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Protein

PCI domain-containing protein 2

Gene

Pcid2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (PubMed:20870947). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.By similarity1 Publication

GO - Molecular functioni

  • double-stranded DNA binding Source: GO_Central
  • RNA binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PCI domain-containing protein 2
Alternative name(s):
CSN12-like protein
Gene namesi
Name:Pcid2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443003 Pcid2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210302 – 399PCI domain-containing protein 2Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BFV2
MaxQBiQ8BFV2
PaxDbiQ8BFV2
PRIDEiQ8BFV2

PTM databases

iPTMnetiQ8BFV2
PhosphoSitePlusiQ8BFV2

Expressioni

Developmental stagei

In B lineage cells, expressed in a stage-dependent manner at high levels in bone marrow pre-B and immature B-cells, and in spleen transitional 1 and follicular B-cells, but at lower levels in pro-B, transitional 2, and marginal zone B-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000038542 Expressed in 291 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_PCID2
ExpressionAtlasiQ8BFV2 baseline and differential
GenevisibleiQ8BFV2 MM

Interactioni

Subunit structurei

Belongs to the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. Interacts with BRCA2.By similarity

Protein-protein interaction databases

BioGridi231489, 2 interactors
IntActiQ8BFV2, 1 interactor
STRINGi10090.ENSMUSP00000133204

Structurei

3D structure databases

ProteinModelPortaliQ8BFV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 391PCIPROSITE-ProRule annotationAdd BLAST182

Sequence similaritiesi

Belongs to the CSN12 family.Curated

Phylogenomic databases

eggNOGiKOG2688 Eukaryota
COG5600 LUCA
GeneTreeiENSGT00390000001101
HOVERGENiHBG055800
InParanoidiQ8BFV2
OMAiSRKWGIY
OrthoDBiEOG091G09MD
PhylomeDBiQ8BFV2
TreeFamiTF106136

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BFV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHITINQYL QQVYEAIDTR DGASCAELVS FKHPHVANPR LQMASPEEKC
60 70 80 90 100
QQVLEPPYDE MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE
110 120 130 140 150
ENWALPVMYA VALDLRIFAN NADQQLVKKG KSKVGDMLEK AAELLMSCFR
160 170 180 190 200
VCASDTRAGI EDSKKWGMLF LVNQLFKIYF KINKLHLCKP LIRAIDSSNL
210 220 230 240 250
KDDYSTAQRI TYKYYVGRKA MFDSDFKQAE EYLSFAFEHC HRSSQKNKRM
260 270 280 290 300
ILIYLLPVKM LLGHMPTIEL LRKYHLMQFS EVTKAVSEGN LLLLNEALAK
310 320 330 340 350
HETFFIRCGI FLILEKLKII TYRNLFKKVY LLLKTHQLSL DAFLVALKFM
360 370 380 390
HVEDVDIDEV QCILANLIYM GHIKGYISHQ HQKLVVSKQN PFPPLSTVC
Length:399
Mass (Da):46,132
Last modified:March 1, 2003 - v1
Checksum:iEA4B7DC9891D59F7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q1H5E9Q1H5_MOUSE
PCI domain-containing protein 2
Pcid2
128Annotation score:
E9Q5V9E9Q5V9_MOUSE
PCI domain-containing protein 2
Pcid2
52Annotation score:
F6QZZ3F6QZZ3_MOUSE
PCI domain-containing protein 2
Pcid2
23Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227K → N in BAC31414 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045796 mRNA Translation: BAC32494.1
AK042945 mRNA Translation: BAC31414.1
AK048722 mRNA Translation: BAC33434.1
AK163697 mRNA Translation: BAE37463.1
BC118533 mRNA Translation: AAI18534.1
CCDSiCCDS52484.1
RefSeqiNP_848823.2, NM_178708.3
UniGeneiMm.103427

Genome annotation databases

EnsembliENSMUST00000164416; ENSMUSP00000133204; ENSMUSG00000038542
GeneIDi234069
KEGGimmu:234069
UCSCiuc012fzt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045796 mRNA Translation: BAC32494.1
AK042945 mRNA Translation: BAC31414.1
AK048722 mRNA Translation: BAC33434.1
AK163697 mRNA Translation: BAE37463.1
BC118533 mRNA Translation: AAI18534.1
CCDSiCCDS52484.1
RefSeqiNP_848823.2, NM_178708.3
UniGeneiMm.103427

3D structure databases

ProteinModelPortaliQ8BFV2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231489, 2 interactors
IntActiQ8BFV2, 1 interactor
STRINGi10090.ENSMUSP00000133204

PTM databases

iPTMnetiQ8BFV2
PhosphoSitePlusiQ8BFV2

Proteomic databases

EPDiQ8BFV2
MaxQBiQ8BFV2
PaxDbiQ8BFV2
PRIDEiQ8BFV2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164416; ENSMUSP00000133204; ENSMUSG00000038542
GeneIDi234069
KEGGimmu:234069
UCSCiuc012fzt.1 mouse

Organism-specific databases

CTDi55795
MGIiMGI:2443003 Pcid2

Phylogenomic databases

eggNOGiKOG2688 Eukaryota
COG5600 LUCA
GeneTreeiENSGT00390000001101
HOVERGENiHBG055800
InParanoidiQ8BFV2
OMAiSRKWGIY
OrthoDBiEOG091G09MD
PhylomeDBiQ8BFV2
TreeFamiTF106136

Miscellaneous databases

PROiPR:Q8BFV2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038542 Expressed in 291 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_PCID2
ExpressionAtlasiQ8BFV2 baseline and differential
GenevisibleiQ8BFV2 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCID2_MOUSE
AccessioniPrimary (citable) accession number: Q8BFV2
Secondary accession number(s): Q147Z6, Q8C951
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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