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Entry version 121 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Capsid protein VP0

Gene
N/A
Organism
Human parechovirus 3
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase, Viral ion channelARBA annotation
Biological processHost-virus interaction, Ion transport, Transport, Viral attachment to host cellARBA annotation, Viral RNA replicationARBA annotation, Virus entry into host cell
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Capsid protein VP0ARBA annotation
Alternative name(s):
Capsid protein VP1ARBA annotation
Capsid protein VP3ARBA annotation
Genome polyproteinARBA annotation
P1CARBA annotation
P1DARBA annotation
Protein 2CARBA annotation
Protein 3AARBA annotation
Virion protein 1ARBA annotation
Virion protein 3ARBA annotation
protein 2BARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman parechovirus 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri195055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesPicornaviridaeParechovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000098646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Capsid protein, Host cytoplasmARBA annotation, Host cytoplasmic vesicleARBA annotation, T=pseudo3 icosahedral capsid proteinARBA annotation, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Covalent protein-RNA linkageARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BES5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1154 – 1315SF3 helicaseInterPro annotationAdd BLAST162
Domaini1515 – 1705Peptidase C3InterPro annotationAdd BLAST191
Domaini1942 – 2056RdRp catalyticInterPro annotationAdd BLAST115

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00205, rhv_like, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 1 hit
2.60.120.20, 4 hits
3.30.70.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR004004, Helic/Pol/Pept_Calicivir-typ
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR027417, P-loop_NTPase
IPR044067, PCV_3C_PRO
IPR000199, Peptidase_C3A/C3B_picornavir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001676, Picornavirus_capsid
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR033703, Rhv-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR029053, Viral_coat
IPR009419, VPP_parechovir_P3A
IPR009407, VPP_parechovir_P3B

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06344, Parecho_VpG, 1 hit
PF00548, Peptidase_C3, 1 hit
PF06363, Picorna_P3A, 1 hit
PF00680, RdRP_1, 1 hit
PF00073, Rhv, 1 hit
PF00910, RNA_helicase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00918, CALICVIRUSNS

