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Entry version 53 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Major viral transcription factor ICP4 homolog

Gene

ORF62

more
Organism
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional transactivator. May interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. Negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis (By similarity).By similarity

Miscellaneous

Encoded both by ORF62 and ORF71 within the inverted repeat sequences bounding the Us region of the VZV genome.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major viral transcription factor ICP4 homolog
Alternative name(s):
Immediate-early protein 62
Short name:
IE62
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ORF62
AND
ORF Names:ORF71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVaricella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri341980 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008505 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000008504 Componenti: Genome
  • UP000002603 Componenti: Genome
  • UP000008506 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003854611 – 1310Major viral transcription factor ICP4 homologAdd BLAST1310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei686Phosphoserine; by VZV ORF66By similarity1
Modified residuei722Phosphoserine; by VZV ORF66By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ORF66 protein kinase on Ser-686 and Ser-722. Also phosphorylated by ORF47 protein kinase and by human CSNK2A1/CKII (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8AZM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Early protein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IE4 and IE63.

Interacts with human USF1 and SP1 (By similarity).

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8AZM1, 23 interactors

Molecular INTeraction database

More...
MINTi
Q8AZM1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8AZM1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi677 – 685Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 33Poly-Ala6
Compositional biasi353 – 360Poly-Ser8
Compositional biasi600 – 605Poly-Ala6
Compositional biasi1285 – 1290Poly-Ser6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae ICP4 family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005205, Herpes_ICP4_C
IPR005206, Herpes_ICP4_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03585, Herpes_ICP4_C, 1 hit
PF03584, Herpes_ICP4_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8AZM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTPPMQRST PQRAGSPDTL ELMDLLDAAA AAAEHRARVV TSSQPDDLLF
60 70 80 90 100
GENGVMVGRE HEIVSIPSVS GLQPEPRTED VGEELTQDDY VCEDGQDLMG
110 120 130 140 150
SPVIPLAEVF HTRFSEAGAR EPTGADRSLE TVSLGTKLAR SPKPPMNDGE
160 170 180 190 200
TGRGTTPPFP QAFSPVSPAS PVGDAAGNDQ REDQRSIPRQ TTRGNSPGLP
210 220 230 240 250
SVVHRDRQTQ SISGKKPGDE QAGHAHASGD GVVLQKTQRP AQGKSPKKKT
260 270 280 290 300
LKVKVPLPAR KPGGPVPGPV EQLYHVLSDS VPAKGAKADL PFETDDTRPR
310 320 330 340 350
KHDARGITPR VPGRSSGGKP RAFLALPGRS HAPDPIEDDS PVEKKPKSRE
360 370 380 390 400
FVSSSSSSSS WGSSSEDEDD EPRRVSVGSE TTGSRSGREH APSPSNSDDS
410 420 430 440 450
DSNDGGSTKQ NIQPGYRSIS GPDPRIRKTK RLAGEPGRQR QKSFSLPRSR
460 470 480 490 500
TPIIPPVSGP LMMPDGSPWP GSAPLPSNRV RFGPSGETRE GHWEDEAVRA
510 520 530 540 550
ARARYEASTE PVPLYVPELG DPARQYRALI NLIYCPDRDP IAWLQNPKLT
560 570 580 590 600
