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Entry version 133 (22 Apr 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Vascular endothelial growth factor receptor kdr-like

Gene

kdrl

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis.3 Publications

Caution

Was originally thought to be an ortholog of KDR, but PubMed:18516225 has shown that it represents a fourth vertebrate vascular endothelial growth factor receptor (VEGFR) that is not present in eutherian mammals (marsupials and placental mammals).Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei843ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1003Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi815 – 823ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processAngiogenesis, Differentiation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vascular endothelial growth factor receptor kdr-like (EC:2.7.10.1)
Alternative name(s):
Fetal liver kinase 1
Short name:
FLK-1
Kinase insert domain receptor-A
Kinase insert domain receptor-like
Protein-tyrosine kinase receptor flk-1
Vascular endothelial growth factor receptor 4
Short name:
VEGFR-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kdrl
Synonyms:flkImported, flk-1, flk11 Publication, flka, kdr, kdra, vegfr2, vegfr4, vegr2
ORF Names:si:ch211-276g21.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-000705-1 kdrl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 740ExtracellularSequence analysisAdd BLAST712
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei741 – 761HelicalSequence analysisAdd BLAST21
Topological domaini762 – 1302CytoplasmicSequence analysisAdd BLAST541

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi845L → R in y17; abolishes kinase activity and causes specific defects in artery development. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001677529 – 1302Vascular endothelial growth factor receptor kdr-likeAdd BLAST1274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 104PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineCurated1
Glycosylationi97N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi150 ↔ 199PROSITE-ProRule annotationBy similarity
Glycosylationi242N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi243 ↔ 302PROSITE-ProRule annotation
Glycosylationi265N-linked (GlcNAc...) asparagineCurated1
Glycosylationi291N-linked (GlcNAc...) asparagineCurated1
Glycosylationi326N-linked (GlcNAc...) asparagineCurated1
Glycosylationi370N-linked (GlcNAc...) asparagineCurated1
Glycosylationi380N-linked (GlcNAc...) asparagineCurated1
Glycosylationi408N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi444 ↔ 524PROSITE-ProRule annotation
Glycosylationi453N-linked (GlcNAc...) asparagineCurated1
Glycosylationi466N-linked (GlcNAc...) asparagineCurated1
Glycosylationi505N-linked (GlcNAc...) asparagineCurated1
Glycosylationi517N-linked (GlcNAc...) asparagineCurated1
Glycosylationi532N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi565 ↔ 618PROSITE-ProRule annotation
Glycosylationi607N-linked (GlcNAc...) asparagineCurated1
Glycosylationi611N-linked (GlcNAc...) asparagineCurated1
Glycosylationi630N-linked (GlcNAc...) asparagineCurated1
Glycosylationi648N-linked (GlcNAc...) asparagineCurated1
Glycosylationi655N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi664 ↔ 712PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1029Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1034Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1150Phosphotyrosine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated and activated by vegfaa and vegfab.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8AXB3

PRoteomics IDEntifications database

More...
PRIDEi
Q8AXB3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

First expressed in embryos between 5- and 7-somites. At 7 somites, expressed in discrete bilateral stripes both anteriorly and posteriorly, and in a transverse ectodermal stripe in the hindbrain. From 7-somites, expression seems to extend caudally from the head, and in both directions in the trunk region, until by 20-somites, expression is detected as a continuous band from the anterior head region to the tailbud. Concurrently, cells expressing kdrl in the mid- and posterior trunk regions converge medially. By 24 hours post-fertilization (hpf), expressed in all the endothelial cells lining the vasculature.5 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with isoform VEGF165 of vegfaa and isoform VEGF171 of vegfab.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8AXB3, 16 interactors

