UniProtKB - Q8BFV2 (PCID2_MOUSE)
PCI domain-containing protein 2
Pcid2
Functioni
GO - Molecular functioni
- double-stranded DNA binding Source: GO_Central
- RNA binding Source: GO_Central
GO - Biological processi
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity Source: MGI
- nuclear retention of pre-mRNA at the site of transcription Source: GO_Central
- poly(A)+ mRNA export from nucleus Source: GO_Central
- positive regulation of B cell differentiation Source: UniProtKB
- positive regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: GO_Central
- regulation of mRNA stability Source: UniProtKB
- spleen development Source: UniProtKB
- transcription elongation from RNA polymerase II promoter Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: PCI domain-containing protein 2Alternative name(s): CSN12-like protein |
Gene namesi | Name:Pcid2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443003, Pcid2 |
Subcellular locationi
Nucleus
- nuclear pore nuclear basket Source: UniProtKB
- nucleus Source: UniProtKB
- transcription export complex 2 Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000121030 | 2 – 399 | PCI domain-containing protein 2Add BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 45 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8BFV2 |
MaxQBi | Q8BFV2 |
PaxDbi | Q8BFV2 |
PRIDEi | Q8BFV2 |
PTM databases
iPTMneti | Q8BFV2 |
PhosphoSitePlusi | Q8BFV2 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000038542, Expressed in tracheobronchial tree and 307 other tissues |
ExpressionAtlasi | Q8BFV2, baseline and differential |
Genevisiblei | Q8BFV2, MM |
Interactioni
Subunit structurei
Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (By similarity).
Interacts with BRCA2 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 231489, 7 interactors |
IntActi | Q8BFV2, 1 interactor |
STRINGi | 10090.ENSMUSP00000133204 |
Miscellaneous databases
RNActi | Q8BFV2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 391 | PCIPROSITE-ProRule annotationAdd BLAST | 182 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2688, Eukaryota |
GeneTreei | ENSGT00390000001101 |
HOGENOMi | CLU_031567_2_0_1 |
InParanoidi | Q8BFV2 |
OMAi | TYLIPCH |
OrthoDBi | 706700at2759 |
PhylomeDBi | Q8BFV2 |
TreeFami | TF106136 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000717, PCI_dom IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAHITINQYL QQVYEAIDTR DGASCAELVS FKHPHVANPR LQMASPEEKC
60 70 80 90 100
QQVLEPPYDE MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE
110 120 130 140 150
ENWALPVMYA VALDLRIFAN NADQQLVKKG KSKVGDMLEK AAELLMSCFR
160 170 180 190 200
VCASDTRAGI EDSKKWGMLF LVNQLFKIYF KINKLHLCKP LIRAIDSSNL
210 220 230 240 250
KDDYSTAQRI TYKYYVGRKA MFDSDFKQAE EYLSFAFEHC HRSSQKNKRM
260 270 280 290 300
ILIYLLPVKM LLGHMPTIEL LRKYHLMQFS EVTKAVSEGN LLLLNEALAK
310 320 330 340 350
HETFFIRCGI FLILEKLKII TYRNLFKKVY LLLKTHQLSL DAFLVALKFM
360 370 380 390
HVEDVDIDEV QCILANLIYM GHIKGYISHQ HQKLVVSKQN PFPPLSTVC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q1H5 | E9Q1H5_MOUSE | PCI domain-containing protein 2 | Pcid2 | 128 | Annotation score: | ||
E9Q5V9 | E9Q5V9_MOUSE | PCI domain-containing protein 2 | Pcid2 | 52 | Annotation score: | ||
F6QZZ3 | F6QZZ3_MOUSE | PCI domain-containing protein 2 | Pcid2 | 23 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 227 | K → N in BAC31414 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045796 mRNA Translation: BAC32494.1 AK042945 mRNA Translation: BAC31414.1 AK048722 mRNA Translation: BAC33434.1 AK163697 mRNA Translation: BAE37463.1 BC118533 mRNA Translation: AAI18534.1 |
CCDSi | CCDS52484.1 |
RefSeqi | NP_848823.2, NM_178708.3 |
Genome annotation databases
Ensembli | ENSMUST00000164416; ENSMUSP00000133204; ENSMUSG00000038542 |
GeneIDi | 234069 |
KEGGi | mmu:234069 |
UCSCi | uc012fzt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045796 mRNA Translation: BAC32494.1 AK042945 mRNA Translation: BAC31414.1 AK048722 mRNA Translation: BAC33434.1 AK163697 mRNA Translation: BAE37463.1 BC118533 mRNA Translation: AAI18534.1 |
CCDSi | CCDS52484.1 |
RefSeqi | NP_848823.2, NM_178708.3 |
3D structure databases
SMRi | Q8BFV2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231489, 7 interactors |
IntActi | Q8BFV2, 1 interactor |
STRINGi | 10090.ENSMUSP00000133204 |
PTM databases
iPTMneti | Q8BFV2 |
PhosphoSitePlusi | Q8BFV2 |
Proteomic databases
EPDi | Q8BFV2 |
MaxQBi | Q8BFV2 |
PaxDbi | Q8BFV2 |
PRIDEi | Q8BFV2 |
Protocols and materials databases
Antibodypediai | 25858, 88 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000164416; ENSMUSP00000133204; ENSMUSG00000038542 |
GeneIDi | 234069 |
KEGGi | mmu:234069 |
UCSCi | uc012fzt.1, mouse |
Organism-specific databases
CTDi | 55795 |
MGIi | MGI:2443003, Pcid2 |
Phylogenomic databases
eggNOGi | KOG2688, Eukaryota |
GeneTreei | ENSGT00390000001101 |
HOGENOMi | CLU_031567_2_0_1 |
InParanoidi | Q8BFV2 |
OMAi | TYLIPCH |
OrthoDBi | 706700at2759 |
PhylomeDBi | Q8BFV2 |
TreeFami | TF106136 |
Miscellaneous databases
BioGRID-ORCSi | 234069, 7 hits in 17 CRISPR screens |
ChiTaRSi | Pcid2, mouse |
PROi | PR:Q8BFV2 |
RNActi | Q8BFV2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038542, Expressed in tracheobronchial tree and 307 other tissues |
ExpressionAtlasi | Q8BFV2, baseline and differential |
Genevisiblei | Q8BFV2, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000717, PCI_dom IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCID2_MOUSE | |
Accessioni | Q8BFV2Primary (citable) accession number: Q8BFV2 Secondary accession number(s): Q147Z6, Q8C951 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | August 12, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families