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Entry version 115 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Neurogenic locus notch homolog protein 1

Gene

Notch-1

Organism
Cynops pyrrhogaster (Japanese fire-bellied newt) (Molge pyrrhogaster)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi431Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi434Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi451Calcium 2UniRule annotation1
Metal bindingi452Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi454Calcium 2UniRule annotation1
Metal bindingi468Calcium 2UniRule annotation1
Metal bindingi469Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi489Calcium 3UniRule annotation1
Metal bindingi490Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi492Calcium 3UniRule annotation1
Metal bindingi506Calcium 3UniRule annotation1
Metal bindingi507Calcium 3; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, Developmental proteinARBA annotation, ReceptorImported
Biological processAngiogenesisARBA annotation, DifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurogenic locus notch homolog protein 1ARBA annotation
Alternative name(s):
Notch 1 extracellular truncationARBA annotation
Notch 1 intracellular domainARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Notch-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCynops pyrrhogaster (Japanese fire-bellied newt) (Molge pyrrhogaster)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8330 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaeCynops

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1732 – 1753HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500430369520 – 2528Neurogenic locus notch homolog protein 1Sequence analysisAdd BLAST2509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi89 ↔ 98PROSITE-ProRule annotation
Disulfide bondi111 ↔ 128PROSITE-ProRule annotation
Disulfide bondi130 ↔ 139PROSITE-ProRule annotation
Disulfide bondi167 ↔ 176PROSITE-ProRule annotation
Disulfide bondi205 ↔ 214PROSITE-ProRule annotation
Disulfide bondi244 ↔ 253PROSITE-ProRule annotation
Disulfide bondi282 ↔ 291PROSITE-ProRule annotation
Disulfide bondi322 ↔ 331PROSITE-ProRule annotation
Disulfide bondi360 ↔ 369PROSITE-ProRule annotation
Disulfide bondi380 ↔ 397PROSITE-ProRule annotation
Disulfide bondi399 ↔ 408PROSITE-ProRule annotation
Disulfide bondi415 ↔ 428UniRule annotation
Disulfide bondi422 ↔ 437UniRule annotation
Disulfide bondi439 ↔ 448UniRule annotation
Disulfide bondi455 ↔ 466UniRule annotation
Disulfide bondi460 ↔ 475UniRule annotation
Disulfide bondi477 ↔ 486UniRule annotation
Disulfide bondi493 ↔ 504UniRule annotation
Disulfide bondi498 ↔ 513UniRule annotation
Disulfide bondi515 ↔ 524UniRule annotation
Disulfide bondi553 ↔ 562PROSITE-ProRule annotation
Disulfide bondi569 ↔ 579PROSITE-ProRule annotation
Disulfide bondi590 ↔ 599PROSITE-ProRule annotation
Disulfide bondi628 ↔ 637PROSITE-ProRule annotation
Disulfide bondi644 ↔ 654PROSITE-ProRule annotation
Disulfide bondi665 ↔ 674PROSITE-ProRule annotation
Disulfide bondi703 ↔ 712PROSITE-ProRule annotation
Disulfide bondi719 ↔ 729PROSITE-ProRule annotation
Disulfide bondi740 ↔ 749PROSITE-ProRule annotation
Disulfide bondi778 ↔ 787PROSITE-ProRule annotation
Disulfide bondi816 ↔ 825PROSITE-ProRule annotation
