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Entry version 113 (26 Feb 2020)
Sequence version 1 (01 Jun 2003)
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Protein

Nitrous-oxide reductase

Gene

nosZ

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: nitrate reduction (denitrification)

This protein is involved in step 4 of the subpathway that synthesizes dinitrogen from nitrate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Nitrous-oxide reductase (nosZ)
This subpathway is part of the pathway nitrate reduction (denitrification), which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dinitrogen from nitrate, the pathway nitrate reduction (denitrification) and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi147Copper Z2By similarity1
Metal bindingi148Copper Z3By similarity1
Metal bindingi196Copper Z2By similarity1
Metal bindingi273Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi276Calcium 2By similarity1
Metal bindingi284Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi290Calcium 2By similarity1
Metal bindingi335Calcium 2By similarity1
Metal bindingi337Copper Z1By similarity1
Metal bindingi392Copper Z1By similarity1
Metal bindingi443Copper Z3By similarity1
Metal bindingi464Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi479Calcium 1By similarity1
Metal bindingi504Copper Z4By similarity1
Metal bindingi593Copper A1By similarity1
Metal bindingi628Copper A1By similarity1
Metal bindingi628Copper A2By similarity1
Metal bindingi630Copper A2; via carbonyl oxygenBy similarity1
Metal bindingi632Copper A1By similarity1
Metal bindingi632Copper A2By similarity1
Metal bindingi636Copper A2By similarity1
Metal bindingi639Copper A1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandCalcium, Copper, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BDIA224911:G1G3J-316-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.7.2.4 929

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00652;UER00709

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitrous-oxide reductase (EC:1.7.2.4)
Alternative name(s):
N(2)OR
N2O reductase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nosZ
Ordered Locus Names:blr0315
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224911 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002526 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 46Tat-type signalSequence analysisAdd BLAST46
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001982447 – 650Nitrous-oxide reductaseAdd BLAST604

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q89XJ6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224911.27348563

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q89XJ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni552 – 650COX2-likeAdd BLAST99

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NosZ family.Curated
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105EQJ Bacteria
COG4263 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016420_0_0_5

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q89XJ6

KEGG Orthology (KO)

More...
KOi
K00376

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQEMQGY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q89XJ6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.420, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00716 NosZ, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002429 CcO_II-like_C
IPR008972 Cupredoxin
IPR028096 EfeO_Cupredoxin
IPR011045 N2O_reductase_N
IPR023644 NO_Rdtase
IPR041114 Nos_propeller
IPR041142 NOS_propeller_2
IPR006311 TAT_signal
IPR015943 WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13473 Cupredoxin_1, 1 hit
PF18764 nos_propeller, 1 hit
PF18793 nos_propeller_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503 SSF49503, 1 hit
SSF50974 SSF50974, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04244 nitrous_NosZ_RR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50857 COX2_CUA, 1 hit
PS51318 TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q89XJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSDNIKGV SRRTLLGTTA AAAGVGLAGG AVVTKDGAGF VSTADAQTKS
60 70 80 90 100
AAPKAPPARP AVQKTEVAPG ELDEYYVFFS SGQSGEMRII GLPSMRELMR
110 120 130 140 150
VPVFNRCSAT GWGQTNESLK VLTEGMQPAT REFLKNRGGT FMNGDLHHPH
160 170 180 190 200
VSFTDGTYDG RYAFMNDKAN SRVARVRLDV MKCDKIIELP NQHTVHGLRL
210 220 230 240 250
QKYPRTGYVF CNGEDGVPLP NDGKVLDNPK EYHSIFTALD GDTMKVAWQV
260 270 280 290 300
MVSGNLDNVD SDYQGKYCFS TCYNAEEGVT LAEMTANEQD WVVIFNLKRI
310 320 330 340 350
EEAVKKGDFK EMNGVPVIDG RKGSPYTRYV PVSNNPHGMN TAPDGIHIVA
360 370 380 390 400
AGKLSPTVTV MDVRLFDQLF DDKIKPRDVV VAEPELGLGP LHTAYDGKGN
410 420 430 440 450
AYTTLFLDSQ VVKWNIDLAK RAFKGEKVDP IIQKLDVHYQ PGHNHSSMGQ
460 470 480 490 500
TKEADGKWLI SLNKFSKDRF LNVGPLKPEN DQLIDISGDQ MKLVHDGPSF
510 520 530 540 550
AEPHDATIVH RSKINPISIW DRADPMFADA VKQAKADGIN LEADSKIIRD
560 570 580 590 600
GNKVRVYMTS TAPAFGLEQF QVKQGDQVTV YITNIDAVED LTHGFCIVNY
610 620 630 640 650
GIQMEVAPMA TASVSFSADK AGVYWYYCSW FCHAMHMEMK GRMFVEPKSV
Length:650
Mass (Da):71,674
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B6C547D90501C5B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti367D → N in CAA05518 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ002531 Genomic DNA Translation: CAA05518.1
BA000040 Genomic DNA Translation: BAC45580.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T44660

NCBI Reference Sequences

More...
RefSeqi
NP_766955.1, NC_004463.1
WP_011083147.1, NZ_CP011360.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAC45580; BAC45580; BAC45580

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1052167

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bja:blr0315

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224911.44.peg.8839

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002531 Genomic DNA Translation: CAA05518.1
BA000040 Genomic DNA Translation: BAC45580.1
PIRiT44660
RefSeqiNP_766955.1, NC_004463.1
WP_011083147.1, NZ_CP011360.1

3D structure databases

SMRiQ89XJ6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224911.27348563

Proteomic databases

PRIDEiQ89XJ6

Genome annotation databases

EnsemblBacteriaiBAC45580; BAC45580; BAC45580
GeneIDi1052167
KEGGibja:blr0315
PATRICifig|224911.44.peg.8839

Phylogenomic databases

eggNOGiENOG4105EQJ Bacteria
COG4263 LUCA
HOGENOMiCLU_016420_0_0_5
InParanoidiQ89XJ6
KOiK00376
OMAiHQEMQGY
PhylomeDBiQ89XJ6

Enzyme and pathway databases

UniPathwayiUPA00652;UER00709
BioCyciBDIA224911:G1G3J-316-MONOMER
BRENDAi1.7.2.4 929

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.420, 1 hit
HAMAPiMF_00716 NosZ, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR008972 Cupredoxin
IPR028096 EfeO_Cupredoxin
IPR011045 N2O_reductase_N
IPR023644 NO_Rdtase
IPR041114 Nos_propeller
IPR041142 NOS_propeller_2
IPR006311 TAT_signal
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF13473 Cupredoxin_1, 1 hit
PF18764 nos_propeller, 1 hit
PF18793 nos_propeller_2, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF50974 SSF50974, 1 hit
TIGRFAMsiTIGR04244 nitrous_NosZ_RR, 1 hit
PROSITEiView protein in PROSITE
PS50857 COX2_CUA, 1 hit
PS51318 TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOSZ_BRADU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q89XJ6
Secondary accession number(s): O31382
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: February 26, 2020
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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