Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 86 (23 Feb 2022)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
Add a publicationFeedback
Protein

RNA1 polyprotein

Gene
N/A
Organism
Tomato black ring virus (strain MJ) (TBRV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Picornain 3C-like protease is a thiol protease that cleaves the P1 and P2 polyproteins.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1272For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei1310For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei1402For picornain 3C-like protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi781 – 788ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C03.025

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA1 polyprotein
Alternative name(s):
P1
Cleaved into the following 5 chains:
P1A protein
Short name:
1A
Alternative name(s):
protease cofactor
Putative ATP-dependent helicase (EC:3.6.4.-)
Alternative name(s):
1B
NTP-binding protein
Short name:
NTB
membrane-binding protein
Alternative name(s):
1C-VPg
Picornain 3C-like protease (EC:3.4.22.-)
Short name:
3C-like protease
Alternative name(s):
1D-PRO
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
1E-POL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTomato black ring virus (strain MJ) (TBRV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri283677 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesSecoviridaeComovirinaeNepovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAllium porrum (Leek) (Allium ampeloprasum var. porrum) [TaxID: 4681]
Apium graveolens (Celery) [TaxID: 4045]
Beta vulgaris (Sugar beet) [TaxID: 161934]
Fraxinus (ash trees) [TaxID: 38871]
Lactuca sativa (Garden lettuce) [TaxID: 4236]
Narcissus pseudonarcissus (Daffodil) [TaxID: 39639]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Robinia pseudoacacia (Black locust) [TaxID: 35938]
Rubus (bramble) [TaxID: 23216]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum tuberosum (Potato) [TaxID: 4113]
Tulipa [TaxID: 13305]
Vitis sp. (Grape) [TaxID: 3604]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini566 – 1158CytoplasmicBy similarityAdd BLAST593
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1159 – 1179HelicalBy similarityAdd BLAST21
Topological domaini1180 – 1205LumenalBy similarityAdd BLAST26

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000370751 – 565P1A proteinSequence analysisAdd BLAST565
ChainiPRO_0000037076566 – 1205Putative ATP-dependent helicaseSequence analysisAdd BLAST640
ChainiPRO_00000370771206 – 1232Viral genome-linked proteinBy similarityAdd BLAST27
ChainiPRO_00000370781233 – 1442Picornain 3C-like proteaseSequence analysisAdd BLAST210
ChainiPRO_00000370791443 – 2266RNA-directed RNA polymeraseSequence analysisAdd BLAST824

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages by picornain 3C-like protease in vivo yield mature proteins. Picornain 3C-like protease is autocatalytically processed (By similarity).By similarity
VPg is uridylylated by the polymerase and is covalently linked to the 5'-end of genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity

Keywords - PTMi

Covalent protein-RNA linkage

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8B8X3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini751 – 917SF3 helicasePROSITE-ProRule annotationAdd BLAST167
Domaini1229 – 1438Peptidase C3PROSITE-ProRule annotationAdd BLAST210
Domaini1715 – 1843RdRp catalyticPROSITE-ProRule annotationAdd BLAST129

