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Entry version 110 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Transmembrane protein 229B

Gene

TMEM229B

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 229B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM229B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444389 Tmem229b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 40ExtracellularSequence analysis5
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 73CytoplasmicSequence analysisAdd BLAST12
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 109ExtracellularSequence analysisAdd BLAST15
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 167CytoplasmicSequence analysisAdd BLAST37

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002636821 – 167Transmembrane protein 229BAdd BLAST167

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BFQ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BFQ2

PRoteomics IDEntifications database

More...
PRIDEi
Q8BFQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046157 Expressed in 246 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BFQ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BFQ2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000053835

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM229 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH50 Eukaryota
ENOG410ZYMY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010899

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007583

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BFQ2

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEFTTGY

Database of Orthologous Groups

More...
OrthoDBi
1476201at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BFQ2

TreeFam database of animal gene trees

More...
TreeFami
TF336481

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010540 CmpB_TMEM229

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06541 ABC_trans_CmpB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BFQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNFNWK FPGVTSVWAL
60 70 80 90 100
FIYGTSILIV ERMYLRLRGR CPLLVRCVIY TLWTYLWEFT TGFILRQFNA
110 120 130 140 150
CPWDYSQFDF DFMGLITLEY AVPWFCGALI MEQFIIRNTL RLRFDKDAEP
160
GEPASPPALA NGHVKTD
Length:167
Mass (Da):19,561
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF380B0640BDD79E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZR6G3UZR6_MOUSE
Transmembrane protein 229B
Tmem229b
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC28272 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128A → G in BAE29169 (PubMed:16141072).Curated1
Sequence conflicti153P → S in AAH79613 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK031901 mRNA Translation: BAC27598.1
AK033403 mRNA Translation: BAC28272.1 Frameshift.
AK036593 mRNA Translation: BAC29498.1
AK053623 mRNA Translation: BAC35450.1
AK149922 mRNA Translation: BAE29169.1
AK151405 mRNA Translation: BAE30372.1
AK169759 mRNA Translation: BAE41349.1
BC066067 mRNA Translation: AAH66067.1
BC079613 mRNA Translation: AAH79613.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26005.1

NCBI Reference Sequences

More...
RefSeqi
NP_001163872.1, NM_001170401.1
NP_848860.1, NM_178745.4
XP_006515972.1, XM_006515909.2
XP_006515973.1, XM_006515910.3
XP_006515975.1, XM_006515912.3
XP_006515976.1, XM_006515913.1
XP_006515977.1, XM_006515914.1
XP_006515978.1, XM_006515915.3
XP_011242419.1, XM_011244117.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000056660; ENSMUSP00000053835; ENSMUSG00000046157
ENSMUST00000070174; ENSMUSP00000070637; ENSMUSG00000046157
ENSMUST00000174072; ENSMUSP00000134376; ENSMUSG00000046157
ENSMUST00000174697; ENSMUSP00000134348; ENSMUSG00000046157

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
268567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:268567

UCSC genome browser

More...
UCSCi
uc007nzm.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031901 mRNA Translation: BAC27598.1
AK033403 mRNA Translation: BAC28272.1 Frameshift.
AK036593 mRNA Translation: BAC29498.1
AK053623 mRNA Translation: BAC35450.1
AK149922 mRNA Translation: BAE29169.1
AK151405 mRNA Translation: BAE30372.1
AK169759 mRNA Translation: BAE41349.1
BC066067 mRNA Translation: AAH66067.1
BC079613 mRNA Translation: AAH79613.1
CCDSiCCDS26005.1
RefSeqiNP_001163872.1, NM_001170401.1
NP_848860.1, NM_178745.4
XP_006515972.1, XM_006515909.2
XP_006515973.1, XM_006515910.3
XP_006515975.1, XM_006515912.3
XP_006515976.1, XM_006515913.1
XP_006515977.1, XM_006515914.1
XP_006515978.1, XM_006515915.3
XP_011242419.1, XM_011244117.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053835

Proteomic databases

MaxQBiQ8BFQ2
PaxDbiQ8BFQ2
PRIDEiQ8BFQ2

Genome annotation databases

EnsembliENSMUST00000056660; ENSMUSP00000053835; ENSMUSG00000046157
ENSMUST00000070174; ENSMUSP00000070637; ENSMUSG00000046157
ENSMUST00000174072; ENSMUSP00000134376; ENSMUSG00000046157
ENSMUST00000174697; ENSMUSP00000134348; ENSMUSG00000046157
GeneIDi268567
KEGGimmu:268567
UCSCiuc007nzm.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
161145
MGIiMGI:2444389 Tmem229b

Phylogenomic databases

eggNOGiENOG410IH50 Eukaryota
ENOG410ZYMY LUCA
GeneTreeiENSGT00390000010899
HOGENOMiHOG000007583
InParanoidiQ8BFQ2
OMAiWEFTTGY
OrthoDBi1476201at2759
PhylomeDBiQ8BFQ2
TreeFamiTF336481

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tmem229b mouse

Protein Ontology

More...
PROi
PR:Q8BFQ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046157 Expressed in 246 organ(s), highest expression level in embryo
ExpressionAtlasiQ8BFQ2 baseline and differential
GenevisibleiQ8BFQ2 MM

Family and domain databases

InterProiView protein in InterPro
IPR010540 CmpB_TMEM229
PfamiView protein in Pfam
PF06541 ABC_trans_CmpB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT229B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BFQ2
Secondary accession number(s): Q3UDU2, Q6AXE5, Q8CCD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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