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Entry version 73 (03 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Nucleoprotein

Gene

N

Organism
Measles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein
Biological processHost-virus interaction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NP
Short name:
Protein N
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:N
Synonyms:NP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMeasles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri70146 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaHaploviricotinaMonjiviricetesMononegaviralesParamyxoviridaeOrthoparamyxovirinaeMorbillivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001426551 – 525NucleoproteinAdd BLAST525

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, binds the P protein and thereby positions the polymerase on the template.

Interacts with human FCGR2B protein.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P/VP034223EBI-8589867,EBI-8589851From Measles virus (strain Edmonston).

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q89933, 1 interactor

Molecular INTeraction database

More...
MINTi
Q89933

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1525
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q89933

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 400NcoreAdd BLAST400
Regioni1 – 375HomomultimerizationBy similarityAdd BLAST375
Regioni401 – 525NtailAdd BLAST125
Regioni477 – 505P protein-bindingBy similarityAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Ncore is globular and carries regions required for N self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Database of protein disorder

More...
DisProti
DP00640

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002021 Paramyx_ncap

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00973 Paramyxo_ncap, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q89933-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLLRSLAL FKRNKDKPPI TSGSGGAIRG IKHIIIVPIP GDSSITTRSR
60 70 80 90 100
LLDRLVRLIG NPDVSGPKLT GALIGILSLF VESPGQLIQR ITDDPDVSIR
110 120 130 140 150
LLEVVQSDQS QSGLTFASRG TNMEDEADQY FSHDDPISSD QSRFGWFENK
160 170 180 190 200
EISDIEVQDP EGFNMILGTI LAQIWVLLAK AVTAPDTAAD SELRRWIKYT
210 220 230 240 250
QQRRVVGEFR LERKWLDVVR NRIAEDLSLR RFMVALILDI KRTPGNKPRI
260 270 280 290 300
AEMICDIDTY IVEAGLASFI LTIKFGIETM YPALGLHEFA GELSTLESLM
310 320 330 340 350
NLYQQMGETA PYMVILENSI QNKFSAGSYP LLWSYAMGVG VELENSMGGL
360 370 380 390 400
NFGRSYFDPA YFRLGQEMVR RSAGKVSSTL ASELGITAED ARLVSEIAMH
410 420 430 440 450
TTEDKISRAV GPRQAQVSFL HGDQSENELP RLGGKEDRRV KQSRGEARES
460 470 480 490 500
YRETGPSRAS DARAAHLPTG TPLDIDTASE SSQDPQDSRR SADALLRLQA
510 520
MAGISEEQGS DTDTPIVYND RNLLD
Length:525
Mass (Da):58,131
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C35DF4458769BA0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti58L → S. 1
Natural varianti129Q → K. 1
Natural varianti137I → S. 1
Natural varianti148E → G. 1
Natural varianti262V → G. 1
Natural varianti405K → R. 1
Natural varianti434G → A. 1
Natural varianti448R → G. 1
Natural varianti465A → T. 1
Natural varianti474D → A. 1
Natural varianti478A → V. 1
Natural varianti479S → T. 1
Natural varianti483Q → L. 1
Natural varianti487D → G. 1
Natural varianti493 – 494DA → EP. 2
Natural varianti516I → R. 1
Natural varianti521R → G. 1
Natural varianti522N → D. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z66517 Genomic RNA Translation: CAA91363.1
U03650 Genomic RNA Translation: AAA56640.1
U03653 Genomic RNA Translation: AAA56643.1
U03656 Genomic RNA Translation: AAA56646.1
U03658 Genomic RNA Translation: AAA56648.1
U03661 Genomic RNA Translation: AAA56651.1
U01987 mRNA Translation: AAA18986.1
U01991 mRNA Translation: AAA18990.1
U01992 mRNA Translation: AAA18991.1
U01993 mRNA Translation: AAA18992.1
U01994 mRNA Translation: AAA18993.1
U01996 mRNA Translation: AAA18995.1
AF045218 Genomic RNA Translation: AAC03050.1
AF266286 Genomic RNA Translation: AAF85659.1
AF266288 Genomic RNA Translation: AAF85675.1
AF266289 Genomic RNA Translation: AAF85683.1
AF266290 Genomic RNA Translation: AAF85691.1
AF266291 Genomic RNA Translation: AAF85699.1
AB046218 Genomic RNA Translation: BAB60861.1
AB052821 Genomic RNA Translation: BAB60956.1
AY486083 Genomic RNA Translation: AAR32652.1
AY486084 Genomic RNA Translation: AAR32660.1
AY730614 Genomic RNA Translation: AAV84954.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A49601
PQ0386

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66517 Genomic RNA Translation: CAA91363.1
U03650 Genomic RNA Translation: AAA56640.1
U03653 Genomic RNA Translation: AAA56643.1
U03656 Genomic RNA Translation: AAA56646.1
U03658 Genomic RNA Translation: AAA56648.1
U03661 Genomic RNA Translation: AAA56651.1
U01987 mRNA Translation: AAA18986.1
U01991 mRNA Translation: AAA18990.1
U01992 mRNA Translation: AAA18991.1
U01993 mRNA Translation: AAA18992.1
U01994 mRNA Translation: AAA18993.1
U01996 mRNA Translation: AAA18995.1
AF045218 Genomic RNA Translation: AAC03050.1
AF266286 Genomic RNA Translation: AAF85659.1
AF266288 Genomic RNA Translation: AAF85675.1
AF266289 Genomic RNA Translation: AAF85683.1
AF266290 Genomic RNA Translation: AAF85691.1
AF266291 Genomic RNA Translation: AAF85699.1
AB046218 Genomic RNA Translation: BAB60861.1
AB052821 Genomic RNA Translation: BAB60956.1
AY486083 Genomic RNA Translation: AAR32652.1
AY486084 Genomic RNA Translation: AAR32660.1
AY730614 Genomic RNA Translation: AAV84954.1
PIRiA49601
PQ0386

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E4VX-ray2.71A21-408[»]
SMRiQ89933
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ89933, 1 interactor
MINTiQ89933

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

DisProtiDP00640
InterProiView protein in InterPro
IPR002021 Paramyx_ncap
PfamiView protein in Pfam
PF00973 Paramyxo_ncap, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCAP_MEASF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q89933
Secondary accession number(s): O92927
, Q77M21, Q77M26, Q77M32, Q783Q8, Q83520, Q83523, Q83526, Q83726, Q89890, Q91QN7, Q9IC39
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: July 3, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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