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Entry version 66 (07 Oct 2020)
Sequence version 1 (01 Mar 2003)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Mirafiori lettuce virus (isolate Lettuce/Netherlands/LS301-O) (MiLV) (Mirafiori lettuce big-vein virus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N7-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 3 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56)
mRNA guanylyltransferase (EC:2.7.7.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMirafiori lettuce virus (isolate Lettuce/Netherlands/LS301-O) (MiLV) (Mirafiori lettuce big-vein virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri652964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeNegarnaviricotaHaploviricotinaMilneviricetesSerpentoviralesAspiviridaeOphiovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiLactuca sativa (Garden lettuce) [TaxID: 4236]

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003915011 – 2280RNA-directed RNA polymerase LAdd BLAST2280

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8BCV9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini638 – 804RdRp catalyticPROSITE-ProRule annotationAdd BLAST167

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014023, Mononeg_RNA_pol_cat

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BCV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDFMKEKKI NYLKTPYLRT LLESYKEDYV SLKSTIEAEK KKEAREIDVN
60 70 80 90 100
YPHILTDLIE RDRDEVVSLE KIGTPSVISK INSPYTEISE ENLNMIKGAL
110 120 130 140 150
YPEKWNRKAH LELLLFREFF LSRLDKESEI SYDLSQDGSI ELVKRLYNGG
160 170 180 190 200
YASPESNVVY KFANTLVSHE LSKIEMNMLG TQEMKFNEDE ISLDSAKKYW
210 220 230 240 250
VLDVLEHLNK NIMMKASARE NKRDAPDSID FYEGKRIKTN YFGVGSSISR
260 270 280 290 300
IEFENSLPPL VIFLSSTICG YYFEGEAKCF IGKAEMMNYS MYLADNLLTL
310 320 330 340 350
SLIRTKLSTE EKKFMDYYVS LLDQPLKTRV GMGALYETTC LLMSDQKTLS
360 370 380 390 400
SSMPILDNLI ESIEVSTEQT EIIVEVCISV GPETCIKMSS LGKTLILAST
410 420 430 440 450
NPSKGLSKYT QRTNRDNPVN INTIRRLRSL FRQRVIISYI EKHGRVPNLI
460 470 480 490 500
SVPEDLGAQL EMKAAGGNYL GHMISEISRY DSVRLGKFLD TGKEMNLQSR
510 520 530 540 550
IIDKACTKDS YDSENNSEKE IQYYISNDMK EVFKDPIAID RDQYKSKERL
560 570 580 590 600
VKVVHRKEPL MMPMKKYLNV RLSAKEKEQK TAARFYGIAS FKLKLWISST
610 620 630 640 650
MEMIKRAMKL LPGQMMTMTD DERRLIMFKM SEKLLSKNSY SLFLDYSGHN
660 670 680 690 700
TSQRPENTNF ILEEIANMYG YYEGTPEFNE LTSLSYVFSN INIIVEDSWS
710 720 730 740 750
DYVYISQGQL GAIEGWLGSL WGIQSQLMIE DMFMQLGMND YIGTTYSDDS
760 770 780 790 800
CGVFTQSSLD VHKLNGIIKN VQRYGEDMGL IVKLSQTQVT NGRCSMLKEH
810 820 830 840 850
YYRGKPMDMS IKKMMSISPN GPKLLGDELE SATLIDSGYT SSCTRASEIG
860 870 880 890 900
IQTLLRNFRI VKLLSNSTRK LIEDIDNDIL DERYLSSKNN YEISMKIAAK
910 920 930 940 950
NLSKNRLSSY IPAPRSRVIE FYQFHVTNEK VLDLYLMIMY SPYTLYGYAL
960 970 980 990 1000
TPMPDVLISG YSLSNVKRLA YLQGILGKEA LIVLSKLINL SGNALSYIDN
