UniProtKB - Q8BFQ1 (Q8BFQ1_MOUSE)
Protein
Prosaposin
Gene
Psap
Organism
Mus musculus (Mouse)
Status
Functioni
Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.UniRule annotation
Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.UniRule annotation
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB-UniRule
- regulation of lipid metabolic process Source: UniProtKB-UniRule
- sphingolipid metabolic process Source: UniProtKB-UniRule
Names & Taxonomyi
Protein namesi | Recommended name: ProsaposinUniRule annotation |
Gene namesi | Name:PsapImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97783, Psap |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-UniRule
Lysosome
- lysosome Source: InterPro
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | UniRule annotationAdd BLAST | 16 | |
ChainiPRO_5015099031 | 17 – 554 | ProsaposinUniRule annotationAdd BLAST | 538 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 63 ↔ 138 | UniRule annotation | ||
Disulfide bondi | 66 ↔ 132 | UniRule annotation | ||
Disulfide bondi | 94 ↔ 106 | UniRule annotation | ||
Disulfide bondi | 197 ↔ 270 | UniRule annotation | ||
Disulfide bondi | 200 ↔ 264 | UniRule annotation | ||
Disulfide bondi | 229 ↔ 240 | UniRule annotation | ||
Disulfide bondi | 314 ↔ 387 | UniRule annotation | ||
Disulfide bondi | 317 ↔ 381 | UniRule annotation | ||
Disulfide bondi | 345 ↔ 356 | UniRule annotation | ||
Disulfide bondi | 439 ↔ 512 | UniRule annotation | ||
Disulfide bondi | 442 ↔ 506 | UniRule annotation | ||
Disulfide bondi | 470 ↔ 481 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | Q8BFQ1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004207, Expressed in stroma of bone marrow and 370 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 58 | Saposin A-typeInterPro annotationAdd BLAST | 41 | |
Domaini | 59 – 142 | Saposin B-typeInterPro annotationAdd BLAST | 84 | |
Domaini | 193 – 274 | Saposin B-typeInterPro annotationAdd BLAST | 82 | |
Domaini | 310 – 391 | Saposin B-typeInterPro annotationAdd BLAST | 82 | |
Domaini | 435 – 516 | Saposin B-typeInterPro annotationAdd BLAST | 82 | |
Domaini | 518 – 554 | Saposin A-typeInterPro annotationAdd BLAST | 37 |
Keywords - Domaini
RepeatARBA annotation, SignalUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156695 |
OMAi | NIENQCD |
TreeFami | TF316942 |
Family and domain databases
InterProi | View protein in InterPro IPR003119, SAP_A IPR007856, SapB_1 IPR008138, SapB_2 IPR008373, Saposin IPR011001, Saposin-like IPR021165, Saposin_chordata IPR008139, SaposinB_dom |
Pfami | View protein in Pfam PF02199, SapA, 2 hits PF05184, SapB_1, 3 hits PF03489, SapB_2, 4 hits |
PIRSFi | PIRSF002431, Saposin, 1 hit |
PRINTSi | PR01797, SAPOSIN |
SMARTi | View protein in SMART SM00162, SAPA, 2 hits SM00741, SapB, 4 hits |
SUPFAMi | SSF47862, SSF47862, 3 hits |
PROSITEi | View protein in PROSITE PS51110, SAP_A, 2 hits PS50015, SAP_B, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q8BFQ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYALALFASL LATALTSPVQ DPKTCSGGSA VLCRDVKTAV DCGAVKHCQQ
60 70 80 90 100
MVWSKPTAKS LPCDICKTVV TEAGNLLKDN ATQEEILHYL EKTCEWIHDS
110 120 130 140 150
SLSASCKEVV DSYLPVILDM IKGEMSNPGE VCSALNLCQS LQEYLAEQNQ
160 170 180 190 200
KQLESNKIPE VDMARVVAPF MSNIPLLLYP QDHPRSQPQP KANEDVCQDC
210 220 230 240 250
MKLVSDVQTA VKTNSSFIQG FVDHVKEDCD RLGPGVSDIC KNYVDQYSEV
260 270 280 290 300
CVQMLMHMQP KEICVLAGFC NEVKRVPMKT LVPATETIKN ILPALEMMDP
310 320 330 340 350
YEQNLVQAHN VILCQTCQFV MNKFSELIVN NATEELLVKG LSNACALLPD
360 370 380 390 400
PARTKCQEVV GTFGPSLLDI FIHEVNPSSL CGVIGLCAAR PELVEALEQP
410 420 430 440 450
APAIVSALLK EPTPPKQPAQ PKQSALPAHV PPQKNGGFCE VCKKLVLYLE
460 470 480 490 500
HNLEKNSTKE EILAALEKGC SFLPDPYQKQ CDDFVAEYEP LLLEILVEVM
510 520 530 540 550
DPGFVCSKIG VCPSAYKLLL GTEKCVWGPS YWCQNMETAA RCNAVDHCKR
