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UniProtKB - Q8BCR0 (POLN_RUBVN)

Entry version 96 (23 Feb 2022)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Non-structural polyprotein p200

Gene
N/A
Organism
Rubella virus (strain RN-UK86) (RUBV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable principal replicase for the negative-strand DNA, which replicates the 40S (+) genomic RNA into (-) antigenomic RNA. It cannot replicate the (-) into (+) until cleaved into p150 and p90 mature proteins.

By similarity

Protease that cleaves the precursor polyprotein into two mature products. Together with RNA-directed RNA polymerase p90, replicates the 40S genomic and antigenomic RNA by recognizing replications specific signals. The heterodimer P150/p90 is probably the principal replicase for positive-strand genomic RNA and the 24S subgenomic RNA, which codes for structural proteins. Responsible for the mRNA-capping of the viral mRNAs. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. Forms fibers late in the infection that may be involved in cell-to-cell spread of the virus RNA in the absence of virus particle formation.

By similarity

Together with protease/methyltransferase p150, replicates the 40S genomic and antigenomic RNA by recognizing replications specific signals. The heterodimer P150/p90 is probably the principal replicase for positive-strand genomic RNA and the 24S subgenomic RNA, which codes for structural proteins. A helicase activity is probably also present.

By similarity

Miscellaneous

Rubella virus in utero infection has frequently severe consequences on normal fetal development, collectively known as congenital rubella syndrome (CRS). The teratogenicity of the virus is possibly due to the interaction between the p90 protein and the human RB1/retinoblastoma protein.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+PROSITE-ProRule annotationNote: Zn2+ is necessary for the protease activity. The protease can also function efficiently with Cd2+ and Co2+.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1152For cysteine protease activityPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1175ZincPROSITE-ProRule annotation1
Metal bindingi1178ZincPROSITE-ProRule annotation1
Metal bindingi1227ZincPROSITE-ProRule annotation1
Active sitei1273For cysteine protease activityPROSITE-ProRule annotation1
Metal bindingi1273ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1352 – 1359NTPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...MEROPSi		C27.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-structural polyprotein p200
Short name:
p200
Cleaved into the following 2 chains:
Protease/methyltransferase p150 (EC:3.4.22.-)
Short name:
p150
RNA-directed RNA polymerase p90 (EC:2.7.7.48PROSITE-ProRule annotation, EC:3.6.1.15, EC:3.6.4.13)
Short name:
p90
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRubella virus (strain RN-UK86) (RUBV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri376267 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Kitrinoviricota › Alsuviricetes › Hepelivirales › Matonaviridae › Rubivirus › Rubivirus rubellae ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007186 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000008993 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002401701 – 2116Non-structural polyprotein p200Add BLAST2116
ChainiPRO_00002401711 – 1301Protease/methyltransferase p150Add BLAST1301
ChainiPRO_00002401721302 – 2116RNA-directed RNA polymerase p90Add BLAST815

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1301 – 1302Cleavage; autocatalyticPROSITE-ProRule annotation2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNA-directed RNA polymerase p90.

Interacts with host CALM1; this interaction is necessary for the protease activity and viral infectivity.

Interacts with host C1QBP.

Interacts with the capsid protein.

By similarity

Interacts with human RB1/retinoblastoma protein.

Interacts with protease/methyltransferase p150.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8BCR0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 247Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST191
Domaini806 – 985MacroPROSITE-ProRule annotationAdd BLAST180
Domaini1000 – 1301Peptidase C27PROSITE-ProRule annotationAdd BLAST302
Domaini1320 – 1468(+)RNA virus helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST149
Domaini1469 – 1609(+)RNA virus helicase C-terminalPROSITE-ProRule annotationAdd BLAST141
Domaini1870 – 1981RdRp catalyticPROSITE-ProRule annotationAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 49Required for efficient proteolysis and P150-P90 interactionBy similarityAdd BLAST14
Regioni715 – 781DisorderedSequence analysisAdd BLAST67
Regioni991 – 1030DisorderedSequence analysisAdd BLAST40
Regioni1152 – 1183Interaction with host CALM1PROSITE-ProRule annotationAdd BLAST32
Regioni1193 – 1228EF-hand-likePROSITE-ProRule annotationAdd BLAST36
Regioni1700 – 1900Involved in P150-P90 interactionBy similarityAdd BLAST201

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi727 – 732PxxPxR; class II SH3-bindingBy similarity6
Motifi747 – 752PxxPxR; class II SH3-bindingBy similarity6
Motifi761 – 766PxxPxR; class II SH3-bindingBy similarity6
Motifi1902 – 1906Human RB1 bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi747 – 771Pro residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus has a methyltransferase activity for mRNA-capping. The C-terminus harbors a protease active in cis or in trans which specifically cleaves and releases the two mature proteins. Both the N-terminus and C-terminus are required for fiber formation. The N-terminus is involved in associating with membranes. An EF-hand Ca2+-binding motif is present in the protease. Also contains 3 SH3-binding motifs that are responsible for the interaction with host C1QBP.By similarity

