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Entry version 114 (26 Feb 2020)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Neogenin

Gene

neo1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NeogeninImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:neo1aImported
Synonyms:neo1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-021031-1 neo1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1080 – 1105HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500430563823 – 1428Sequence analysisAdd BLAST1406

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
B0CM042EBI-2268182,EBI-2268080

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8AY67, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8AY67

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 126Ig-likeInterPro annotationAdd BLAST94
Domaini139 – 219Ig-likeInterPro annotationAdd BLAST81
Domaini244 – 316Ig-likeInterPro annotationAdd BLAST73
Domaini321 – 406Ig-likeInterPro annotationAdd BLAST86
Domaini422 – 515Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini521 – 611Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini616 – 710Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini717 – 810Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini838 – 934Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini939 – 1036Fibronectin type-IIIInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1033 – 1072DisorderedSequence analysisAdd BLAST40
Regioni1115 – 1137DisorderedSequence analysisAdd BLAST23
Regioni1151 – 1182DisorderedSequence analysisAdd BLAST32
Regioni1252 – 1298DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1405 – 1425Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4221 Eukaryota
ENOG410Z913 LUCA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8AY67

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033024 Neogenin
IPR010560 Neogenin_C

The PANTHER Classification System

More...
PANTHERi
PTHR44170:SF14 PTHR44170:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 2 hits
PF13895 Ig_2, 1 hit
PF06583 Neogenin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8AY67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERGARLLL SLFCLTITVS HAEKGSAVRN FSPFWFSTEP SDTLAVRGAP
60 70 80 90 100
VLLNCSVHSE SPAKIEWKKD GSFLSLASDE RRHVLADGSL LISSVVHSKH
110 120 130 140 150
NKPDEGVYQC VATIDNLGTI ISRTARLNVA GIARFLSQPE MASVRVGDSQ
160 170 180 190 200
VLSCEVNPDL VSFIRWEQNK EAVELDHRVF SLPSGALVIS NATETDAGLY
210 220 230 240 250
RCVIDNAGPT KISEEAQLHI LTETGEERTL EFLQEPQHVS KLVGESVLLP
260 270 280 290 300
CVVTGYPTPE ITWMYKDQLI EDSSGRFEIL GGGSLRIFNL TEEDAGVYNC
310 320 330 340 350
LAENTNGSIE AQAELTLKDS PQFLKKPVNV FAHEATDVIF ECEVSGSPSP
360 370 380 390 400
TIKWVKNGDA VIPSDYFKII KEQNLQVLGL VKSDEGFYQC LAENDAGNVQ
410 420 430 440 450
SSAQLVILDQ GSRGGAGPTP SAPRDVVASL VSTRFLKLTW RLPAEPHGDD
460 470 480 490 500
VTYSVYYSLE GTNRERIVNT SRPGEMQVTI QNLMPDTKYA FRVVAHNKNG
510 520 530 540 550
PGESSVPLKV ETQPEVQVPG PAPNLHAVVM SPSTVSLSWD VPLIGNGEIQ
560 570 580 590 600
NYKIYYMEKG MDSEQDLDVN TLSYTMTGLK KFTEYSFRLV AYNKHGPGVS
610 620 630 640 650
TEDISVRTYS DVPSSPPQNM TVEVLNSKSL MIRWQPPPAD AQNGEITGYK
660 670 680 690 700
IRYRKGTRKS EVAEITSGSQ LYQLIDGLQR GTEYMLRVSA MTVNGTGPAT
710 720 730 740 750
DWTTAETFES DLDESRVPDV PSSLHVRSLV NSIVVSWTPP ENQDIVVRGY
760 770 780 790 800
SISYGIGSPH AQTIKVDYKQ RYYTIENLNP NSHYVITLKA FNNVGEGIPV
810 820 830 840 850
YESAITRPQS DPIDPDVDLY ELFHAPYTPV PDPIPMLPPV GVQASVLNQD
860 870 880 890 900
TIKVTWADNS LPKNQKITDA RYYTVRWKTN IPANTKFKVA NTTTLFHTVT
910 920 930 940 950
GLKPNTLYEF SVMVTKGRRT STWSMTAHGT TFESIPSSPP KDVTVVSKEG
960 970 980 990 1000
RPKTIIVNWQ PPSEANGKIT GYIIYYSTDV KAEVHDWVIE PVVGNRLTHQ
1010 1020 1030 1040 1050
IQELTLDTTY YFKIQARNSK GMGPMSEAVQ FRTPKAESSD KMANDQAPGI
1060 1070 1080 1090 1100
SVKQGRPSAP DNGFGSPGKP DMSGTGDNHI LVIVIIVSVG AFTIIVVVVG
1110 1120 1130 1140 1150
AFLCTRRTTT QQKKKRAACK SANGSHKYKG NSKDLKPPDL WIHHERLELK
1160 1170 1180 1190 1200
PIDKSPEPNP VMTDTPIPRT SQDITPVDGS MDPMLQRRNS YRGHESEDSM
1210 1220 1230 1240 1250
STLAGRRGMR PKMMMPFDAQ PPQPVISAHP IHSLDNHHHH YHLGSLASPT
1260 1270 1280 1290 1300
RSYLHHQSST RSIATPISHL DRAESTESVR NTPNAELLPP SGQPSCTTDL
1310 1320 1330 1340 1350
SETDISFHSS AAEEEPAFAT PTAHVRPTHP LKSFAVPAIP AHAMYDSAAL
1360 1370 1380 1390 1400
PSTPLLSQTG PHSVKTASIG TLGRTRTPMP VIVPNAPDVS EGCRLHEDAG
1410 1420
SNYETDELSE EMAHLEGLMK DLNAITTA
Length:1,428
Mass (Da):156,821
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4B0441197871279
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY029280 mRNA Translation: AAK33004.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029280 mRNA Translation: AAK33004.1

3D structure databases

SMRiQ8AY67
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8AY67, 1 interactor

Organism-specific databases

ZFINiZDB-GENE-021031-1 neo1a

Phylogenomic databases

eggNOGiKOG4221 Eukaryota
ENOG410Z913 LUCA
PhylomeDBiQ8AY67

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033024 Neogenin
IPR010560 Neogenin_C
PANTHERiPTHR44170:SF14 PTHR44170:SF14, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 2 hits
PF13895 Ig_2, 1 hit
PF06583 Neogenin_C, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8AY67_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8AY67
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 26, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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