HVWN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ61207 | SAP_MOUSE | Prosaposin | Psap Sgp1 | 557 | Annotation score: | ||
J3QPG5 | J3QPG5_MOUSE | Prosaposin | Psap | 557 | Annotation score: | ||
K3W4L3 | K3W4L3_MOUSE | Prosaposin | Psap | 556 | Annotation score: | ||
E9PZ00 | E9PZ00_MOUSE | Prosaposin | Psap | 551 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079082 Genomic DNA No translation available. BC145359 mRNA Translation: AAI45360.1 AK088369 mRNA Translation: BAC40308.1 AK089998 mRNA Translation: BAC41035.1 AK135637 mRNA Translation: BAE22597.1 AK145802 mRNA Translation: BAE26658.1 AK148152 mRNA Translation: BAE28378.1 AK150331 mRNA Translation: BAE29473.1 AK151034 mRNA Translation: BAE30051.1 AK151173 mRNA Translation: BAE30176.1 AK151230 mRNA Translation: BAE30222.1 AK151525 mRNA Translation: BAE30473.1 AK151686 mRNA Translation: BAE30610.1 AK151852 mRNA Translation: BAE30742.1 AK151891 mRNA Translation: BAE30775.1 AK151907 mRNA Translation: BAE30788.1 AK151943 mRNA Translation: BAE30819.1 AK152117 mRNA Translation: BAE30961.1 AK152126 mRNA Translation: BAE30967.1 AK152134 mRNA Translation: BAE30975.1 AK152203 mRNA Translation: BAE31032.1 AK152355 mRNA Translation: BAE31147.1 AK152505 mRNA Translation: BAE31272.1 AK152557 mRNA Translation: BAE31311.1 AK152605 mRNA Translation: BAE31352.1 AK152819 mRNA Translation: BAE31522.1 AK159108 mRNA Translation: BAE34824.1 AK159198 mRNA Translation: BAE34893.1 AK159266 mRNA Translation: BAE34946.1 AK159333 mRNA Translation: BAE34998.1 AK159341 mRNA Translation: BAE35003.1 AK159384 mRNA Translation: BAE35039.1 AK159427 mRNA Translation: BAE35074.1 AK159451 mRNA Translation: BAE35094.1 AK159457 mRNA Translation: BAE35099.1 AK159463 mRNA Translation: BAE35104.1 AK159487 mRNA Translation: BAE35122.1 AK159510 mRNA Translation: BAE35142.1 AK159528 mRNA Translation: BAE35157.1 AK159530 mRNA Translation: BAE35159.1 AK159589 mRNA Translation: BAE35209.1 AK159604 mRNA Translation: BAE35223.1 AK159657 mRNA Translation: BAE35266.1 AK159685 mRNA Translation: BAE35288.1 AK159720 mRNA Translation: BAE35315.1 AK159728 mRNA Translation: BAE35322.1 AK159840 mRNA Translation: BAE35418.1 AK159861 mRNA Translation: BAE35435.1 AK159862 mRNA Translation: BAE35436.1 AK159877 mRNA Translation: BAE35449.1 AK159910 mRNA Translation: BAE35473.1 AK159915 mRNA Translation: BAE35478.1 AK159936 mRNA Translation: BAE35496.1 AK159982 mRNA Translation: BAE35533.1 AK159994 mRNA Translation: BAE35544.1 AK160015 mRNA Translation: BAE35561.1 AK160024 mRNA Translation: BAE35567.1 AK160046 mRNA Translation: BAE35588.1 AK160877 mRNA Translation: BAE36065.1 AK161313 mRNA Translation: BAE36317.1 AK166700 mRNA Translation: BAE38955.1 AK166707 mRNA Translation: BAE38961.1 AK166744 mRNA Translation: BAE38986.1 AK166811 mRNA Translation: BAE39038.1 AK166849 mRNA Translation: BAE39068.1 AK166879 mRNA Translation: BAE39090.1 AK166909 mRNA Translation: BAE39110.1 AK166920 mRNA Translation: BAE39117.1 AK167014 mRNA Translation: BAE39190.1 AK167025 mRNA Translation: BAE39198.1 AK167111 mRNA Translation: BAE39259.1 AK167237 mRNA Translation: BAE39359.1 AK167418 mRNA Translation: BAE39506.1 AK170416 mRNA Translation: BAE41782.1 |
RefSeqi | NP_001139592.1, NM_001146120.1 |
Genome annotation databases
Ensembli | ENSMUST00000105465; ENSMUSP00000101105; ENSMUSG00000004207 |