Family and domain databases

Conserved Domains Database

More...CDDi		cd21557, Macro_X_Nsp3-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.220.10, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR027417, P-loop_NTPase
IPR008738, Peptidase_C27
IPR007094, RNA-dir_pol_PSvirus
IPR022245, Rubi_NSP_C
IPR044070, RUBV_NS_PRO
IPR001788, Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01661, Macro, 1 hit
PF05407, Peptidase_C27, 1 hit
PF00978, RdRP_2, 1 hit
PF12601, Rubi_NSP_C, 1 hit
PF01443, Viral_helicase1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51154, MACRO, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51889, RUBV_NS_PRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BCR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLLDEVLA PGGPYNLTVG SWVRDHVRSI VEGAWEVRDV VSAAQKRAIV 
        60         70         80         90        100
AVIPRPVFTQ MQVSDHPALH AISRYTRRHW IEWGPKEALH VLIDPSPGLL 
       110        120        130        140        150
REVARVERRW VALCLHRTAR KLATALAETA SEAWHADYVC ALRGAPSGPF 
       160        170        180        190        200
YVHPEDVPHG GRAVADRCLL YYTPMQMCEL MRTIDATLLV AVDLWPVALA 
       210        220        230        240        250
AHVGDDWDDL GIAWHLDHDG GCPADCRGAG AGPTPGYTRP CTTRIYQVLP 
       260        270        280        290        300
DTAHPGRLYR CGPRLWTRDC AVAELSWEVA QHCGHQARVR AVRCTLPIRH 
       310        320        330        340        350
VRSLQPSARV RLPDLVHLAE VGRWRWFSLP RPVFQRMLSY CKTLSPDAYY 
       360        370        380        390        400
SERVFKFKNA LSHSITLAGN VLQEGWKGTC AEEDALCAYV AFRAWQSNAR 
       410        420        430        440        450
LAGIMKSAKR CAADSLSVAG WLDTIWDAIK RFFGSVPLAE RMEEWEQDAA 
       460        470        480        490        500
VAAFDRGPLE DGGRHLDTVQ PPKSPPRPEI AATWIVHAAS ADRHCACAPR 
       510        520        530        540        550
CDVPRERPSA PACPPDDEAL IPPWLFAERR ALRCREWDFE ALRARADTAA 
       560        570        580        590        600
APAPLAPRPA RYPTVLYRHP AHHGPWLTLD EPGEADAALV LCDPLGQPLR 
       610        620        630        640        650
GPERHFAAGA HMCAQARGLQ AFVRVVPPPE RPWADGGARA WAKFFRGCAW 
       660        670        680        690        700
AQRLLGEPAV MHLPYTDGDV PKLIALALRT LAQQGAALAL SVRDLPGGAA 
       710        720        730        740        750
FDANAVTAAV RAGPGQFAAT SPPPGDPPPP RRARRSQRHS DARGTPPPAP 
       760        770        780        790        800
ARDPPPPAPS PPAPPRAGDP DSPTSAEPAD RARHAELEVV YEPSGPPTST 
       810        820        830        840        850
KADPDSDIVE SYARAAGPVH LRVRDIMDPP PGCKVVVNAA NEGLLAGSGV 
       860        870        880        890        900
CGAIFANATA ALAADCRRLA PCPTGEAVAT PGHGCGYTHI IHAVAPRRPR 
       910        920        930        940        950
DPAALEEGEA LLERAYRSIV ALAAARRWAC VACPLLGAGV YGWSAAESLR 
       960        970        980        990       1000
AALAATRTEP AERVSLHICH PDRATLTHAS VLVGAGLAAR RVSPPPTEPL 
      1010       1020       1030       1040       1050
ASCPAGDLGR PAQRSASPPA TPLGDATAPE PRGCQGCELC RCTRVTNDRA 
      1060       1070       1080       1090       1100
YVNLWLERDR GATSWAMRIP EVVVYGPEHL ATHFPLNHYS VLKPAEVRPP 
      1110       1120       1130       1140       1150
RGMCGSDMWR CRGWQGMPQV RCTPSNAHAA LCRTGVPPRV STRGGELDPN 
      1160       1170       1180       1190       1200
TCWLRAAANV AQAARACGAY TSAGCPKCAY GRALSEARTH EDFAALSQRW 
      1210       1220       1230       1240       1250
SASHADASPD GTGDPLDPLM ETVGCACSRV WVGTEHEAPP DHLLVSLHRA 
      1260       1270       1280       1290       1300
PNGPWGVVLE VRARPEGGNP TGHFVCAVGG GPRRVSDRPH LWLAVPLSRG 
      1310       1320       1330       1340       1350
GGTCAATDEG LAQAYYDDLE VRRLGDDAMA RAALASVQRP RKGPYNIRVW 
      1360       1370       1380       1390       1400
NMAAGAGKTT RILAAFTRED LYVCPTNALL HEIQAKLRAR DIDIKNAATY 
      1410       1420       1430       1440       1450
ERALTKPLAA YRRIYIDEAF TLGGEYCAFV ASQTTAEVIC VGDRDQCGPH 
      1460       1470       1480       1490       1500
YANNCRTPVP DRWPTERSRH TWRFPDCWAA RLRAGLDYDI EGERTGTFAC 