Disulfide bondi837 ↔ 854PROSITE-ProRule annotation
Disulfide bondi856 ↔ 865PROSITE-ProRule annotation
Disulfide bondi894 ↔ 903PROSITE-ProRule annotation
Disulfide bondi932 ↔ 941PROSITE-ProRule annotation
Disulfide bondi970 ↔ 979PROSITE-ProRule annotation
Disulfide bondi1008 ↔ 1017PROSITE-ProRule annotation
Disulfide bondi1046 ↔ 1055PROSITE-ProRule annotation
Disulfide bondi1084 ↔ 1093PROSITE-ProRule annotation
Disulfide bondi1111 ↔ 1121PROSITE-ProRule annotation
Disulfide bondi1132 ↔ 1141PROSITE-ProRule annotation
Disulfide bondi1170 ↔ 1179PROSITE-ProRule annotation
Disulfide bondi1208 ↔ 1217PROSITE-ProRule annotation
Disulfide bondi1254 ↔ 1263PROSITE-ProRule annotation
Disulfide bondi1275 ↔ 1292PROSITE-ProRule annotation
Disulfide bondi1294 ↔ 1303PROSITE-ProRule annotation
Disulfide bondi1335 ↔ 1344PROSITE-ProRule annotation
Disulfide bondi1373 ↔ 1382PROSITE-ProRule annotation
Disulfide bondi1395 ↔ 1412PROSITE-ProRule annotation
Disulfide bondi1414 ↔ 1423PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 58EGF-likeInterPro annotationAdd BLAST41
Domaini59 – 99EGF-likeInterPro annotationAdd BLAST41
Domaini102 – 140EGF-likeInterPro annotationAdd BLAST39
Domaini141 – 177EGF-likeInterPro annotationAdd BLAST37
Domaini179 – 215EGF-likeInterPro annotationAdd BLAST37
Domaini217 – 254EGF-likeInterPro annotationAdd BLAST38
Domaini256 – 292EGF-likeInterPro annotationAdd BLAST37
Domaini294 – 332EGF-likeInterPro annotationAdd BLAST39
Domaini334 – 370EGF-likeInterPro annotationAdd BLAST37
Domaini371 – 409EGF-likeInterPro annotationAdd BLAST39
Domaini411 – 449EGF-likeInterPro annotationAdd BLAST39
Domaini451 – 487EGF-likeInterPro annotationAdd BLAST37
Domaini489 – 525EGF-likeInterPro annotationAdd BLAST37
Domaini527 – 563EGF-likeInterPro annotationAdd BLAST37
Domaini565 – 600EGF-likeInterPro annotationAdd BLAST36
Domaini602 – 638EGF-likeInterPro annotationAdd BLAST37
Domaini640 – 675EGF-likeInterPro annotationAdd BLAST36
Domaini677 – 713EGF-likeInterPro annotationAdd BLAST37
Domaini715 – 750EGF-likeInterPro annotationAdd BLAST36
Domaini752 – 788EGF-likeInterPro annotationAdd BLAST37
Domaini790 – 826EGF-likeInterPro annotationAdd BLAST37
Domaini828 – 866EGF-likeInterPro annotationAdd BLAST39
Domaini868 – 904EGF-likeInterPro annotationAdd BLAST37
Domaini906 – 942EGF-likeInterPro annotationAdd BLAST37
Domaini944 – 980EGF-likeInterPro annotationAdd BLAST37
Domaini982 – 1018EGF-likeInterPro annotationAdd BLAST37
Domaini1020 – 1056EGF-likeInterPro annotationAdd BLAST37
Domaini1058 – 1094EGF-likeInterPro annotationAdd BLAST37
Domaini1107 – 1142EGF-likeInterPro annotationAdd BLAST36
Domaini1144 – 1180EGF-likeInterPro annotationAdd BLAST37
Domaini1182 – 1218EGF-likeInterPro annotationAdd BLAST37
Domaini1220 – 1264EGF-likeInterPro annotationAdd BLAST45
Domaini1266 – 1304EGF-likeInterPro annotationAdd BLAST39
Domaini1306 – 1345EGF-likeInterPro annotationAdd BLAST40
Domaini1347 – 1383EGF-likeInterPro annotationAdd BLAST37
Domaini1386 – 1424EGF-likeInterPro annotationAdd BLAST39
Domaini1447 – 1487LNRInterPro annotationAdd BLAST41
Domaini1488 – 1525LNRInterPro annotationAdd BLAST38
Domaini1526 – 1569LNRInterPro annotationAdd BLAST44
Domaini1869 – 2110ANK_REP_REGIONInterPro annotationAdd BLAST242