1010 1020 1030 1040 1050
PFPFVGGRKD TKLLIKPIIV KQLPKRVRNP ELLKLLSLQK DKEEINFKTK
1060 1070 1080 1090 1100
IVEVFENCFS SRIASKFYEC SIYSYISGVI SKVDNSTTMK MLLGGRKMMS
1110 1120 1130 1140 1150
LINDAWMRNH KLRIRLNDKG IMNYNELLFA RNQKVLKYKN DEEIKLNFLE
1160 1170 1180 1190 1200
IEEIPIMGKV KYSEYRNMMQ PIFKGSTKLT EQGKKNVPPQ KTFFNIAKFD
1210 1220 1230 1240 1250
RELGVDGMFE HKLIFQAYDL VRYVKWLMME QERFSKKMNE KDELNLTKLC
1260 1270 1280 1290 1300
NMTLHTFTDA SYHDLQEHVV CPKGGRYFHR ALTSGFNPKT GDLSSNIYSS
1310 1320 1330 1340 1350
SYDITGIDQL LAKTGGADNN LNIQYLLIYV RICLSLLRPS PNKLRSLTLT
1360 1370 1380 1390 1400
NDIYFNIKDV TFSLENLNDP GSSETLYEVA SRDKIQSRGK LYYNYSTYIE
1410 1420 1430 1440 1450
MDEDLENKFI DHVSTTRQEF IEKESAFRSV HSYMLDQMII SPELISDLIL
1460 1470 1480 1490 1500
EGLIGKKMIS KGRERFFDQF YKYYKSLNVI GAETPARSVI RGLLYEELFK
1510 1520 1530 1540 1550
VNPKSKKGEL WSTEIIKHGY SSGFKDSLMK LFILSTSLSY RMLDKQNGKM
1560 1570 1580 1590 1600
KLIVNLNRTV QNSKSNFERI RKGECQFYIK DKRITEMILN SFPTLGYTYS
1610 1620 1630 1640 1650
DVHQAATDVC CEISDMEFEQ VRLGSYYLKL HKAETNKIEG MVYGYVNFSE
1660 1670 1680 1690 1700
LEINYQDLLD NLGLESALKG FETACSLMVS PEQLSSPTLS AVYPSAKGLL
1710 1720 1730 1740 1750
DSLIGNGFIK NSDTIIELCG GRGDFHLAMM EKEIKHTTLS REDGYNLAMR
1760 1770 1780 1790 1800
IPGMTSKKVS FNCFRQSDYI PYFDHSIILL DISHITEKKD CLSGILGDCI
1810 1820 1830 1840 1850
TSKKKVILRL NGLNKFLNYE ILQELKMYEM KAYLPVLESP GYVYLTIDAS
1860 1870 1880 1890 1900
KKLEEEKQLD RKIFTDQLGY SRSILTCSLI NSISIVNLQG VISVPPKRVQ
1910 1920 1930 1940 1950
DQTMEVISDE VLTEMILEED PEYVHVNPEI KTQVKTADDF KDNLYVYISE
1960 1970 1980 1990 2000
KLSIKYKNKL KFLEERLITK GKIEKSENKP KNLIELARKI RRKESDTIEV
2010 2020 2030 2040 2050
DYRMLINSKV NIISGVTGMD HNELVEVLND AMSVKFNKRM SFECWKLILN
2060 2070 2080 2090 2100
LSANEKLIDS DLIVETINIQ KFRKDVDRTI NSSFEIASKA VISFKTGRIV
2110 2120 2130 2140 2150
EGLLAVARLD NVRRKSILNH KDKTTRNNIL HYKLYMNRIM IISQSMYVEP
2160 2170 2180 2190 2200
QFPGISDSKF GKIWRSLGSI ESDIDIERAN AALDSIESLN KFFKEMNDEY
2210 2220 2230 2240 2250
FSFLNNFDLS VDNMTERIKE ECQPIDALVD TLTTFGLEVT EEDIARNKEL
2260 2270 2280
DTWEKVQEYC GEEELFDAWA QEDIGDWGDE
Length:2,280
Mass (Da):262,635
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2FF37747BDC256C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF525933 Genomic RNA Translation: AAN60447.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525933 Genomic RNA Translation: AAN60447.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ8BCV9

Family and domain databases

InterProiView protein in InterPro
IPR014023, Mononeg_RNA_pol_cat
PROSITEiView protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_MILVL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BCV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: March 1, 2003
Last modified: October 7, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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