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000007209

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8AXB3

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 115Ig-like C2-type 1CuratedAdd BLAST82
Domaini143 – 206Ig-like C2-type 2CuratedAdd BLAST64
Domaini222 – 318Ig-like C2-type 3CuratedAdd BLAST97
Domaini326 – 412Ig-like C2-type 4CuratedAdd BLAST87
Domaini419 – 542Ig-like C2-type 5CuratedAdd BLAST124
Domaini545 – 636Ig-like C2-type 6CuratedAdd BLAST92
Domaini643 – 728Ig-like C2-type 7CuratedAdd BLAST86
Domaini809 – 1139Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST331

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0200 Eukaryota
COG0515 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8AXB3

KEGG Orthology (KO)

More...
KOi
K05096

Database of Orthologous Groups

More...
OrthoDBi
236292at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8AXB3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR041348 VEGFR-2_TMD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF17988 VEGFR-2_TMD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 6 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 6 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8AXB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPLKTSVKA FFTLHVLFSC ISHGLVEGSR LPDPQLLPDG DTHLQHVGGT
60 70 80 90 100
LTLICRGSTA LHWRLASRNV SSVRIESCEE RLHKHCSKLV IHNLRHNDTG
110 120 130 140 150
IYSCSHKKSS DHEVSTYVFV KDPHHPFVEA YSLPHPLFAY RNDPYFVVPC
160 170 180 190 200
RTTYPNQNVI LETQMNPMAD DVKRGVQWDP KKGFTVPLKP YDSYHLITCL
210 220 230 240 250
TRVDNAEFSS VYLLKRLTME IKNLAIEPER PRVLVGDTLI LNCSAETTYN
260 270 280 290 300
GRIHFEWEFH KERINRTHHF STTPVQLAQI MVMSKALIVP NVTMEDKGTY
310 320 330 340 350
TCTGSIEFKK LQMSTKVIVY EHPFLNVTHN KRKFTSTVEG RRVQFEPRVN
360 370 380 390 400
AVPAPDRVLW YKDGVAISEN STCYETAGYN LTIKQVRQKD AGIFTIALSN
410 420 430 440 450
QERGLYRNIS YKLEVRVKPK IFEEDVAPAG PQTFRYDQRH KLTCTAFGIP
460 470 480 490 500
MPNITWFWQP CDPSANLTEC KLYTDPLPIE NVDDHFPQNP IKDVNSKVGL
510 520 530 540 550
LKSKNRTIST LVVKTANVSG VYSCTARNEL GNRTMRIPFY VDDHPQPFEI
560 570 580 590 600
EPSTAVAGDD ITLTCRGTRY LYDRLTWYDP LGHKVPKDET TLRIEPYTIS
610 620 630 640 650
LSIKLPNVSR NHTLGYECQA LKINTNKVVN VTSALTIDER QGPWLMQNLT
660 670 680 690 700
NQDVNSSSTL TLACLAYGVP APFITWYKDK TPVTEGPGIT LKDDGTLIIE
710 720 730 740 750
RVKKDDEGIY ECRASNDGGE AKTSAVITVV GEDGKPNIEV IILVSTGAAA
760 770 780 790 800
TFLWIMLILF IRKLRKPSSA DLKTGYLSII MDPEQMPLDE QCDRLPYDSN
810 820 830 840 850
KWEFPQDRLR LGKTLGHGAF GKVVEASAFG IDKISTCKTV AVKMLKVGAT
860 870 880 890 900
NNEWRALMSE LKILIHIGHH LNVVNLLGAC TKRGGPLMII VEFCKYGNLS
910 920 930 940 950
NYLRSKRGDF VVYKSQDGKA VRSSSGCDLS ELIKRRLESV ASTGSSASSG
960 970 980 990 1000
FIEDKSYCDS EEEEEEQEDL YKKVLTLEDL ICYSFQVAKG MEFLASRKCI
1010 1020 1030 1040 1050
HRDLAARNIL LSENNVVKIC DFGLARDVYK DPDYVRKGDA RLPLKWMAPE
1060 1070 1080 1090 1100
AIFDKIYTTQ SDVWSFGVLM WEIFSLGASP YPGLHIDEEF CCRLKEGTRM
1110 1120 1130 1140 1150
KAPEYSSSEI YQTMLDCWHG EPSQRPTFTE LVERLGDLLQ ASVQQEGKHY
1160 1170 1180 1190 1200
IPINTALLTK ADPSNQSPTE ETSTRPVSLR DSGTAWNIKI RPESVKTFDE
1210 1220 1230 1240 1250
VILENGTNKI HEGGQSDSGI GLSSDDLKTL KRLESLARPR SFMSRAMKRK
1260 1270 1280 1290 1300
SKESVLLEGE MDKYPPLVPS LSLEDSSLDS EMECHSPPPD YNYVVRYSTP

