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UniProtKB - Q8AY27 (Q8AY27_XENLA)
Protein
Submitted name:
Checkpoint protein
Gene
rad1.L
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
GO - Molecular functioni
- 3'-5' exonuclease activity Source: UniProtKB
GO - Biological processi
- DNA damage checkpoint signaling Source: InterPro
- DNA repair Source: UniProtKB-KW
Keywordsi
Molecular function | ExonucleaseImported, Hydrolase, Nuclease |
Biological process | DNA damage, DNA repairARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Checkpoint proteinImportedSubmitted name: PCNA-like DNA checkpoint protein Rad1ImportedSubmitted name: RAD1 checkpoint DNA exonuclease L homeologImported (EC:3.1.11.2Imported) |
Gene namesi | |
Organismi | Xenopus laevis (African clawed frog)Imported |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-979334, rad1.L |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusARBA annotationStructurei
Family & Domainsi
Sequence similaritiesi
Belongs to the rad1 family.ARBA annotation
Phylogenomic databases
OrthoDBi | 1440961at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003011, Cell_cycle_checkpoint_Rad1 IPR003021, Rad1_Rec1_Rad17 |
PANTHERi | PTHR10870, PTHR10870, 1 hit |
Pfami | View protein in Pfam PF02144, Rad1, 1 hit |
PRINTSi | PR01245, RAD1REC1 PR01246, RAD1REPAIR |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8AY27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPFLTQPEAD DDQYVLTCSL DNVRNLSNIL KAIHFKDHAS CFATNNGLKV
60 70 80 90 100
TVENAKCLQA NAFIQAGIFQ EFNIREESVV FRVNLTVLLD CLTIFGASAG
110 120 130 140 150
PGTPTALKMC YQGYGHPLIL FLEEGGVVTV CKINTQEPEE TLDFDFCSTN
160 170 180 190 200
VLNKIILQSE GLREAFAELD MTSEFLQIIM SPDKPYFRLS TFGNAGSAHL
210 220 230 240 250
DYPKDSDLIE AFHCTQTQTN RYKISLLKPS TKALALSCKV SIRTDNRGFL
260 270 280
SLQYMIRNED GQICFVEYYC CPDEEVGEAD V
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1L8I2M6 | A0A1L8I2M6_XENLA | RAD1 checkpoint DNA exonuclease L h... | rad1.L rad1, XRad1, XELAEV_18008373mg | 283 | Annotation score: | ||
A0A8J0U0T0 | A0A8J0U0T0_XENLA | RAD1 checkpoint DNA exonuclease L h... | rad1.L rad1, XRad1 | 309 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY126669 mRNA Translation: AAM95597.1 AY253233 mRNA Translation: AAP13341.1 |
RefSeqi | NP_001082324.1, NM_001088855.1 |
Genome annotation databases
GeneIDi | 398405 |
KEGGi | xla:398405 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY126669 mRNA Translation: AAM95597.1 AY253233 mRNA Translation: AAP13341.1 |
RefSeqi | NP_001082324.1, NM_001088855.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 398405 |
KEGGi | xla:398405 |
Organism-specific databases
CTDi | 398405 |
Xenbasei | XB-GENE-979334, rad1.L |
Phylogenomic databases
OrthoDBi | 1440961at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003011, Cell_cycle_checkpoint_Rad1 IPR003021, Rad1_Rec1_Rad17 |
PANTHERi | PTHR10870, PTHR10870, 1 hit |
Pfami | View protein in Pfam PF02144, Rad1, 1 hit |
PRINTSi | PR01245, RAD1REC1 PR01246, RAD1REPAIR |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8AY27_XENLA | |
Accessioni | Q8AY27Primary (citable) accession number: Q8AY27 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |