Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Miscellaneous

Calcium ions stabilize the structure, and may inhibit FabG activity by obstructing access to the active site.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38NADPBy similarity1
Metal bindingi51Calcium 1; via carbonyl oxygen; shared with dimeric partnerBy similarity1
Metal bindingi54Calcium 1; via carbonyl oxygen; shared with dimeric partnerBy similarity1
Binding sitei87NADP; via carbonyl oxygenBy similarity1
Binding sitei139SubstrateBy similarity1
Metal bindingi146Calcium 2By similarity1
Active sitei152Proton acceptorPROSITE-ProRule annotation1
Binding sitei185NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi234Calcium 3; shared with dimeric partnerBy similarity1
Metal bindingi235Calcium 3; via carbonyl oxygen; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADPBy similarity4
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi152 – 156NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandCalcium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciBAPH224915:G1G09-324-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:bbp_321
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546681 – 2453-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST245

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi224915.bbp321

Structurei

3D structure databases

ProteinModelPortaliQ89AG9
SMRiQ89AG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
KOiK00059
OMAiAVFQSPC
OrthoDBiPOG091H012M

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q89AG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTTKKIAVI TGANRGLGKG IAEELSNTNN ITVIGTSTSQ KGCKIINKYL
60 70 80 90 100
KNNGIGIKLD ITNPNEITKT MDFVYKNFGR VDILINNAGI IRDKLLINMK
110 120 130 140 150
TQDWNSVLNV NLNSIFYMSK SVIRNMIKNK QGKIITIGSV IAHIGNCGQT
160 170 180 190 200
NYSAAKLGLV GFHKSLALEL APKGITVNMI APGLIKTGMT NNLSQKQLSK
210 220 230 240
YLSKIPMKRL GTIKEISKIT LFLISNDANY ITGQVIHVNG GMYMP
Length:245
Mass (Da):26,788
Last modified:May 30, 2003 - v1
Checksum:i6B94C5520D69157E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA Translation: AAO27043.1
RefSeqiWP_011091444.1, NC_004545.1

Genome annotation databases

EnsemblBacteriaiAAO27043; AAO27043; bbp_321
KEGGibab:bbp_321

Similar proteinsi

Entry informationi

Entry nameiFABG_BUCBP
AccessioniPrimary (citable) accession number: Q89AG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health