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR044067, PCV_3C_PRO
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00680, RdRP_1, 1 hit
PF00910, RNA_helicase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51874, PCV_3C_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8B8X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVTLSPPGD CFTFNHVKYN NSLNKYLFYN NNLDIVLDDF DFYFNFYAKK
60 70 80 90 100
YNVLSSFFSD RVLSALYTPM SVSEAASLAL EDFCELALDK LKINPFHQLW
110 120 130 140 150
EETLANWPVY PGTSLLDFFR TQYEIRREVA EASAEALRLK KATRADAFAD
160 170 180 190 200
EVKFLIKNGV LPHLAGDFAR KIWSTGKDQK KTRTAFLVKI KKANQLKQQW
210 220 230 240 250
NSARSLAAAR AEVLREFEPS PQQIQKAIEA QLFAEKLGRK YATLTARVRA
260 270 280 290 300
KRAAARELRE KQLYQETVDL LNASLLPPME KVEIERKYRK VRPTGANVVH
310 320 330 340 350
QVVANPLGSL CPYMGLGAKT ADVRCQATLM AGKIHAQYPR LATAIYAWVI
360 370 380 390 400
GPAAHFECIT PVRNFVKGLT FMVDFFPEEA LIHELNEITT EAVCIGASMV
410 420 430 440 450
LDEERAKLEA HAQSANCRAN VFMKAMAGVK NMAKCAYTGF KTGCEEAGRS
460 470 480 490 500
LAEGICSVMM RSFRECIAQI KTELGCAIEM VEVMIKKVKD WFYSMLEKLQ
510 520 530 540 550
CGLETLGSYA MYALAILLGC GLTSLLERCI GGQGILTKLF ITGVLAAIGL
560 570 580 590 600
QAAGGFDNLQ REMVQLCTAL AAGIFDIQHA GNGKYKPSWD ITAEHAREDA
610 620 630 640 650
RDSNVRSIPI ISGVIEALAQ FGTGLCSMQS ATLIEIGKIG AACHSMRMGK
660 670 680 690 700
EALKEFCATL MYYLGRIADK VTGRETIFFD ELSTLVHVDV RGWIKRAQSC
710 720 730 740 750
MRESFHTEIG NQFFRDMVAQ LVDEGQKLQI GVNGIPRKIS ADYSQLIGQI
760 770 780 790 800
MKDLVELHKR TIRAGISEGR RCEPVWIYLF GQRHCGKSNF MSTLDNALAK
810 820 830 840 850
HFNLPNTTAY RNCKDAFYSG YSGQTFFHMD DLSSVKLEPP LEAELINLVS
860 870 880 890 900
CQEVPLNMAD LADKPIYFRS PFIISSSNFE DVPAGCGVRD IEAYRARKAC
910 920 930 940 950
LVEMRRKPGV IYDPENPLLA SQARFKDPMY QTLINGQTEE TSWMEMDDVV
960 970 980 990 1000
TEIINISARH RSAQEKLQAR YMREKALLDP LALASESFLV KEAQKVFLDF
1010 1020 1030 1040 1050
DGVELEKAGV PRPEGGHGLY VDGVLYLVNA SFEFDEIPIK DGGYQRLWDS
1060 1070 1080 1090 1100
RMRKKFLPAI QRDEHLNTKS MVVTGFLRSL VNGECAVLSK DTLTASATTA
1110 1120 1130 1140 1150
QLSIFKALRL EERVYLRTLQ HQLDLYSQDI PENPYCNSAW VKVLGAIGAG
1160 1170 1180 1190 1200
RDYLVQNGCG ILMIAAALIL ILVSGWGFWK LFVGLFSGTM SLGAAITGMS
1210 1220 1230 1240 1250
AVDIKAQQSS ASQEKGYRAR NIPIHHRYAY ARSQAGDGLL PAARLCVAIY
1260 1270 1280 1290 1300
QPGGGFVSAM QYKNKSVRMT RHQALRFKEG EQLTVIFAST GESQLIRWHK
1310 1320 1330 1340 1350
YHMREEHGSE IVTWLAPSLP ALSPDLKDLF LEDKEVDLPN HFKTIGYVLR
1360 1370 1380 1390 1400
VDSTAFHYDT LDTYGAVDKT PLPLKGVVGN ELYLHEIPEK IVFHYESRND
1410 1420 1430 1440 1450
DCGMIMLCQI RGKMRVVGML VAGKDKTSWA DIMPPNSLAE LKSQIDYIPE
1460 1470 1480 1490 1500
FGEACDGYFK AGYVHKSEAP TLPKKTNMVP VPESLRVPCD VPVKEPAVLT
1510 1520 1530 1540 1550
KDDPRCPIGV DPPRAALKKK FTQPMMELEQ EILDEVATDI LETWYDCEDH
1560 1570 1580 1590 1600
VLSDISLSVA INGIPADSEE AELENFVMKT SPGYPYFKNN RAEKLKGKHA
1610 1620 1630 1640 1650
YFEEAEDGSL QLKKGGMAAE LHENLVEFTK NEVPELVVIE CTKDELLPER
1660 1670 1680 1690 1700
KIKVGACRLF EIMPLHYNLF LRQKTCAFTQ FLQHNRHRLP CQVGTNPYSR
1710 1720 1730 1740 1750
EWGHMLNRLM RPKTNEAINC DYSGFDGLLN PQLIECIARM INRLYALSGE
1760 1770 1780 1790 1800
SDVQQAQRYN MLMALVGRYA FVGQQVYKVN CGLPSGFALT VVVNSVFNEI
1810 1820 1830 1840 1850
LIRYAYKKLA PAPERNRFGS TVCLLVYGDD NLISVSPSIA SWFTGEAIRI
1860 1870 1880 1890 1900
TLAEKKVKIT DGSDKDAPTI EAKSFWELDF LKRKFLKLDN GIVQAPLDRS
1910 1920 1930 1940 1950
AIFSSLYWLT PDKSKFHESQ KPSDFQGEVD VIEELLLNVN VALMELYLHN
1960 1970 1980 1990 2000
DVAEFQRVRG FYAQRLPLMV SQLRTWAFCE AFHSAQQTGM QKYDPAVVLD
2010 2020 2030 2040 2050
HMSGVDFKRF MHMSEQGNKA HFYTEMLGVS GPHYKPQEGD FIVSNQPLKP
2060 2070 2080 2090 2100
GVQGEYVPIV FGEGIGGLPT KKWVGDFGKP SQLKNSKGYL ITGLLREQIE
2110 2120 2130 2140 2150
AGKRLIFMGP APYVANNAAL ISFGSAHKML IQKDALAHYR NVIPESTSGL
2160 2170 2180 2190 2200
EQYFDAPIPQ ASVGTFYFGD GETYTALCEY KDGKVLQYEG LPTAILNQAA
2210 2220 2230 2240 2250
KDRKVPCMVA RQWKSKFTVR MACDSNMCPH HSATCANFEL AFKQCWLSKC
2260
KCAGNNVSKW YGTKFS
Length:2,266
Mass (Da):254,131
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF27C55CBE738377
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY157993 Genomic RNA Translation: AAN72830.1

NCBI Reference Sequences

More...
RefSeqi
NP_958814.1, NC_004439.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
956643

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:956643

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157993 Genomic RNA Translation: AAN72830.1
RefSeqiNP_958814.1, NC_004439.1

3D structure databases

SMRiQ8B8X3
ModBaseiSearch...

Protein family/group databases

MEROPSiC03.025

Genome annotation databases

GeneIDi956643
KEGGivg:956643

Family and domain databases

Gene3Di3.30.70.270, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR044067, PCV_3C_PRO
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00680, RdRP_1, 1 hit
PF00910, RNA_helicase, 1 hit
SUPFAMiSSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51874, PCV_3C_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL1_TBRVM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8B8X3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: February 23, 2022
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again