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Protein

ATP-dependent protease subunit HslV

Gene

hslV

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.UniRule annotation

Catalytic activityi

ATP-dependent cleavage of peptide bonds with broad specificity.UniRule annotation

Enzyme regulationi

Allosterically activated by HslU binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14UniRule annotation1
Metal bindingi168Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi171Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi174Sodium; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase, Protease, Threonine protease
LigandMetal-binding, Sodium

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-655-MONOMER

Protein family/group databases

MEROPSiT01.006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease subunit HslVUniRule annotation (EC:3.4.25.2UniRule annotation)
Gene namesi
Name:hslVUniRule annotation
Ordered Locus Names:bll0649
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480911 – 186ATP-dependent protease subunit HslVAdd BLAST186

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi224911.bll0649

Structurei

3D structure databases

ProteinModelPortaliQ89WM9
SMRiQ89WM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family. HslV subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108R5P Bacteria
COG5405 LUCA
HOGENOMiHOG000064533
InParanoidiQ89WM9
KOiK01419
OMAiIMKGNAR
OrthoDBiPOG091H024X
PhylomeDBiQ89WM9

Family and domain databases

CDDicd01913 protease_HslV, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00248 HslV, 1 hit
InterProiView protein in InterPro
IPR022281 ATP-dep_Prtase_HsIV_su
IPR029055 Ntn_hydrolases_N
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR32194 PTHR32194, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PIRSFiPIRSF039093 HslV, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03692 ATP_dep_HslV, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q89WM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDSQKSSPG WHGTTILTVR KGGKVVIGGD GQVSIGQTVI KSNAKKVRKL
60 70 80 90 100
GRGDVIGGFA GATADAFTLF ERLEAKLEQY PGQLTRAAVE LAKDWRTDRY
110 120 130 140 150
LRRLEAMMIV ADKDVSLVLT GTGDVLEPEA GVMAIGSGGN YALAAARALL
160 170 180
DTDKDAETIV RRSLDIAADI CVYTNRNVTI ESLATG
Length:186
Mass (Da):19,797
Last modified:June 1, 2003 - v1
Checksum:i60AE1F0271D9B269
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA Translation: BAC45914.1
RefSeqiNP_767289.1, NC_004463.1
WP_011083476.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC45914; BAC45914; BAC45914
GeneIDi1049357
KEGGibja:bll0649
PATRICifig|224911.44.peg.18

Similar proteinsi

Entry informationi

Entry nameiHSLV_BRADU
AccessioniPrimary (citable) accession number: Q89WM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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