UniProtKB - Q8BFZ2 (PLPR1_MOUSE)
Protein
Phospholipid phosphatase-related protein type 1
Gene
Plppr1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- lipid phosphatase activity Source: GO_Central
- phosphatase activity Source: GO_Central
- phosphatidate phosphatase activity Source: GO_Central
GO - Biological processi
- nervous system development Source: MGI
- phospholipid dephosphorylation Source: GO_Central
- phospholipid metabolic process Source: GO_Central
- signal transduction Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid phosphatase-related protein type 1By similarityAlternative name(s): Lipid phosphate phosphatase-related protein type 1By similarity Plasticity-related gene 3 protein1 Publication Short name: PRG-31 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2445015, Plppr1 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 33 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 218 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 230 – 247 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 257 – 277 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317533 | 1 – 325 | Phospholipid phosphatase-related protein type 1Add BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 316 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q8BFZ2 |
PRIDEi | Q8BFZ2 |
PTM databases
GlyGeni | Q8BFZ2, 3 sites |
iPTMneti | Q8BFZ2 |
PhosphoSitePlusi | Q8BFZ2 |
SwissPalmi | Q8BFZ2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000063446, Expressed in cerebral cortex and 90 other tissues |
Genevisiblei | Q8BFZ2, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000075966 |
Miscellaneous databases
RNActi | Q8BFZ2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the PA-phosphatase related phosphoesterase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3030, Eukaryota |
GeneTreei | ENSGT00940000158875 |
HOGENOMi | CLU_021458_1_0_1 |
InParanoidi | Q8BFZ2 |
OMAi | YITSTIR |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q8BFZ2 |
TreeFami | TF316040 |
Family and domain databases
InterProi | View protein in InterPro IPR028678, LPPR1 IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PLPP |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF41, PTHR10165:SF41, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8BFZ2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVENNTQRS YSIIPCFIFV ELVIMAGTVL LAYYFECTDT FQVHIQGFFC
60 70 80 90 100
QDGDLMKPYP GTEEESFISP LVLYCVLAAT PTAIIFIGEI SMYFIKSTRE
110 120 130 140 150
SLIAEEKMIL TGDCCYLSPL LRRIIRFIGV FAFGLFATDI FVNAGQVVTG
160 170 180 190 200
HLTPYFLTVC QPNYTSTDCR AHQQFINNGN ICTGDLEVIE KARRSFPSKH
210 220 230 240 250
AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCTAF LTGLNRVSEY
260 270 280 290 300
RNHCSDVIAG FILGTAVALF LGMCVVHNFR GTQGSPSKPK PEDPRGVPLM
310 320
AFPRIESPLE TLSAQNHSAS MTEVT
Sequence cautioni
The sequence BAD90332 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | P → L in AAH96762 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 190 | E → G in BAC39874 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031009 | 129 – 158 | Missing in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY345342 mRNA Translation: AAR09144.1 AK220568 mRNA Translation: BAD90332.1 Different initiation. AK034251 mRNA Translation: BAC28649.1 AK043762 mRNA Translation: BAC31647.1 AK047614 mRNA Translation: BAC33101.1 AK087439 mRNA Translation: BAC39874.1 AK087514 mRNA Translation: BAC39907.1 AK160897 mRNA Translation: BAE36076.1 AL808138 Genomic DNA No translation available. AL928612 Genomic DNA No translation available. BX537352 Genomic DNA No translation available. BC096762 mRNA Translation: AAH96762.1 |
CCDSi | CCDS18170.1 [Q8BFZ2-1] |
RefSeqi | NP_848871.1, NM_178756.4 [Q8BFZ2-1] XP_006538031.1, XM_006537968.3 [Q8BFZ2-1] XP_011248351.1, XM_011250049.2 [Q8BFZ2-1] XP_017175739.1, XM_017320250.1 [Q8BFZ2-1] |
Genome annotation databases
Ensembli | ENSMUST00000076670; ENSMUSP00000075966; ENSMUSG00000063446 [Q8BFZ2-1] |
GeneIDi | 272031 |
KEGGi | mmu:272031 |
UCSCi | uc008svp.1, mouse [Q8BFZ2-1] uc012dea.1, mouse [Q8BFZ2-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY345342 mRNA Translation: AAR09144.1 AK220568 mRNA Translation: BAD90332.1 Different initiation. AK034251 mRNA Translation: BAC28649.1 AK043762 mRNA Translation: BAC31647.1 AK047614 mRNA Translation: BAC33101.1 AK087439 mRNA Translation: BAC39874.1 AK087514 mRNA Translation: BAC39907.1 AK160897 mRNA Translation: BAE36076.1 AL808138 Genomic DNA No translation available. AL928612 Genomic DNA No translation available. BX537352 Genomic DNA No translation available. BC096762 mRNA Translation: AAH96762.1 |
CCDSi | CCDS18170.1 [Q8BFZ2-1] |
RefSeqi | NP_848871.1, NM_178756.4 [Q8BFZ2-1] XP_006538031.1, XM_006537968.3 [Q8BFZ2-1] XP_011248351.1, XM_011250049.2 [Q8BFZ2-1] XP_017175739.1, XM_017320250.1 [Q8BFZ2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000075966 |
PTM databases
GlyGeni | Q8BFZ2, 3 sites |
iPTMneti | Q8BFZ2 |
PhosphoSitePlusi | Q8BFZ2 |
SwissPalmi | Q8BFZ2 |
Proteomic databases
PaxDbi | Q8BFZ2 |
PRIDEi | Q8BFZ2 |
Protocols and materials databases
Antibodypediai | 14633, 37 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000076670; ENSMUSP00000075966; ENSMUSG00000063446 [Q8BFZ2-1] |
GeneIDi | 272031 |
KEGGi | mmu:272031 |
UCSCi | uc008svp.1, mouse [Q8BFZ2-1] uc012dea.1, mouse [Q8BFZ2-2] |
Organism-specific databases
CTDi | 54886 |
MGIi | MGI:2445015, Plppr1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3030, Eukaryota |
GeneTreei | ENSGT00940000158875 |
HOGENOMi | CLU_021458_1_0_1 |
InParanoidi | Q8BFZ2 |
OMAi | YITSTIR |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q8BFZ2 |
TreeFami | TF316040 |
Miscellaneous databases
BioGRID-ORCSi | 272031, 1 hit in 17 CRISPR screens |
ChiTaRSi | Plppr1, mouse |
PROi | PR:Q8BFZ2 |
RNActi | Q8BFZ2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063446, Expressed in cerebral cortex and 90 other tissues |
Genevisiblei | Q8BFZ2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR028678, LPPR1 IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PLPP |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF41, PTHR10165:SF41, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLPR1_MOUSE | |
Accessioni | Q8BFZ2Primary (citable) accession number: Q8BFZ2 Secondary accession number(s): Q4V9R3 Q8BIQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families