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UniProtKB - Q8BFT9 (SVOP_MOUSE)
Protein
Synaptic vesicle 2-related protein
Gene
Svop
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.1.82.3, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptic vesicle 2-related proteinShort name: SV2-related protein |
Gene namesi | Name:Svop |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915916, Svop |
VEuPathDBi | HostDB:ENSMUSG00000042078 |
Subcellular locationi
Other locations
- synaptic vesicle membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- integral component of membrane Source: UniProtKB-KW
- synaptic vesicle Source: HGNC-UCL
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 87 | CytoplasmicSequence analysisAdd BLAST | 87 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 109 – 122 | VesicularSequence analysisAdd BLAST | 14 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 156 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 180 | VesicularSequence analysis | 3 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 202 – 209 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 210 – 230 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 231 – 238 | VesicularSequence analysis | 8 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 316 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 317 – 337 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 338 – 373 | VesicularSequence analysisAdd BLAST | 36 | |
Transmembranei | 374 – 394 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 395 – 401 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 423 – 424 | VesicularSequence analysis | 2 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 457 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 458 – 478 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 479 – 489 | VesicularSequence analysisAdd BLAST | 11 | |
Transmembranei | 490 – 510 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 511 – 548 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279453 | 1 – 548 | Synaptic vesicle 2-related proteinAdd BLAST | 548 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 542 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q8BFT9 |
PaxDbi | Q8BFT9 |
PRIDEi | Q8BFT9 |
ProteomicsDBi | 254727 |
PTM databases
iPTMneti | Q8BFT9 |
PhosphoSitePlusi | Q8BFT9 |
SwissPalmi | Q8BFT9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000042078, Expressed in cerebellum and 151 other tissues |
Genevisiblei | Q8BFT9, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000050730 |
Miscellaneous databases
RNActi | Q8BFT9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 521 – 548 | DisorderedSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0253, Eukaryota KOG0255, Eukaryota |
GeneTreei | ENSGT00940000155403 |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q8BFT9 |
OMAi | EIFPTKD |
OrthoDBi | 1430447at2759 |
PhylomeDBi | Q8BFT9 |
TreeFami | TF313465 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004749, Orgcat_transp/SVOP |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00898, 2A0119, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8BFT9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDAA SGEHDIQIEG VRVGLEAIEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG RFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF IGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVLLAVF VMPSLGWRWL LLLSAAPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSK EDYMDLLWTT LSEFPGVLVT LWVIDRLGRK
410 420 430 440 450
KTMALCFIIF SLCSLLLFIC IGRNVLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AGVASCFLPI ETKGRALQES SHREWGQEMV GRGTNSAGVP RSDSGSQE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z379 | D3Z379_MOUSE | Synaptic vesicle 2-related protein | Svop | 172 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | L → F in AAH59878 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 23 | A → T in BAC33150 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK047764 mRNA Translation: BAC33150.1 AK053833 mRNA Translation: BAC35546.1 AK082744 mRNA Translation: BAC38595.1 BC059878 mRNA Translation: AAH59878.1 |
CCDSi | CCDS39220.1 |
RefSeqi | NP_081081.1, NM_026805.1 |
Genome annotation databases
Ensembli | ENSMUST00000058472; ENSMUSP00000050730; ENSMUSG00000042078 |
GeneIDi | 68666 |
KEGGi | mmu:68666 |
UCSCi | uc008yzb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK047764 mRNA Translation: BAC33150.1 AK053833 mRNA Translation: BAC35546.1 AK082744 mRNA Translation: BAC38595.1 BC059878 mRNA Translation: AAH59878.1 |
CCDSi | CCDS39220.1 |
RefSeqi | NP_081081.1, NM_026805.1 |
3D structure databases
AlphaFoldDBi | Q8BFT9 |
SMRi | Q8BFT9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000050730 |
Protein family/group databases
TCDBi | 2.A.1.82.3, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | Q8BFT9 |
PhosphoSitePlusi | Q8BFT9 |
SwissPalmi | Q8BFT9 |
Proteomic databases
MaxQBi | Q8BFT9 |
PaxDbi | Q8BFT9 |
PRIDEi | Q8BFT9 |
ProteomicsDBi | 254727 |
Protocols and materials databases
ABCDi | Q8BFT9, 2 sequenced antibodies |
Antibodypediai | 9307, 125 antibodies from 25 providers |
DNASUi | 68666 |
Genome annotation databases
Ensembli | ENSMUST00000058472; ENSMUSP00000050730; ENSMUSG00000042078 |
GeneIDi | 68666 |
KEGGi | mmu:68666 |
UCSCi | uc008yzb.1, mouse |
Organism-specific databases
CTDi | 55530 |
MGIi | MGI:1915916, Svop |
VEuPathDBi | HostDB:ENSMUSG00000042078 |
Phylogenomic databases
eggNOGi | KOG0253, Eukaryota KOG0255, Eukaryota |
GeneTreei | ENSGT00940000155403 |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q8BFT9 |
OMAi | EIFPTKD |
OrthoDBi | 1430447at2759 |
PhylomeDBi | Q8BFT9 |
TreeFami | TF313465 |
Miscellaneous databases
BioGRID-ORCSi | 68666, 0 hits in 72 CRISPR screens |
ChiTaRSi | Svop, mouse |
PROi | PR:Q8BFT9 |
RNActi | Q8BFT9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042078, Expressed in cerebellum and 151 other tissues |
Genevisiblei | Q8BFT9, MM |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004749, Orgcat_transp/SVOP |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00898, 2A0119, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SVOP_MOUSE | |
Accessioni | Q8BFT9Primary (citable) accession number: Q8BFT9 Secondary accession number(s): Q6PB56, Q8BKY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families