PV
Length:1,302
Mass (Da):146,950
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB18BDCCB6F5430B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IIR3A0A0R4IIR3_DANRE
Vascular endothelial growth factor ...
kdrl
1,301Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10A → G in CAM73177 (PubMed:18296487).Curated1
Sequence conflicti49G → E in AAL16381 (PubMed:12086862).Curated1
Sequence conflicti240 – 243ILNC → HPSTA in AAF03237 (PubMed:9630750).Curated4
Sequence conflicti252R → W in AAF03237 (PubMed:9630750).Curated1
Sequence conflicti267T → P in AAL16381 (PubMed:12086862).Curated1
Sequence conflicti485Missing in AAL16381 (PubMed:12086862).Curated1
Sequence conflicti583H → Y in AAL16381 (PubMed:12086862).Curated1
Sequence conflicti622K → N in AAL16381 (PubMed:12086862).Curated1
Sequence conflicti622K → N in CAM73177 (PubMed:18296487).Curated1
Sequence conflicti622K → N in AAI29159 (Ref. 5) Curated1
Sequence conflicti622K → N in AAF03237 (PubMed:9630750).Curated1
Sequence conflicti1203L → R in AAB18415 (PubMed:9053314).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY056466 mRNA Translation: AAL16381.1
AF487829 mRNA Translation: AAN47136.1
CU458916 mRNA Translation: CAM73177.1
AL935131 Genomic DNA Translation: CAQ13438.1
BC129158 mRNA Translation: AAI29159.1
AF180354 mRNA Translation: AAF03237.1
U89515 mRNA Translation: AAB62405.1
U82383 mRNA Translation: AAB41042.1
U75995 mRNA Translation: AAB18415.1

NCBI Reference Sequences

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RefSeqi
NP_571547.1, NM_131472.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
796537

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dre:796537

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY056466 mRNA Translation: AAL16381.1
AF487829 mRNA Translation: AAN47136.1
CU458916 mRNA Translation: CAM73177.1
AL935131 Genomic DNA Translation: CAQ13438.1
BC129158 mRNA Translation: AAI29159.1
AF180354 mRNA Translation: AAF03237.1
U89515 mRNA Translation: AAB62405.1
U82383 mRNA Translation: AAB41042.1
U75995 mRNA Translation: AAB18415.1
RefSeqiNP_571547.1, NM_131472.1

3D structure databases

SMRiQ8AXB3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8AXB3, 16 interactors
STRINGi7955.ENSDARP00000007209

Proteomic databases

PaxDbiQ8AXB3
PRIDEiQ8AXB3

Genome annotation databases

GeneIDi796537
KEGGidre:796537

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
796537
ZFINiZDB-GENE-000705-1 kdrl

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
InParanoidiQ8AXB3
KOiK05096
OrthoDBi236292at2759
PhylomeDBiQ8AXB3

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8AXB3

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR041348 VEGFR-2_TMD
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF17988 VEGFR-2_TMD, 1 hit
SMARTiView protein in SMART
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 6 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVGFR4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8AXB3
Secondary accession number(s): A1L1P1
, B0R127, O42377, P79743, Q8UUW9, Q98891, Q9PTL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: April 22, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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