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1924 – 1956ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1991 – 2023ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2024 – 2056ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2057 – 2089ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1776 – 1805DisorderedSequence analysisAdd BLAST30
Regioni2137 – 2198DisorderedSequence analysisAdd BLAST62
Regioni2456 – 2528DisorderedSequence analysisAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2374 – 2394Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2165 – 2182Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi2456 – 2518Polar residuesSequence analysisAdd BLAST63

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.ARBA annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022362, Notch_1
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF11936, DUF3454, 1 hit
PF00008, EGF, 24 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 2 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279, Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452, LNOTCHREPEAT
PR01984, NOTCH1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 36 hits
SM00179, EGF_CA, 33 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 7 hits
SSF90193, SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 23 hits
PS00022, EGF_1, 32 hits
PS01186, EGF_2, 27 hits
PS50026, EGF_3, 36 hits
PS01187, EGF_CA, 10 hits
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8AXP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIPGFAALL LTLPSLAPAL RCTLQSEKCM NGGKCEALPN GTSVCTCSSS
60 70 80 90 100
AFVGERCQYS NPCLSSPCRN SGTCQVDIRG NTVDYSCICR LGYSDKLCLT
110 120 130 140 150
PMDNVCLNNP CRNGGTCELL SSLTQHKCRC PPGWTGETCQ QADPCASNPC
160 170 180 190 200
GNGGQCVPFE AQYVCKCPPA YHGPTCKLDI NECTSVPCKN GGTCVNEVGS
210 220 230 240 250
YQCTCRPEYT GRNCENLYVP CYPSPCQNGG TCRQTGDTTY ECACLPGFDS
260 270 280 290 300
QNCEVNIDDC PGNTCKNGGT CVDGVNTYNC QCPPEWTGQY CTEDVDECQL
310 320 330 340 350
MPNACQNGGT CHNNHGGYNC VCVNGWTGED CSENIDDCAN AACHSGATCH
360 370 380 390 400
DRVASFYCEC PHGRTGLLCH LNDACISSPC NEGANCDTNP VNGKAICTCP
410 420 430 440 450
SGYMGPACIQ DVDECSLGAN PCEHAGRCLN TLGSFQCQCS PGYTGPRCEM
460 470 480 490 500
DVNECLSNPC KNDATCLDQI GEFHCICMPG YEGVFCQTNT DECASSPCLH
510 520 530 540 550
NGRCIDKINE FHCECPIGFN GPLCQYDIDE CASTPCKNGA KCLDGANSYT
560 570 580 590 600
CDCAEGYSGF HCETDIDECD PDPCHYGTCS DGIAGFTCHC EPGYTGHRCE
610 620 630 640 650
IDVNECQSMP CQNGGECQDR KNSYSCRCPK GTTGVNCEIN MDDCASSPCD
660 670 680 690 700
YGKCIDRING YECACEPGYT GIMCNINIDE CDSNPCHNGG TCKDGINGFT
710 720 730 740 750
CVCPQGYQDP TCLSEVNECN SNPCIHGRCH DGINGYRCDC DPGWSGTNCD
760 770 780 790 800
INNNECDSNP CMNGGTCKDM TSGYLCACRD GFSGPNCQTN INECASNPCL
810 820 830 840 850
NQGTCIDDVA GYNCNCLLPY TGPTCGEVLA PCSDNPCKNG GECGESEDYE
860 870 880 890 900
SFSCSCPAGW QGQTCEIDIN ECVKSPCRNG AVCQNTDGSY RCNCKAGYSG
910 920 930 940 950
RHCETDIDDC LPNPCHSGGS CSDGINAFFC NCLAGFRGPK CEEDINECAS
960 970 980 990 1000
NPCKNGANCT DCVNSYTCTC PSGFSGIHCE NNTPDCTESS CFNGGTCIDG
1010 1020 1030 1040 1050
INTFTCRCPA GFIGSYCEHD VNECDSKPCL NGGTCQDSYG TYKCTCPQGF
1060 1070 1080 1090 1100
TGMNCQNLVR WCESSPCKHG GKCWQTNNLY RCECNSGWTG LYCDVPSVSC
1110 1120 1130 1140 1150
EVAAKQQGVD VANLCRNSGL CEDTGNTHHC RCQAGYTGSY CEEQVDECSP
1160 1170 1180 1190 1200
NPCQNGATCT DYLGGYSCEC VAGYHGINCS QEINECQSHP CQNGGTCIDL
