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Protein
Submitted name:

Sialidase (Neuraminidase)

Gene

BT_0455

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • exo-alpha-sialidase activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
BTHE:G13PU-5359-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH33 Glycoside Hydrolase Family 33

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sialidase (Neuraminidase)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:BT_0455Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri226186 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001414 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500430356023 – 544Sequence analysisAdd BLAST522

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8AAK9

PRoteomics IDEntifications database

More...
PRIDEi
Q8AAK9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
226186.BT_0455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8AAK9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8AAK9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 172BNR_assoc_NInterPro annotationAdd BLAST149
Domaini235 – 515SialidaseInterPro annotationAdd BLAST281

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105W5A Bacteria
COG4409 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8AAK9

KEGG Orthology (KO)

More...
KOi
K01186

Identification of Orthologs from Complete Genome Data

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OMAi
RAWWSSH

Database of Orthologous Groups

More...
OrthoDBi
POG091H0EBR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR029456 Sialidase_N
IPR036278 Sialidase_sf
IPR008377 Sialidase_trypan

The PANTHER Classification System

More...
PANTHERi
PTHR10628 PTHR10628, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13088 BNR_2, 1 hit
PF14873 BNR_assoc_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01803 TCSIALIDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50939 SSF50939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8AAK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRNHYLFTL ILLLGCSIFV KASDTVFVHQ TQIPILIERQ DNVLFYFRLD
60 70 80 90 100
AKESRMMDEI VLDFGKSVNL SDVQAVKLYY GGTEALQDKG KKRFAPVDYI
110 120 130 140 150
SSHRPGNTLA AIPSYSIKCA EALQPSAKVV LKSHYKLFPG INFFWISLQM
160 170 180 190 200
KPETSLFTKI SSELQSVKID GKEAICEERS PKDIIHRMAV GVRHAGDDGS
210 220 230 240 250
ASFRIPGLVT SNKGTLLGVY DVRYNSSVDL QEYVDVGLSR STDGGKTWEK
260 270 280 290 300
MRLPLSFGEY DGLPAAQNGV GDPSILVDTQ TNTIWVVAAW THGMGNQRAW
310 320 330 340 350
WSSHPGMDLY QTAQLVMAKS TDDGKTWSKP INITEQVKDP SWYFLLQGPG
360 370 380 390 400
RGITMSDGTL VFPTQFIDST RVPNAGIMYS KDRGKTWKMH NMARTNTTEA
410 420 430 440 450
QVVETEPGVL MLNMRDNRGG SRAVAITKDL GKTWTEHPSS RKALQEPVCM
460 470 480 490 500
ASLIHVEAED NVLDKDILLF SNPNTTRGRN HITIKASLDD GLTWLPEHQL
510 520 530 540
MLDEGEGWGY SCLTMIDRET IGILYESSAA HMTFQAVKLK DLIR
Length:544
Mass (Da):60,798
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D28598913230321
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO75562.1

NCBI Reference Sequences

More...
RefSeqi
NP_809368.1, NC_004663.1
WP_008766031.1, NC_004663.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAO75562; AAO75562; BT_0455

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1071627
31617371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bth:BT_0455

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|226186.12.peg.455

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO75562.1
RefSeqiNP_809368.1, NC_004663.1
WP_008766031.1, NC_004663.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BBWX-ray2.30A1-544[»]
ProteinModelPortaliQ8AAK9
SMRiQ8AAK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_0455

Protein family/group databases

CAZyiGH33 Glycoside Hydrolase Family 33

Proteomic databases

PaxDbiQ8AAK9
PRIDEiQ8AAK9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO75562; AAO75562; BT_0455
GeneIDi1071627
31617371
KEGGibth:BT_0455
PATRICifig|226186.12.peg.455

Phylogenomic databases

eggNOGiENOG4105W5A Bacteria
COG4409 LUCA
InParanoidiQ8AAK9
KOiK01186
OMAiRAWWSSH
OrthoDBiPOG091H0EBR

Enzyme and pathway databases

BioCyciBTHE:G13PU-5359-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR029456 Sialidase_N
IPR036278 Sialidase_sf
IPR008377 Sialidase_trypan
PANTHERiPTHR10628 PTHR10628, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
PF14873 BNR_assoc_N, 1 hit
PRINTSiPR01803 TCSIALIDASE
SUPFAMiSSF50939 SSF50939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8AAK9_BACTN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8AAK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: December 5, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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