineBy similarity1
Modified residuei134N6-acetyllysine; alternateBy similarity1
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei214Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei214Omega-N-methylarginine; alternateBy similarity1
Modified residuei216Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei216Omega-N-methylarginine; alternateBy similarity1
Modified residuei226Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei226Omega-N-methylarginine; alternateCombined sources1
Modified residuei239Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei239Omega-N-methylarginine; alternateCombined sources1
Modified residuei246Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei246Omega-N-methylarginine; alternateCombined sources1
Modified residuei257Omega-N-methylarginineCombined sources1
Modified residuei286Asymmetric dimethylarginineBy similarity1
Modified residuei351PhosphoserineBy similarity1
Modified residuei355Omega-N-methylarginineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei361PhosphotyrosineBy similarity1
Modified residuei365PhosphotyrosineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei371PhosphoserineBy similarity1
Modified residuei374PhosphotyrosineBy similarity1
Modified residuei376PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BG05
PaxDbiQ8BG05
PRIDEiQ8BG05
TopDownProteomicsiQ8BG05-1 [Q8BG05-1]

2D gel databases

REPRODUCTION-2DPAGEiQ8BG05

PTM databases

iPTMnetiQ8BG05
PhosphoSitePlusiQ8BG05
SwissPalmiQ8BG05

Expressioni

Gene expression databases

BgeeiENSMUSG00000059005
ExpressionAtlasiQ8BG05 baseline and differential
GenevisibleiQ8BG05 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

BioGridi230827, 35 interactors
IntActiQ8BG05, 34 interactors
MINTiQ8BG05
STRINGi10090.ENSMUSP00000088298

Structurei

3D structure databases

ProteinModelPortaliQ8BG05
SMRiQ8BG05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 118RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini126 – 205RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 379Gly-richAdd BLAST169

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
HOGENOMiHOG000234442
HOVERGENiHBG002295
InParanoidiQ8BG05
KOiK12741
OMAiYYDSTGY
OrthoDBiEOG091G1CPI
TreeFamiTF314808

Family and domain databases

CDDicd12763 RRM1_hnRNPA3, 1 hit
cd12582 RRM2_hnRNPA3, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034513 hnRNPA3_RRM1
IPR034516 hnRNPA3_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BG05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS
60 70 80 90 100
LREHFEKWGT LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV
110 120 130 140 150
DGRVVEPKRA VSREDSVKPG AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG
160 170 180 190 200
KIETIEVMED RQSGKKRGFA FVTFDDHDTV DKIVVQKYHT INGHNCEVKK
210 220 230 240 250
ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG GNFGGRGGYG
260 270 280 290 300
GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
310 320 330 340 350
GGYGGGGGGY DGYNEGGNFG GGNYGGGGNY NDFGNYSGQQ QSNYGPMKGG
360 370
SFGGRSSGSP YGGGYGSGGG SGGYGSRRF
Length:379
Mass (Da):39,652
Last modified:March 1, 2003 - v1
Checksum:iD83C400A2B096E9B
GO
Isoform 2 (identifier: Q8BG05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEVKPPPGRPQPDSGRRRRRRGE → M

Show »
Length:357
Mass (Da):37,086
Checksum:i222DBB3DF00D2D7A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0073501 – 23MEVKP…RRRGE → M in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF463524 mRNA Translation: AAN76992.1
BC023828 mRNA Translation: AAH23828.1
BC023908 mRNA Translation: AAH23908.1
BC038364 mRNA Translation: AAH38364.1
BC064824 mRNA Translation: AAH64824.1
CCDSiCCDS16149.1 [Q8BG05-1]
CCDS50610.1 [Q8BG05-2]
RefSeqiNP_444493.1, NM_053263.1 [Q8BG05-2]
NP_666242.2, NM_146130.3 [Q8BG05-1]
NP_932758.1, NM_198090.2 [Q8BG05-1]
XP_011237818.1, XM_011239516.2
UniGeneiMm.316306
Mm.331491
Mm.379375

Genome annotation databases

EnsembliENSMUST00000090792; ENSMUSP00000088298; ENSMUSG00000059005 [Q8BG05-1]
ENSMUST00000111962; ENSMUSP00000107593; ENSMUSG00000059005 [Q8BG05-2]
ENSMUST00000111964; ENSMUSP00000107595; ENSMUSG00000059005 [Q8BG05-1]
ENSMUST00000164947; ENSMUSP00000126069; ENSMUSG00000059005 [Q8BG05-2]
GeneIDi229279
KEGGimmu:229279
UCSCiuc008ken.2 mouse [Q8BG05-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiROA3_MOUSE
AccessioniPrimary (citable) accession number: Q8BG05
Secondary accession number(s): Q8BHF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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