1210 1220 1230 1240 1250
VNTYKCSCPR GTQGVHCEIN VDDCNPFFDP VTHEPKCFNN GKCVDRVGGY
1260 1270 1280 1290 1300
NCNCLPGFVG ERCEGDVNEC LSNPCDPRGT QNCIQLVNDY RCECRQGYSG
1310 1320 1330 1340 1350
RRCNTVVDGC KGKPCRNGGT CSVASNTDRG FICKCPSGFD GAICQYDSRS
1360 1370 1380 1390 1400
CGNLPCLHGG SCVSILKTSQ CMCTAAYTGP QCQYPVSSPC NSSPCYNGGT
1410 1420 1430 1440 1450
CKFVPEAPFY QCMCPGKFNG LYCHILDYEF NGGVGQDIIP PEIEEQCEIP
1460 1470 1480 1490 1500
VCASSSGNKI CNTQCNNHAC GWDGGDCSLN FNDPWKNCTQ SLQCWKYFND
1510 1520 1530 1540 1550
GKCDSQCNNA GCLYDGFDCQ KVEVQCNPLY DQYCRDHFQD GHCDQGCNNA
1560 1570 1580 1590 1600
ECEWDGLDCS NNMPEKLADG TLVIVVLTPP ELLKNNSFNF LRELSRVLHT
1610 1620 1630 1640 1650
NVVFKKDSKG EYMIIPYYGS DEELTKHHIK RSTETWSDVS TNVFNKVKMS
1660 1670 1680 1690 1700
LYTSSNGRQR RELDQNEIKG SIVYLEIDNR QCFQSSLQCF QSATDVAAFL
1710 1720 1730 1740 1750
GALASHGNLN IPYKIEAVKS ETGEPSKGPP LYLMYVLVVA LVVLAFIGVG
1760 1770 1780 1790 1800
VLVSRKRHRE HGQLWFPEGF KVTETNKSKR RPPLGEDSVG LKPLKNSTDL
1810 1820 1830 1840 1850
MDDNQTEWGD EETLDSKRFR FEQEAMLPDM NDQTDRRQWT QQHLDAADLR
1860 1870 1880 1890 1900
ISSMAPTPPQ GEIDPDCLDV NVRGPDGFTP LMIASCSGGG LETGNSEEEE
1910 1920 1930 1940 1950
DASANVISDF LYQGANLHNQ TDRTGETALH LAARYARSDA AKRLLEASAN
1960 1970 1980 1990 2000
ANVQDNMGRT PLHAAVAADA QGVFQILIRN RATELDARMH DGTTPLILAA
2010 2020 2030 2040 2050
RLAVEGMVEE LINCHADVNA VDDLGKSALH WAAAVNNVDA AIVLLKNGAN
2060 2070 2080 2090 2100
KDMQDNKEET PLFLAAREGS YETGKVLLDH FANRDITDHM DRLPRDIAQE
2110 2120 2130 2140 2150
RMHHDIVRLL DEYNLVRSPQ MHNSLGAPTL SPQICSPSSY LSNMKPAAQG
2160 2170 2180 2190 2200
KKARKQSIKS NGCNGKESKD VKARRKKSQD GKNLLDSSGG LSPVDSLESP
2210 2220 2230 2240 2250
HGYISDVASP PLMTSPFQQS PSMALNLLPG MTDGHMTLNH HNLAGKQDMT
2260 2270 2280 2290 2300
MAGSNRMTFE PVPPRLSHLS VSSPSTVMSS GSLNFTVGGA PTMNGQCDWL
2310 2320 2330 2340 2350
SRLQNGMVSN QYSALRNNAQ SSAHQQAHSM MTSLQNGLPT TTLSQLMSYQ
2360 2370 2380 2390 2400
AMPNTRIGSQ PHLMQAQQLQ QIQQQNLQQQ IQQQQQTMQQ HHNSSSSANN
2410 2420 2430 2440 2450
HIGQVFLSND LTQADLQQMT SNSMAVHTIL PQDTQLLTSS LPSSLTQSIA
2460 2470 2480 2490 2500
TTQFLTPPSQ HSYSSPMDNT PSHQLQVSDH PFLTPSPESP DQWSSSSPHS
2510 2520
NISDWSEGIS SPPTSMQVQI AHIPEAFK
Length:2,528
Mass (Da):273,963
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F167D51F420D369
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB095016 mRNA Translation: BAC41349.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095016 mRNA Translation: BAC41349.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022362, Notch_1
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF11936, DUF3454, 1 hit
PF00008, EGF, 24 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 2 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PIRSFiPIRSF002279, Notch, 1 hit
PRINTSiPR01452, LNOTCHREPEAT
PR01984, NOTCH1
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 36 hits
SM00179, EGF_CA, 33 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 7 hits
SSF90193, SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 23 hits
PS00022, EGF_1, 32 hits
PS01186, EGF_2, 27 hits
PS50026, EGF_3, 36 hits
PS01187, EGF_CA, 10 hits
PS50258, LNR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8AXP0_CYNPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8AXP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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