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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-459-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:bll0456
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134391 – 322Malate dehydrogenaseAdd BLAST322

Proteomic databases

PRIDEiQ89X59

Interactioni

Protein-protein interaction databases

STRINGi224911.bll0456

Structurei

3D structure databases

ProteinModelPortaliQ89X59
SMRiQ89X59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
InParanoidiQ89X59
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6
PhylomeDBiQ89X59

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q89X59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDKIALIG SGQIGGTLAH LIGLKELGDV VMFDIAEGVP QGKALDIAQS
60 70 80 90 100
SPVDGFDAHY TGANSYEALD NAKVCIVTAG VPRKPGMSRD DLLSINLKVM
110 120 130 140 150
EQVGAGIKKY APDAFVICIT NPLDAMVWAL QKASGLPHKK VVGMAGVLDS
160 170 180 190 200
ARFRYFLADE FNVSVEDVTA FVLGGHGDTM VPLVKYSTVA GIPLPDLVKM
210 220 230 240 250
GWTSQARLDE IVDRTRNGGA EIVNLLKTGS AFYAPAASAI AMAESYLRDK
260 270 280 290 300
KRVLPSAAYL NGEYGVKDMY VGVPVVIGSK GVERVVEIEL AGKDREAFDK
310 320
SVGAVQGLVD ACKKIAPDLL GR
Length:322
Mass (Da):34,125
Last modified:June 1, 2003 - v1
Checksum:i22CBBE4D72E8253A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA Translation: BAC45721.1
RefSeqiNP_767096.1, NC_004463.1
WP_008145224.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC45721; BAC45721; BAC45721
GeneIDi1048520
23258282
KEGGibja:bll0456
PATRICifig|224911.44.peg.8987

Similar proteinsi

Entry informationi

Entry nameiMDH_BRADU
AccessioniPrimary (citable) accession number: Q89X59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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