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Protein

UvrABC system protein C

Gene

uvrC

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciBTHE:G13PU-8233-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:BT_3266
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002274021 – 609UvrABC system protein CAdd BLAST609

Proteomic databases

PaxDbiQ8A2N9
PRIDEiQ8A2N9

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_3266

Structurei

3D structure databases

ProteinModelPortaliQ8A2N9
SMRiQ8A2N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 100GIY-YIGUniRule annotationAdd BLAST79
Domaini214 – 249UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII Bacteria
COG0322 LUCA
HOGENOMiHOG000279960
InParanoidiQ8A2N9
KOiK03703
OMAiLFPIRQC
OrthoDBiPOG091H01BS

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR010994 RuvA_2-like
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A2N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTEPEAKTN EYLRGIVANL PEKPGVYQYL NTEGTIIYVG KAKNLKKRVY
60 70 80 90 100
SYFSKEHEPG KTRVLVSKIA DIRYIVVNTE EDALLLENNL IKKYKPRYNV
110 120 130 140 150
LLKDDKTYPS ICVQNEYFPR IFRTRKIIKN GSSYYGPYSH LPSMYAVLDL
160 170 180 190 200
IKHLYPLRTC NLNLSPENIR AGKFKVCLEY HIKKCAGPCV GLQSHEDYLK
210 220 230 240 250
NIDEIKEILK GNTQDISRML VEKMQELANE MKFEEAQKIK EKYLLIENYR
260 270 280 290 300
SKSEVVSSVL HNIDVFSIEE DDSNSAFVNY LHITNGAINQ AFTFEYKKKL
310 320 330 340 350
NESKEELLTL GIIEMRERYK SHSREIIVPF ELDLELNNVV FTVPQRGDKK
360 370 380 390 400
KLLDLSILNV KQYKADRLKQ AEKLNPEQRS MRLLKEIQNE LHLDKPPLQI
410 420 430 440 450
ECFDNSNIQG SDAVAACVVF KKAKPSKKDY RKYNIKTVVG PDDYASMKEV
460 470 480 490 500
VRRRYQRAIE ENSPLPDLII TDGGKGQMEV VREVIEDELH LNIPIAGLAK
510 520 530 540 550
DNKHRTSELL FGFPAQTIGI KQQSSLFRLL TQIQDEVHRF AITFHRDKRS
560 570 580 590 600
KRQVASALDS IKGIGEKTKT ALLKEFKSVK RIKEASLEEI AKVIGEVKAQ

TVKKGLSNE
Length:609
Mass (Da):70,186
Last modified:June 1, 2003 - v1
Checksum:iD05444F98D5BB692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO78372.1
RefSeqiNP_812178.1, NC_004663.1
WP_011108727.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO78372; AAO78372; BT_3266
GeneIDi1075868
31619429
KEGGibth:BT_3266
PATRICifig|226186.12.peg.3331

Similar proteinsi

Entry informationi

Entry nameiUVRC_BACTN
AccessioniPrimary (citable) accession number: Q8A2N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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