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Protein

Transcription factor Sox-10

Gene

sox10

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox9 to induce neural crest progenitors. Acts downstream of wnt-signaling at the neural plate border. Involved in the specification of neural crest progenitors fated to form the pigment cell lineage.3 Publications

Caution

Although PubMed:12812785 report induction by snai2/slug, PubMed:12885557 report that sox10 lies in between snai1/snail and snai2/slug in the complex sequence of inductive events required for neural crest formation.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi98 – 166HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity Source: UniProtKB
  • enzyme binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sox-10Imported
Alternative name(s):
SRY (sex determining region Y)-box 10
Gene namesi
Name:sox10
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865362 sox10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Loss of neural crest precursors. Also an increase in apoptosis and a decrease in cell proliferation in the neural fold.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52K → R: Eliminates one of two sumoylated products. Abolishes interaction with sumoylation factors. 1 Publication1
Mutagenesisi341K → R: Eliminates one of two sumoylated products. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003768611 – 446Transcription factor Sox-10Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki341Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Expressioni

Tissue specificityi

First expressed at stages 13/14 at the lateral edges of the neural plate, in the neural crest forming region. By stage 22, neural crest cells migrate in the cranial region and strong expression is seen in the crest cells that populate the branchial arches as well as those migrating in the frontonasal region. Also strongly expressed in the trunk neural crest. Expression in the otic vesicle begins around stage 25 and persists until at least stage 40. At stage 30, expression is down-regulated in the cranial neural crest of the pharyngeal arches but persists in the trunk neural crest, in the otic vesicle and in discrete domains adjacent to the hindbrain. At stage 40, expression is restricted to the otic vesicle, differentiated pigment cells, and in several cranial ganglia.2 Publications

Inductioni

By sox8, sox9 and snai1/snail, wnt-signaling and fgf-signaling in the neural crest-forming region.3 Publications

Interactioni

Subunit structurei

Interacts with the sumoylation factors ube2i/ubc9 and sumo1.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8AXX8
SMRiQ8AXX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 42Poly-AspSequence analysis7
Compositional biasi43 – 48Poly-GluSequence analysis6

Phylogenomic databases

KOiK09270

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022151 Sox_N
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12444 Sox_N, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8AXX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDQSLSEV EMSPVGSEDP SLTPDPLPPH AHSSPDDDDD DDEEEEEETK
60 70 80 90 100
VKKEQDSEDE RFPVCIREAV SQVLNGYDWT LVPMPVRVNG GSKSKPHVKR
110 120 130 140 150
PMNAFMVWAQ AARRKLADQY PHLHNAELSK TLGKLWRLLN ENDKRPFIEE
160 170 180 190 200
AERLRMQHKK DHPDYKYQPR RRKNGKPSPG EGDGSSEAEG GAASIQAHYK
210 220 230 240 250
NSHLDHRHGS PMSDGNSEHS TGQSHGPPTP PTTPKTELQA GKSDGKRDGS
260 270 280 290 300
HALREGGKPQ IDFGNVDIGE ISHDVMSNME TFDVNEFDQY LPPNGHAGHP
310 320 330 340 350
SHIGGYTSSY GLTGALAAGP SAWALAKQHS QTVADSKAQV KTESSSTSHY
360 370 380 390 400
TEQPSTSQLT YTSLGLPHYG SAFPSISRPQ FDYADHQPSS SYYSHSAQAS
410 420 430 440
SLYSAFSYMG PPQRPLYTAI SDPPSVAQSH SPTHWEQPVY TTLSRP
Length:446
Mass (Da):49,098
Last modified:March 1, 2003 - v1
Checksum:iB7F13C68F2854443
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36D → DDD in AAI70062 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149116 mRNA Translation: AAN62483.1
AY157667 mRNA Translation: AAO13216.1
BC170062 mRNA Translation: AAI70062.1
RefSeqiNP_001082358.1, NM_001088889.1
XP_018112033.1, XM_018256544.1
UniGeneiXl.1588

Genome annotation databases

GeneIDi398422
KEGGixla:398422

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149116 mRNA Translation: AAN62483.1
AY157667 mRNA Translation: AAO13216.1
BC170062 mRNA Translation: AAI70062.1
RefSeqiNP_001082358.1, NM_001088889.1
XP_018112033.1, XM_018256544.1
UniGeneiXl.1588

3D structure databases

ProteinModelPortaliQ8AXX8
SMRiQ8AXX8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398422
KEGGixla:398422

Organism-specific databases

CTDi398422
XenbaseiXB-GENE-865362 sox10

Phylogenomic databases

KOiK09270

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022151 Sox_N
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12444 Sox_N, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX10_XENLA
AccessioniPrimary (citable) accession number: Q8AXX8
Secondary accession number(s): B7ZR69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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