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51874, PCV_3C_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BES5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESIKDLVNV ATGAMDTLSL SNVETEVNNI ISGNEVGGEI ITKVADDASN
60 70 80 90 100
LLGPNSFATT AQPENKDVVQ ATTTVNTTNL TQHPSAPTIP FTPDFKNVDN
110 120 130 140 150
FHSMAYDITT GDKNPSKLIR LDTASWQTSY SRQYEITTVE LPKSFWDDTR
160 170 180 190 200
KPAYGQAKYF AAVRCGFHFQ VQVNVNQGTA GSALVVYEPK PVIDSRQYLE
210 220 230 240 250
FGSLTNLPHV LMNLAETTQA DLCIPYVADT NYVKTDSSDL GQLRVYVWTP
260 270 280 290 300
LSVPTGASNE VDVTVMGSLL QLDFQNPRPY GEDVDIYDNG PNKANVSKFN
310 320 330 340 350
KRKFLTASTK YKWTRTKVDI AEGPGTMNMA NVLSTTGAQS VALVGERAFY
360 370 380 390 400
DPRTAGSKSR FDDMIKIAQL FSVMSDNTTP SSSSGIDKYG YFDWAATVAP
410 420 430 440 450
QNMVHRIVVN LAQFPNLTLF MNSYSYFRGF LIIRLSIYAS TFNRGRLRMG
460 470 480 490 500
FFPNCTHDTQ LELDNAIYTI CDIGSDNSFE LTIPYSFSTW MRKTHGHQLG
510 520 530 540 550
LFQVEVLNRL TYNSSSPNKV HCIVQGRLGD DAKFFCPTGS LVSFQNSWGS
560 570 580 590 600
QMDLTDPLCI EDNMENCKQS ISPNELGLTS AQDDGPLGNE KPNYFLNFRT
610 620 630 640 650
MNVDIFTVSH TKVDNIFGRA WYVTSHDFNN GDTWRQKLTF PKEGHGMLSQ
660 670 680 690 700
FFAYFTGEIN IHILYMAKQG FLRVAHTYDT EDNRKTFLSS NGVITIPAGE
710 720 730 740 750
QMTLSVPFYS NKPLRTVRHD SALGFLMCRP SMHGTTRTTV EVYVSLRCPN
760 770 780 790 800
FFFPVPAPKP TGSRATALSD ESPYVLTDNR KMQLAYLDRG FYKHYGIIVG
810 820 830 840 850
ESVYQLDSDD IFKTALTGKA RFTKTKLTPD WVIEEECELD YFRVKYLESS
860 870 880 890 900
VNSEHIFSVD HNCETIAKDI FGTHTLNQHQ AIGLVGTILL TAGLMSTIKT
910 920 930 940 950
PVNATTIKEF FNHAVEGDEQ GLSLLVQKCT TFFSSAATEI LDNDLVKFIV
960 970 980 990 1000
KILVRILCYM VLYCHKPNIL TTACLSTLLI MDVTSSSVLS PSCKALMQCL
1010 1020 1030 1040 1050
MDGDVKKLAE VVAESMSNTD DEEIKEQICD TVKYTKSILS NQGPFKGFNE
1060 1070 1080 1090 1100
VSTAFRHIDW WIHTLLKIKD MVLSVFKPSM ESKAIQWLER NKEHVCAILD
1110 1120 1130 1140 1150
YASDIIVESK DQTKMKSQEF YQKYTDCLSK FKPIMAICFR SCHNSISNTV
1160 1170 1180 1190 1200
YRLFQELARI PSRISTQNDL IRVEPIGIWI QGEPGQGKSF LTHTLSRQLQ
1210 1220 1230 1240 1250
KSCKLNGVYT NPTASEFMDG YDNQDIHLID DLGQTRKEKD IEMLCNCISS
1260 1270 1280 1290 1300
VPFIVPMAHL EEKGKFYTSK LVIATTNKSD FSSTVLQDSG ALKRRFPYIM
1310 1320 1330 1340 1350
HIRAAKAYSK AGKLNVSQAM STMATGECWE VSKNGRDWET LKLKDLVQKI
1360 1370 1380 1390 1400
TEDYQERQKN YDCWKQQLEN QTLDDLDDAV SYIKHNFPDA IPYIDEYLNI
1410 1420 1430 1440 1450
EMSTLIEQME AFIEPKPSVF KCFVTRVANQ TRKAAREVVE WFSSKIKSML
1460 1470 1480 1490 1500
SFVERNKAWL TVASAVTSAI SILLLVTKIF KKEDSKDERA YNPTLPVAKP
1510 1520 1530 1540 1550
KSTFPVSQRE FKNEAPYDGQ LEHIISQMAY ITGSTTGHLT HCAGYQHDEI
1560 1570 1580 1590 1600
ILHGHSIKYL EQEEDLTLHY KNKVFPIENP SVTQVTLGGK PMDLAILKCK
1610 1620 1630 1640 1650
LPFRFKKNSK YYTSKIGTES MLIWMTEQGI ITKEVKRVHH SGGIKTREGT
1660 1670 1680 1690 1700
ESTKTISYTV KSCKGMCGGL LISKVEGNFK ILGMHIAGNG EMGVAIPFNF
1710 1720 1730 1740 1750
LKNDMSDQGI VTEITPMQPM YINTKTQIHK SPVYGAVEVK MGPAVLSKSD
1760 1770 1780 1790 1800
PRLEEPVDCL IKKSAAKYRV NKFQVNNELW QGVKACVKSK FREIFGINGI
1810 1820 1830 1840 1850
VDMKTAILGT SHVNSMDLST SAGYSFVKSG YKKKDLICLE PFSVSSMLEK
1860 1870 1880 1890 1900
LVQDKFHALL KGNQITTIFN TCLKDELRKL DKISAGKTRC IEACEVDYCI
1910 1920 1930 1940 1950
VYRMIMMEIY DKIYQTPCYY SGLAVGINPY KDWHFMINAL NDYNYEMDYS
1960 1970 1980 1990 2000
QYDGSLSSML LWEAVEVLAY CHDSPDLVMQ LHKPVIDSDH VVFNERWLIH
2010 2020 2030 2040 2050
GGMPSGSPCT TVLNSLCNLM MCIYTTNLIS PGIDCLPIVY GDDVILSLDR
2060 2070 2080 2090 2100
EIDPEKLQGI MADSFGAEVT GSRKDEPPSL KPRLEVEFLK RKPGYFPEST
2110 2120 2130 2140 2150
FIVGKLDTEN MIQHLMWMKN FSTFKQQLQS YLMELCLHGK DTYLYYIKIL
2160 2170
DPYLKEWNIT VDDYDVVIAK LMPMVFD
Length:2,177
Mass (Da):245,823
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7868C6EACE1D72D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB084913 Genomic RNA Translation: BAC23086.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084913 Genomic RNA Translation: BAC23086.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6GV4electron microscopy2.80A1-289[»]
B546-774[»]
SMRiQ8BES5
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

CDDicd00205, rhv_like, 2 hits
Gene3Di2.40.10.10, 1 hit
2.60.120.20, 4 hits
3.30.70.270, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR004004, Helic/Pol/Pept_Calicivir-typ
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR027417, P-loop_NTPase
IPR044067, PCV_3C_PRO
IPR000199, Peptidase_C3A/C3B_picornavir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001676, Picornavirus_capsid
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR033703, Rhv-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR029053, Viral_coat
IPR009419, VPP_parechovir_P3A
IPR009407, VPP_parechovir_P3B
PfamiView protein in Pfam
PF06344, Parecho_VpG, 1 hit
PF00548, Peptidase_C3, 1 hit
PF06363, Picorna_P3A, 1 hit
PF00680, RdRP_1, 1 hit
PF00073, Rhv, 1 hit
PF00910, RNA_helicase, 1 hit
PRINTSiPR00918, CALICVIRUSNS
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51874, PCV_3C_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8BES5_9PICO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BES5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
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