UniProtKB - Q8BFV2 (PCID2_MOUSE)

BLAST

>sp|Q8BFV2|PCID2_MOUSE PCI domain-containing protein 2 OS=Mus musculus OX=10090 GN=Pcid2 PE=1 SV=1
MAHITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDE
MFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFAN
NADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYF
KINKLHLCKPLIRAIDSSNLKDDYSTAQRITYKYYVGRKAMFDSDFKQAEEYLSFAFEHC
HRSSQKNKRMILIYLLPVKMLLGHMPTIELLRKYHLMQFSEVTKAVSEGNLLLLNEALAK
HETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMHVEDVDIDEV
QCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSTVC

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History
Entry version 100 (07 Nov 2018)
Sequence version 1 (01 Mar 2003)
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Protein

PCI domain-containing protein 2

Gene

Pcid2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (PubMed:20870947). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.By similarity1 Publication

GO - Molecular functionⁱ

double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
negative regulation of cysteine-type endopeptidase activity Source: MGI
nuclear retention of pre-mRNA at the site of transcription
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
poly(A)+ mRNA export from nucleus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of B cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
positive regulation of mitotic cell cycle spindle assembly checkpoint
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mRNA stability Source: UniProtKB
spleen development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
transcription elongation from RNA polymerase II promoter
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PCI domain-containing protein 2 Alternative name(s): CSN12-like protein
Gene namesⁱ	Name:Pcid2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:2443003 Pcid2

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000121030	2 – 399	PCI domain-containing protein 2Add BLAST		398

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineBy similarity		1
Modified residueⁱ	45	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8BFV2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BFV2
PaxDbⁱ	Q8BFV2
PRIDEⁱ	Q8BFV2

PTM databases

iPTMnetⁱ	Q8BFV2
PhosphoSitePlusⁱ	Q8BFV2

Expressionⁱ

Developmental stageⁱ

In B lineage cells, expressed in a stage-dependent manner at high levels in bone marrow pre-B and immature B-cells, and in spleen transitional 1 and follicular B-cells, but at lower levels in pro-B, transitional 2, and marginal zone B-cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000038542 Expressed in 291 organ(s), highest expression level in tracheobronchial tree
CleanExⁱ	MM_PCID2
ExpressionAtlasⁱ	Q8BFV2 baseline and differential
Genevisibleⁱ	Q8BFV2 MM

Interactionⁱ

Subunit structureⁱ

Belongs to the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. Interacts with BRCA2.By similarity

Protein-protein interaction databases

BioGridⁱ	231489, 2 interactors
IntActⁱ	Q8BFV2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000133204

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BFV2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	210 – 391	PCIPROSITE-ProRule annotationAdd BLAST		182

Sequence similaritiesⁱ

Belongs to the CSN12 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2688 Eukaryota COG5600 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001101
HOVERGENⁱ	HBG055800
InParanoidⁱ	Q8BFV2
OMAⁱ	SRKWGIY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09MD
PhylomeDBⁱ	Q8BFV2
TreeFamⁱ	TF106136

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000717 PCI_dom IPR036388 WH-like_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q8BFV2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAHITINQYL QQVYEAIDTR DGASCAELVS FKHPHVANPR LQMASPEEKC 
        60         70         80         90        100
QQVLEPPYDE MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE 
       110        120        130        140        150
ENWALPVMYA VALDLRIFAN NADQQLVKKG KSKVGDMLEK AAELLMSCFR 
       160        170        180        190        200
VCASDTRAGI EDSKKWGMLF LVNQLFKIYF KINKLHLCKP LIRAIDSSNL 
       210        220        230        240        250
KDDYSTAQRI TYKYYVGRKA MFDSDFKQAE EYLSFAFEHC HRSSQKNKRM 
       260        270        280        290        300
ILIYLLPVKM LLGHMPTIEL LRKYHLMQFS EVTKAVSEGN LLLLNEALAK 
       310        320        330        340        350
HETFFIRCGI FLILEKLKII TYRNLFKKVY LLLKTHQLSL DAFLVALKFM 
       360        370        380        390 
HVEDVDIDEV QCILANLIYM GHIKGYISHQ HQKLVVSKQN PFPPLSTVC

