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UniProtKB - Q8AY12 (Q8AY12_DANRE)
Protein
Submitted name:
Interferon
Gene
ifnphi1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: InterPro
- type I interferon receptor binding Source: InterPro
GO - Biological processi
- defense response to bacterium Source: ZFIN
- defense response to virus Source: ZFIN
- regulation of defense response to virus by host Source: ZFIN
- response to arsenic-containing substance Source: ZFIN
- response to exogenous dsRNA Source: ZFIN
- response to virus Source: ZFIN
Keywordsi
Biological process | Antiviral defenseARBA annotation |
Enzyme and pathway databases
Reactomei | R-DRE-909733, Interferon alpha/beta signaling R-DRE-912694, Regulation of IFNA signaling |
Names & Taxonomyi
Protein namesi | Submitted name: InterferonImportedSubmitted name: Interferon phi 1 |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030721-3, ifnphi1 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5015099009 | 23 – 185 | Sequence analysisAdd BLAST | 163 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 120 | Combined sources |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000025607, Expressed in swim bladder and 24 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: InterPro
- type I interferon receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000034643 |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00510000050089 |
OMAi | HNKQALG |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta IPR015588, Interferon_beta |
PANTHERi | PTHR11691, PTHR11691, 1 hit PTHR11691:SF68, PTHR11691:SF68, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8AY12-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTQMWTYIF VIYVILQSQS SASTCEWLGR YRIITTESLN LLKNMGGKYA
60 70 80 90 100
DLETPFPSRL YTLMDKSKVE DQVKFLVLTL DHIIHLMDAR EHMNSVNWDQ
110 120 130 140 150
NTVEDFLNIL HRKSSDLKEC VARYAKPAHK ESYEIRIKRH FRTLKKILKK
160 170 180
KQYSAEAWEQ IRRVVKSHLQ RMDIIASNAR VNPRV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0FJI5 | A0FJI5_DANRE | Interferon phi 1 | ifnphi1 ifn, ifn1 | 141 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005440 Genomic DNA No translation available. BX908793 Genomic DNA No translation available. AY135716 mRNA Translation: AAM95448.1 |
Genome annotation databases
Ensembli | ENSDART00000029849.7; ENSDARP00000033132.5; ENSDARG00000025607.9 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005440 Genomic DNA No translation available. BX908793 Genomic DNA No translation available. AY135716 mRNA Translation: AAM95448.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PIV | X-ray | 2.09 | A/B | 23-185 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000034643 |
Genome annotation databases
Ensembli | ENSDART00000029849.7; ENSDARP00000033132.5; ENSDARG00000025607.9 |
Organism-specific databases
ZFINi | ZDB-GENE-030721-3, ifnphi1 |
Phylogenomic databases
GeneTreei | ENSGT00510000050089 |
OMAi | HNKQALG |
Enzyme and pathway databases
Reactomei | R-DRE-909733, Interferon alpha/beta signaling R-DRE-912694, Regulation of IFNA signaling |
Gene expression databases
Bgeei | ENSDARG00000025607, Expressed in swim bladder and 24 other tissues |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta IPR015588, Interferon_beta |
PANTHERi | PTHR11691, PTHR11691, 1 hit PTHR11691:SF68, PTHR11691:SF68, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8AY12_DANRE | |
Accessioni | Q8AY12Primary (citable) accession number: Q8AY12 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |