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Entry version 129 (16 Jan 2019)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

Beta-mannosidase

Gene

BT_0458

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-mannosidase activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BTHE:G13PU-5362-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.25 709

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH2 Glycoside Hydrolase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Beta-mannosidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:BT_0458Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri226186 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001414 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB08158 2,4-DINITROPHENYL 2-DEOXY-2-FLUORO-BETA-D-MANNOPYRANOSIDE

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500430309726 – 864Sequence analysisAdd BLAST839

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8AAK6

PRoteomics IDEntifications database

More...
PRIDEi
Q8AAK6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
226186.BT_0458

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8AAK6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JE8X-ray1.70A/B24-864[»]
2VJXX-ray1.85A/B26-864[»]
2VL4X-ray1.90A/B26-864[»]
2VMFX-ray2.10A/B26-864[»]
2VO5X-ray2.30A/B26-864[»]
2VOTX-ray1.95A/B26-864[»]
2VQTX-ray2.10A/B26-864[»]
2VQUX-ray1.90A/B26-864[»]
2VR4X-ray1.80A/B26-864[»]
2WBKX-ray2.10A/B26-864[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8AAK6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8AAK6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8AAK6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini222 – 331Glyco_hydro_2InterPro annotationAdd BLAST110

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105D6I Bacteria
COG3250 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8AAK6

KEGG Orthology (KO)

More...
KOi
K01192

Identification of Orthologs from Complete Genome Data

More...
OMAi
KGHTMGA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006102 Glyco_hydro_2_Ig-like
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00703 Glyco_hydro_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49303 SSF49303, 3 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8AAK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILNLTGKIA PIACGLLCCC SMVYAQGNDT SEVMLLDTGW EFSQSGTEKW
60 70 80 90 100
MPATVPGTVH QDLISHELLP NPFYGMNEKK IQWVENEDWE YRTSFIVSEE
110 120 130 140 150
QLNRDGIQLI FEGLDTYADV YLNGSLLLKA DNMFVGYTLP VKSVLRKGEN
160 170 180 190 200
HLYIYFHSPI RQTLPQYASN GFNYPADNDH HEKHLSVFSR KAPYSYGWDW
210 220 230 240 250
GIRMVTSGVW RPVTLRFYDI ATISDYYVRQ LSLTDENARL SNELIVNQIV
260 270 280 290 300
PQKIPAEVRV NVSLNGTTVT EVKQQVTLQP GINHITLPAE VTNPVRWMPN
310 320 330 340 350
GWGTPTLYDF SAQIACGDRI VAEQSHRIGL RTIRVVNEKD KDGESFYFEV
360 370 380 390 400
NGIPMFAKGA NYIPQDALLP NVTTERYQTL FRDMKEANMN MVRIWGGGTY
410 420 430 440 450
ENNLFYDLAD ENGILVWQDF MFACTPYPSD PTFLKRVEAE AVYNIRRLRN
460 470 480 490 500
HASLAMWCGN NEILEALKYW GFEKKFTPEV YQGLMHGYDK LFRELLPSTV
510 520 530 540 550
KEFDSDRFYV HSSPYLANWG RPESWGTGDS HNWGVWYGKK PFESLDTDLP
560 570 580 590 600
RFMSEFGFQS FPEMKTIAAF AAPEDYQIES EVMNAHQKSS IGNSLIRTYM
610 620 630 640 650
ERDYIIPESF EDFVYVGLVL QGQGMRHGLE AHRRNRPYCM GTLYWQLNDS
660 670 680 690 700
WPVVSWSSID YYGNWKALHY QAKRAFAPVL INPIQQNDSL SVYLISDRLD
710 720 730 740 750
TMEQMTLEMK VVDFDGKTLG KKIQVHSLEV PANTSKCVYR AKLDGWLTPE
760 770 780 790 800
DCRRSFLKLI LKDKSGHQVA ESVHFFRKTK DLQLPPTSVS YQMKQTDGKC
810 820 830 840 850
ELTLFSSMLA KDIFIETPLQ GARYSDNFFD LLPGERKKVI ITSPRIKKGE
860
ELPVNIKHIR ETYK
Length:864
Mass (Da):99,506
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6EB7577A9E5EFA1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO75565.1

NCBI Reference Sequences

More...
RefSeqi
NP_809371.1, NC_004663.1
WP_011107276.1, NC_004663.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAO75565; AAO75565; BT_0458

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1071631

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bth:BT_0458

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|226186.12.peg.458

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO75565.1
RefSeqiNP_809371.1, NC_004663.1
WP_011107276.1, NC_004663.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JE8X-ray1.70A/B24-864[»]
2VJXX-ray1.85A/B26-864[»]
2VL4X-ray1.90A/B26-864[»]
2VMFX-ray2.10A/B26-864[»]
2VO5X-ray2.30A/B26-864[»]
2VOTX-ray1.95A/B26-864[»]
2VQTX-ray2.10A/B26-864[»]
2VQUX-ray1.90A/B26-864[»]
2VR4X-ray1.80A/B26-864[»]
2WBKX-ray2.10A/B26-864[»]
ProteinModelPortaliQ8AAK6
SMRiQ8AAK6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_0458

Chemistry databases

BindingDBiQ8AAK6
DrugBankiDB08158 2,4-DINITROPHENYL 2-DEOXY-2-FLUORO-BETA-D-MANNOPYRANOSIDE

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Proteomic databases

PaxDbiQ8AAK6
PRIDEiQ8AAK6

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1071631
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO75565; AAO75565; BT_0458
GeneIDi1071631
KEGGibth:BT_0458
PATRICifig|226186.12.peg.458

Phylogenomic databases

eggNOGiENOG4105D6I Bacteria
COG3250 LUCA
InParanoidiQ8AAK6
KOiK01192
OMAiKGHTMGA

Enzyme and pathway databases

BioCyciBTHE:G13PU-5362-MONOMER
BRENDAi3.2.1.25 709

Miscellaneous databases

EvolutionaryTraceiQ8AAK6

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006102 Glyco_hydro_2_Ig-like
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
SUPFAMiSSF49303 SSF49303, 3 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8AAK6_BACTN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8AAK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: January 16, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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