Length:399

Mass (Da):46,132

Last modified:March 1, 2003 - v1

Checksum:ⁱEA4B7DC9891D59F7

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9Q1H5	E9Q1H5_MOUSE	PCI domain-containing protein 2 PCI domain-containing protein 2	Pcid2	128	Annotation score:
E9Q5V9	E9Q5V9_MOUSE	PCI domain-containing protein 2 PCI domain-containing protein 2	Pcid2	52	Annotation score:
F6QZZ3	F6QZZ3_MOUSE	PCI domain-containing protein 2 PCI domain-containing protein 2	Pcid2	23	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	227	K → N in BAC31414 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK045796 mRNA Translation: BAC32494.1 AK042945 mRNA Translation: BAC31414.1 AK048722 mRNA Translation: BAC33434.1 AK163697 mRNA Translation: BAE37463.1 BC118533 mRNA Translation: AAI18534.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS52484.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848823.2, NM_178708.3
UniGeneⁱ	Mm.103427

Genome annotation databases

Ensemblⁱ	ENSMUST00000164416; ENSMUSP00000133204; ENSMUSG00000038542
GeneIDⁱ	234069
KEGGⁱ	mmu:234069
UCSC genome browser More...UCSCⁱ	uc012fzt.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q8BFV2	Pcid2 protein (Fragment)		MOUSE		398	UniRef100_Q8BFV2
UPI000047AC9A		MOUSE		232

Protein	Similar proteins		Species	Score	Length	Source
Q8BFV2	PCI domain-containing protein 2	)	HUMAN		399	UniRef90_Q5JVF3
PCI domain containing 2		PANTR		399
PCI domain containing 2		AILME		401
PCI domain-containing protein 2 isoform X1		BALAS		399
Uncharacterized protein		AOTNA		399
+92

Protein	Similar proteins		Species	Score	Length	Source
Q8BFV2	PCI domain-containing protein 2	)	HUMAN		399	UniRef50_Q5JVF3
PCI domain-containing protein 2		DANRE		399
PCI domain-containing protein 2		XENLA		399
PCI domain-containing protein 2		BOVIN		408
PCI domain containing 2		PANTR		399
+509

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK045796 mRNA Translation: BAC32494.1 AK042945 mRNA Translation: BAC31414.1 AK048722 mRNA Translation: BAC33434.1 AK163697 mRNA Translation: BAE37463.1 BC118533 mRNA Translation: AAI18534.1
CCDSⁱ	CCDS52484.1
RefSeqⁱ	NP_848823.2, NM_178708.3
UniGeneⁱ	Mm.103427

3D structure databases

ProteinModelPortalⁱ	Q8BFV2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	231489, 2 interactors
IntActⁱ	Q8BFV2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000133204

PTM databases

iPTMnetⁱ	Q8BFV2
PhosphoSitePlusⁱ	Q8BFV2

Proteomic databases

EPDⁱ	Q8BFV2
MaxQBⁱ	Q8BFV2
PaxDbⁱ	Q8BFV2
PRIDEⁱ	Q8BFV2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000164416; ENSMUSP00000133204; ENSMUSG00000038542
GeneIDⁱ	234069
KEGGⁱ	mmu:234069
UCSCⁱ	uc012fzt.1 mouse

Organism-specific databases

CTDⁱ	55795
MGIⁱ	MGI:2443003 Pcid2

Phylogenomic databases

eggNOGⁱ	KOG2688 Eukaryota COG5600 LUCA
GeneTreeⁱ	ENSGT00390000001101
HOVERGENⁱ	HBG055800
InParanoidⁱ	Q8BFV2
OMAⁱ	SRKWGIY
OrthoDBⁱ	EOG091G09MD
PhylomeDBⁱ	Q8BFV2
TreeFamⁱ	TF106136

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BFV2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038542 Expressed in 291 organ(s), highest expression level in tracheobronchial tree
CleanExⁱ	MM_PCID2
ExpressionAtlasⁱ	Q8BFV2 baseline and differential
Genevisibleⁱ	Q8BFV2 MM

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000717 PCI_dom IPR036388 WH-like_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PCID2_MOUSE
Accessionⁱ	Q8BFV2Primary (citable) accession number: Q8BFV2 Secondary accession number(s): Q147Z6, Q8C951
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BFV2 (PCID2_MOUSE)

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PCI domain-containing protein 2

Pcid2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