      1510       1520       1530       1540       1550
NLWDGRQVDL HLAFSRETVR RLHEAGIRAY TVREAQGMSV GTACIHVGRD 
      1560       1570       1580       1590       1600
GTDVALALTR DLAIVSLTRA SDALYLHELE DGSLRAAGLS AFLDAGALAE 
      1610       1620       1630       1640       1650
LKEVPAGIDR VVAVEQAPPP LPPADGIPEA QDVPPFCPRT LEELVFGRAG 
      1660       1670       1680       1690       1700
HPHYADLNRV TEGEREVRYM RISRHLLNKN HTEMPGTERV LSAVCAVRRY 
      1710       1720       1730       1740       1750
RAGEDGSTLR TAVARQHPRP FRQIPPPRVT AGVAQEWRMT YLRERIDLTD 
      1760       1770       1780       1790       1800
VYTQMGVAAR ELTDRYARRY PEIFAGMCTA QSLSVPAFLK ATLKCVDAAL 
      1810       1820       1830       1840       1850
GPRDTEDCHA AQGKAGLEIR AWAKEWVQVM SPHFRAIQKI IMRALRPQFL 
      1860       1870       1880       1890       1900
VAAGHTEPEV DAWWQAHYTT NAIEVDFTEF DMNQTLATRD VELEISAALL 
      1910       1920       1930       1940       1950
GLPCAEDYRA LRAGSYCTLR ELGSTETGCE RTSGEPATLL HNTTVAMCMA 
      1960       1970       1980       1990       2000
MRMVPKGVRW AGIFQGDDMV IFLPEGARSA ALKWTPAEVG LFGFHIPVKH 
      2010       2020       2030       2040       2050
VSTPTPSFCG HVGTAAGLFH DVMHQAIKVL CRRFDPDVLE EQQVALLDRL 
      2060       2070       2080       2090       2100
RGVYAALPDT VAANAAYYDY SAERVLAIVR ELTAYARGRG LDHPATIGAL 
      2110 
EEIQTPYARA NLHDAD
Length:2,116
Mass (Da):230,559
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B187C7DD7C5D742
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti427D → G in strain: Isolate SUR-SK74 and ULR-GE84. 1
Natural varianti672K → Q in strain: Isolate SUR-SK74 and ULR-GE84. 1
Natural varianti697G → R in strain: Isolate ULR-GE84. 1
Natural varianti717F → L in strain: Isolate SUR-SK74. 1
Natural varianti723P → T in strain: Isolate SUR-SK74. 1
Natural varianti739H → P in strain: Isolate SUR-SK74. 1
Natural varianti751A → V in strain: Isolate SUR-SK74. 1
Natural varianti767A → V in strain: Isolate SUR-SK74. 1
Natural varianti771 – 772DS → VP in strain: Isolate SUR-SK74. 2
Natural varianti775S → T in strain: Isolate SUR-SK74. 1
Natural varianti799 – 800ST → PS in strain: Isolate SUR-SK74. 2
Natural varianti825D → N in strain: Isolate SUR-SK74 and ULR-GE84. 1
Natural varianti902P → H in strain: Isolate ULR-GE84. 1
Natural varianti930C → R in strain: Isolate SUR-SK74. 1
Natural varianti941Y → H in strain: Isolate SUR-SK74. 1
Natural varianti958T → A in strain: Isolate SUR-SK74. 1
Natural varianti1008L → P in strain: Isolate SUR-SK74. 1
Natural varianti1042C → Y in strain: Isolate SUR-SK74. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF533117 Genomic RNA Translation: AAN07181.1
AF435866 Genomic RNA Translation: AAL31567.1
AF435865 Genomic RNA Translation: AAL31565.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533117 Genomic RNA Translation: AAN07181.1
AF435866 Genomic RNA Translation: AAL31567.1
AF435865 Genomic RNA Translation: AAL31565.1

3D structure databases

SMRiQ8BCR0
ModBaseiSearch...

Protein family/group databases

MEROPSiC27.001

Family and domain databases

CDDicd21557, Macro_X_Nsp3-like, 1 hit
Gene3Di3.40.220.10, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR027417, P-loop_NTPase
IPR008738, Peptidase_C27
IPR007094, RNA-dir_pol_PSvirus
IPR022245, Rubi_NSP_C
IPR044070, RUBV_NS_PRO
IPR001788, Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF01661, Macro, 1 hit
PF05407, Peptidase_C27, 1 hit
PF00978, RdRP_2, 1 hit
PF12601, Rubi_NSP_C, 1 hit
PF01443, Viral_helicase1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51154, MACRO, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51889, RUBV_NS_PRO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLN_RUBVN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BCR0
Secondary accession number(s): Q8VA11, Q8VA13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2003
Last modified: February 23, 2022
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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