GeneIDi | 19156 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079082 Genomic DNA No translation available. BC145359 mRNA Translation: AAI45360.1 AK088369 mRNA Translation: BAC40308.1 AK089998 mRNA Translation: BAC41035.1 AK135637 mRNA Translation: BAE22597.1 AK145802 mRNA Translation: BAE26658.1 AK148152 mRNA Translation: BAE28378.1 AK150331 mRNA Translation: BAE29473.1 AK151034 mRNA Translation: BAE30051.1 AK151173 mRNA Translation: BAE30176.1 AK151230 mRNA Translation: BAE30222.1 AK151525 mRNA Translation: BAE30473.1 AK151686 mRNA Translation: BAE30610.1 AK151852 mRNA Translation: BAE30742.1 AK151891 mRNA Translation: BAE30775.1 AK151907 mRNA Translation: BAE30788.1 AK151943 mRNA Translation: BAE30819.1 AK152117 mRNA Translation: BAE30961.1 AK152126 mRNA Translation: BAE30967.1 AK152134 mRNA Translation: BAE30975.1 AK152203 mRNA Translation: BAE31032.1 AK152355 mRNA Translation: BAE31147.1 AK152505 mRNA Translation: BAE31272.1 AK152557 mRNA Translation: BAE31311.1 AK152605 mRNA Translation: BAE31352.1 AK152819 mRNA Translation: BAE31522.1 AK159108 mRNA Translation: BAE34824.1 AK159198 mRNA Translation: BAE34893.1 AK159266 mRNA Translation: BAE34946.1 AK159333 mRNA Translation: BAE34998.1 AK159341 mRNA Translation: BAE35003.1 AK159384 mRNA Translation: BAE35039.1 AK159427 mRNA Translation: BAE35074.1 AK159451 mRNA Translation: BAE35094.1 AK159457 mRNA Translation: BAE35099.1 AK159463 mRNA Translation: BAE35104.1 AK159487 mRNA Translation: BAE35122.1 AK159510 mRNA Translation: BAE35142.1 AK159528 mRNA Translation: BAE35157.1 AK159530 mRNA Translation: BAE35159.1 AK159589 mRNA Translation: BAE35209.1 AK159604 mRNA Translation: BAE35223.1 AK159657 mRNA Translation: BAE35266.1 AK159685 mRNA Translation: BAE35288.1 AK159720 mRNA Translation: BAE35315.1 AK159728 mRNA Translation: BAE35322.1 AK159840 mRNA Translation: BAE35418.1 AK159861 mRNA Translation: BAE35435.1 AK159862 mRNA Translation: BAE35436.1 AK159877 mRNA Translation: BAE35449.1 AK159910 mRNA Translation: BAE35473.1 AK159915 mRNA Translation: BAE35478.1 AK159936 mRNA Translation: BAE35496.1 AK159982 mRNA Translation: BAE35533.1 AK159994 mRNA Translation: BAE35544.1 AK160015 mRNA Translation: BAE35561.1 AK160024 mRNA Translation: BAE35567.1 AK160046 mRNA Translation: BAE35588.1 AK160877 mRNA Translation: BAE36065.1 AK161313 mRNA Translation: BAE36317.1 AK166700 mRNA Translation: BAE38955.1 AK166707 mRNA Translation: BAE38961.1 AK166744 mRNA Translation: BAE38986.1 AK166811 mRNA Translation: BAE39038.1 AK166849 mRNA Translation: BAE39068.1 AK166879 mRNA Translation: BAE39090.1 AK166909 mRNA Translation: BAE39110.1 AK166920 mRNA Translation: BAE39117.1 AK167014 mRNA Translation: BAE39190.1 AK167025 mRNA Translation: BAE39198.1 AK167111 mRNA Translation: BAE39259.1 AK167237 mRNA Translation: BAE39359.1 AK167418 mRNA Translation: BAE39506.1 AK170416 mRNA Translation: BAE41782.1 |
RefSeqi | NP_001139592.1, NM_001146120.1 |
3D structure databases
SMRi | Q8BFQ1 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q8BFQ1 |
Protocols and materials databases
Antibodypediai | 1388, 457 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000105465; ENSMUSP00000101105; ENSMUSG00000004207 |
GeneIDi | 19156 |
Organism-specific databases
CTDi | 5660 |
MGIi | MGI:97783, Psap |
Phylogenomic databases
GeneTreei | ENSGT00940000156695 |
OMAi | NIENQCD |
TreeFami | TF316942 |
Miscellaneous databases
BioGRID-ORCSi | 19156, 0 hits in 17 CRISPR screens |
ChiTaRSi | Psap, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004207, Expressed in stroma of bone marrow and 370 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR003119, SAP_A IPR007856, SapB_1 IPR008138, SapB_2 IPR008373, Saposin IPR011001, Saposin-like IPR021165, Saposin_chordata IPR008139, SaposinB_dom |
Pfami | View protein in Pfam PF02199, SapA, 2 hits PF05184, SapB_1, 3 hits PF03489, SapB_2, 4 hits |
PIRSFi | PIRSF002431, Saposin, 1 hit |
PRINTSi | PR01797, SAPOSIN |
SMARTi | View protein in SMART SM00162, SAPA, 2 hits SM00741, SapB, 4 hits |
SUPFAMi | SSF47862, SSF47862, 3 hits |
PROSITEi | View protein in PROSITE PS51110, SAP_A, 2 hits PS50015, SAP_B, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8BFQ1_MOUSE | |
Accessioni | Q8BFQ1Primary (citable) accession number: Q8BFQ1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |