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Entry version 120 (29 Sep 2021)
Sequence version 1 (01 Jun 2003)
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Protein

TonB-dependent receptor SusC

Gene

susC

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: starch degradation

This protein is involved in the pathway starch degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway starch degradation and in Glycan degradation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metallocarboxypeptidase activity Source: GO_Central
  • starch binding Source: MENGO

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCarbohydrate metabolism, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BTHE:G13PU-8670-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00153

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.14.6.1, the outer membrane receptor (omr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TonB-dependent receptor SusC
Alternative name(s):
Starch-utilization system protein C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:susC
Ordered Locus Names:BT_3702
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri226186 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001414 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abolished ability to grow on starch.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042588227 – 1003TonB-dependent receptor SusCAdd BLAST977

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8A1G1

PRoteomics IDEntifications database

More...
PRIDEi
Q8A1G1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By maltose.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SusD.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
226186.BT_3702

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1629, Bacteria
COG4206, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004317_0_2_10

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8A1G1

Identification of Orthologs from Complete Genome Data

More...
OMAi
TWEKTTT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.130.10, 1 hit
2.40.170.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008969, CarboxyPept-like_regulatory
IPR012910, Plug_dom
IPR037066, Plug_dom_sf
IPR023996, TonB-dep_OMP_SusC/RagA
IPR023997, TonB-dep_OMP_SusC/RagA_CS
IPR000531, TonB-dep_rcpt_b-brl
IPR036942, TonB_rcpt_b-brl_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07715, Plug, 1 hit
PF00593, TonB_dep_Rec, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464, SSF49464, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04056, OMP_RagA_SusC, 1 hit
TIGR04057, SusC_RagA_signa, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8A1G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKGNFMFKV LLMLIAGIFL SIDAFAQQIT VKGIVKDTTG EPVIGANVVV
60 70 80 90 100
KGTTTGTITD FDGNFQLSAK QGDIIVVSFI GYQPQELPVA AQMNVILKDD
110 120 130 140 150
TEILDEVVVI GYGQVKKNDM TGSVMAIKPD ELSKGITTNA QDMLSGKIAG
160 170 180 190 200
VSVISNDGTP GGGAQIRIRG GSSLNASNDP LIVIDGLAID NEGIKGMANG
210 220 230 240 250
LSMVNPADIE TLTVLKDASA TAIYGSRASN GVIIITTKKG KNGQAPSVSY
260 270 280 290 300
NGSVSFSKTQ KRYDVLSGDE YRAYANQLWG DKLPADLGTA NTDWQDQIFR
310 320 330 340 350
TAVSTDHHVS INGGFKNLPY RVSLGYTDDN GIVKTSNFRR FTASVNLAPS
360 370 380 390 400
FFEDHLKFNI NAKFMNGKNR YADTGAAIGG ALAIDPTRPV YSNEDPYQFT
410 420 430 440 450
GGYWQNINST TGFSNPDWKY TSNPNSPQNP LAALELKNDK ANSNDFVGNV
460 470 480 490 500
DVDYKFHFLP DLRLHASIGG EYAEGTQTTI VSPYSFGNNY YGWNGDVTQY
510 520 530 540 550
KYNLSYNIYV QYIKSLGAND FDIMVGGEEQ HFHRNGFEEG QGWDSYTQEP
560 570 580 590 600
HDAKLREQTA YATRNTLVSY FGRLNYSLLN RYLFTFTMRW DGSSRFSKDN
610 620 630 640 650
RWGTFPSLAL GWKIKEENFL KDVNVLSDLK LRLGWGITGQ QNIGDDFAYL
660 670 680 690 700
PLYVVNNEYA QYPFGDTYYS TSRPKAFNEN LKWEKTTTWN AGLDFGFLNG
710 720 730 740 750
RITGGIDGYF RKTDDLLNSV KIPVGTNFNA QMTQNIGSLE NYGMEFSINA
760 770 780 790 800
KPIVTKDFTW DLSYNITWNH NEITKLTGGD DSDYYVEAGD KISRGNNTKV
810 820 830 840 850
QAHKVGYAAN SFYVYQQVYD ENGKPIENMF VDRNGNGTID SGDKYIYKKP
860 870 880 890 900
AGDVLMGLTS KMQYKNFDFS FSLRASLNNY VYYDFLSNKA NVSTSGLFSN
910 920 930 940 950
NAYSNTSAEA VALGLSGQGD YMSDYFIHNA SFLRCDNITL GYSFQNLWKT
960 970 980 990 1000
QTYKGVGGRV YATVQNPFII SKYKGLDPEV KSGIDANPYP RAMTFLLGLS

LQF
Length:1,003
Mass (Da):111,144
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93C1A907E1CD813B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA95938 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti249S → T in AAA95938 (PubMed:8550519).Curated1
Sequence conflicti441A → G in AAA95938 (PubMed:8550519).Curated1
Sequence conflicti792I → ISRGNNTKVQAHKVGYAANS FYV in AAA95938 (PubMed:8550519).Curated1
Sequence conflicti915L → F in AAA95938 (PubMed:8550519).Curated1
Sequence conflicti920D → DY in AAA95938 (PubMed:8550519).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L49338 Genomic DNA Translation: AAA95938.1 Frameshift.
AE015928 Genomic DNA Translation: AAO78807.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC6027

NCBI Reference Sequences

More...
RefSeqi
NP_812613.1, NC_004663.1
WP_011108938.1, NC_004663.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAO78807; AAO78807; BT_3702

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bth:BT_3702

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|226186.12.peg.3762

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49338 Genomic DNA Translation: AAA95938.1 Frameshift.
AE015928 Genomic DNA Translation: AAO78807.1
PIRiJC6027
RefSeqiNP_812613.1, NC_004663.1
WP_011108938.1, NC_004663.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi226186.BT_3702

Protein family/group databases

TCDBi1.B.14.6.1, the outer membrane receptor (omr) family

Proteomic databases

PaxDbiQ8A1G1
PRIDEiQ8A1G1

Genome annotation databases

EnsemblBacteriaiAAO78807; AAO78807; BT_3702
KEGGibth:BT_3702
PATRICifig|226186.12.peg.3762

Phylogenomic databases

eggNOGiCOG1629, Bacteria
COG4206, Bacteria
HOGENOMiCLU_004317_0_2_10
InParanoidiQ8A1G1
OMAiTWEKTTT

Enzyme and pathway databases

UniPathwayiUPA00153
BioCyciBTHE:G13PU-8670-MONOMER

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR008969, CarboxyPept-like_regulatory
IPR012910, Plug_dom
IPR037066, Plug_dom_sf
IPR023996, TonB-dep_OMP_SusC/RagA
IPR023997, TonB-dep_OMP_SusC/RagA_CS
IPR000531, TonB-dep_rcpt_b-brl
IPR036942, TonB_rcpt_b-brl_sf
PfamiView protein in Pfam
PF07715, Plug, 1 hit
PF00593, TonB_dep_Rec, 1 hit
SUPFAMiSSF49464, SSF49464, 1 hit
TIGRFAMsiTIGR04056, OMP_RagA_SusC, 1 hit
TIGR04057, SusC_RagA_signa, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUSC_BACTN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8A1G1
Secondary accession number(s): Q45780
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: June 1, 2003
Last modified: September 29, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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