GVNSALNQFY QKLLPPGRAG TAVTGSVASP VPHVGEAMAT GEALWALPHA
610 620 630 640 650
AAAVAMSRRY DRAQKHFILQ SLRRAFASMA YPEATGSSPA ARISRGHPSP
660 670 680 690 700
TTPATQTPDP QPSAAARSLS VCPPDDRLRT PRKRKSQPVE SRSLLDKIRE
710 720 730 740 750
TPVADARVAD DHVVSKAKRR VSEPVTITSG PVVDPPAVIT MPLDGPAPNG
760 770 780 790 800
GFRRIPRGAL HTPVPSDQAR KAYCTPETIA RLVDDPLFPT AWRPALSFDP
810 820 830 840 850
GALAEIAARR PGGGDRRFGP PSGVEALRRR CAWMRQIPDP EDVRLLIIYD
860 870 880 890 900
PLPGEDINGP LESTLATDPG PSWSPSRGGL SVVLAALSNR LCLPSTHAWA
910 920 930 940 950
GNWTGPPDVS ALNARGVLLL STRDLAFAGA VEYLGSRLAS ARRRLLVLDA
960 970 980 990 1000
VALERWPRDG PALSQYHVYV RAPARPDAQA VVRWPDSAVT EGLARAVFAS
1010 1020 1030 1040 1050
SRTFGPASFA RIETAFANLY PGEQPLCLCR GGNVAYTVCT RAGPKTRVPL
1060 1070 1080 1090 1100
SPREYRQYVL PGFDGCKDLA RQSRGLGLGA ADFVDEAAHS HRAANRWGLG
1110 1120 1130 1140 1150
AALRPVFLPE GRRPGAAGPE AGDVPTWARV FCRHALLEPD PAAEPLVLPP
1160 1170 1180 1190 1200
VAGRSVALYA SADEARNALP PIPRVMWPPG FGAAETVLEG SDGTRFVFGH
1210 1220 1230 1240 1250
HGGSERPAET QAGRQRRTAD DREHALEPDD WEVGCEDAWD SEEGGGDDGD
1260 1270 1280 1290 1300
APGSSFGVSI VSVAPGVLRD RRVGLRPAVK VELLSSSSSS EDEDDVWGGR
1310
GGRSPPQSRG
Length:1,310
Mass (Da):139,996
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A0EF6D19515CAC0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti628S → G in strain: Oka varicella vaccine Biken (V-Oka-Biken), Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk). 1
Natural varianti958R → G in strain: Oka varicella vaccine Biken (V-Oka-Biken), Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk). 1
Natural varianti1197V → A in strain: Oka varicella vaccine Biken (V-Oka-Biken), Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk). 1
Natural varianti1260I → V in strain: Oka varicella vaccine Biken (V-Oka-Biken), Oka varicella vaccine VarilRix (V-Oka-GSK) and Oka varicella vaccine Varivax (V-Oka-Merk). 1
Natural varianti1275L → S in strain: Oka varicella vaccine Biken (V-Oka-Biken). 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF206304 Genomic DNA Translation: AAF61663.1
AY016449 Genomic DNA Translation: AAK19942.1
AB097932 Genomic DNA Translation: BAC44881.1
AB097933 Genomic DNA Translation: BAC44882.1
DQ008354 Genomic DNA Translation: AAY57671.1
DQ008354 Genomic DNA Translation: AAY57680.1
DQ008355 Genomic DNA Translation: AAY57742.1
DQ008355 Genomic DNA Translation: AAY57751.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206304 Genomic DNA Translation: AAF61663.1
AY016449 Genomic DNA Translation: AAK19942.1
AB097932 Genomic DNA Translation: BAC44881.1
AB097933 Genomic DNA Translation: BAC44882.1
DQ008354 Genomic DNA Translation: AAY57671.1
DQ008354 Genomic DNA Translation: AAY57680.1
DQ008355 Genomic DNA Translation: AAY57742.1
DQ008355 Genomic DNA Translation: AAY57751.1

3D structure databases

SMRiQ8AZM1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8AZM1, 23 interactors
MINTiQ8AZM1

Proteomic databases

PRIDEiQ8AZM1

Family and domain databases

InterProiView protein in InterPro
IPR005205, Herpes_ICP4_C
IPR005206, Herpes_ICP4_N
PfamiView protein in Pfam
PF03585, Herpes_ICP4_C, 1 hit
PF03584, Herpes_ICP4_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICP4_VZVO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8AZM1
Secondary accession number(s): Q4JQQ4
, Q4JQR3, Q4JQX5, Q8AZM2, Q98WV6, Q9J3N0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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