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UniProtKB - Q89905 (Q89905_9VIRU)

Entry version 69 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Envelope polyprotein

Gene

GPC

Organism
Sin Nombre orthohantavirus
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virusARBA annotation, Viral immunoevasion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Envelope polyproteinUniRule annotation
Alternative name(s):
M polyproteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSin Nombre orthohantavirusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1980491 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Negarnaviricota › Polyploviricotina › Ellioviricetes › Bunyavirales › Hantaviridae › Mammantavirinae › Orthohantavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000167429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000204632 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei486 – 510HelicalSequence analysisAdd BLAST25
Transmembranei631 – 650HelicalSequence analysisAdd BLAST20
Transmembranei1109 – 1130HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host endoplasmic reticulumARBA annotation, Host Golgi apparatusARBA annotation, Host membraneARBA annotation, Membrane, VirionUniRule annotationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini615 – 638ITAMInterPro annotationAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hantavirus envelope glycoprotein family.UniRule annotationARBA annotation

Keywords - Domaini

SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016402, Envelope_glycoprot_Hantavirus
IPR002534, Hanta_G1
IPR002532, Hanta_G2
IPR012316, ITAM_motif_hantavir-typ

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01567, Hanta_G1, 1 hit
PF01561, Hanta_G2, 1 hit
PF10538, ITAM_Cys-rich, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF003945, M_poly_HantaV, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51056, ITAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q89905-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGWVCIFLV VLTTATAGLT RNLYELKIEC PHTVGLGQGY VTGSVEITPI 
        60         70         80         90        100
LLTQVADLKI ESSCNFDLHV PATTTQKYNQ VDWTKKSSTT ESTNAGATTF 
       110        120        130        140        150
EAKTKEINLK GTCNIPPTTF EAAYKSRKTV ICYDLACNQT HCLPTVHLIA 
       160        170        180        190        200
PVQTCMSVRS CMIGLLSSRI QVIYEKTYCV TGQLIEGLCF IPTHTIALTQ 
       210        220        230        240        250
PGHTYDTMTL PVTCFLVAKK LGTQLKLAVE LEKLITGVSC TENSFQGYYI 
       260        270        280        290        300
CFIGKHSEPL FVPTMEDYRS AELFTRMVLN PRGEDHDPDQ NGQGLMRIAG 
       310        320        330        340        350
PVTAKVPSTE TTETMQGIAF AGAPMYSSFS TLVRKADPEY VFSPGIIAES 
       360        370        380        390        400
NHSVCDKKTV PLTWTGFLAV SGEIEKITGC TVFCTLAGPG ASCEAYSETG 
       410        420        430        440        450
IFNISSPTCL VNKVQKFRGS EQRINFMCQR VDQDVVVYCN GQKKVILTKT 
       460        470        480        490        500
LVIGQCIYTF TSLFSLIPGV AHSLAVELCV PGLHGWATTA LLITFCFGWL 
       510        520        530        540        550
LIPAVTLIIL KILRLLTFSC SHYSTESKFK VILERVKVEY QKTMGSMVCD 
       560        570        580        590        600
ICHHECETAK ELETHKKSCP EGQCPYCMTI TESTESALQA HFAICKLTNR 
       610        620        630        640        650
FQENLKKSLK RPEVRKGCYR TLGVFRYKSR CYVGLVWGIL LTTELIIWAA 
       660        670        680        690        700
SADTPLMESG WSDTAHGVGI IPMKTDLELD FALASSSSYS YRRKLVNPAN 
       710        720        730        740        750
QEETLPFHFQ LDKQVVHAEI QNLGHWMDGT FNIKTAFHCY GECKKYAYPW 
       760        770        780        790        800
QTAKCFFEKD YQYETSWGCN PPDCPGVGTG CTACGVYLDK LRSVGKAYKI 
       810        820        830        840        850
VSLKYTRKVC IQLGTEQTCK HIDVNDCLVT PSVKVCMIGT ISKLQPGDTL 
       860        870        880        890        900
LFLGPLEQGG IILKQWCTTS CVFGDPGDIM STTSGMRCPE HTGSFRKICG 
       910        920        930        940        950
FATTPTCEYQ GNTVSGFQRM MATRDSFQSF NVTEPHITSN RLEWIDPDSS 
       960        970        980        990       1000
IKDHINMVLN RDVSFQDLSD NPCKVDLHTQ SIDGAWGSGV GFTLVCTVGL 
      1010       1020       1030       1040       1050
TECANFITSI KACDSAMCYG ATVTNLLRGS NTVKVVGKGG HSGSLFKCCH 
      1060       1070       1080       1090       1100
DTDCTEEGLA ASPPHLDRVT GYNQIDSDKV YDDGAPPCTI KCWFTKSGEW 
      1110       1120       1130       1140
LLGILNGNWV VVAVLIVILI LSILLFSFFC PVRSRKNKAN
Length:1,140
Mass (Da):125,735
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4678FD536AB7DBC0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L25783 Viral cRNA Translation: AAA75530.1
L37903 Genomic RNA Translation: AAC42202.1

NCBI Reference Sequences

More...RefSeqi		NP_941974.1, NC_005215.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2654026

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:2654026

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25783 Viral cRNA Translation: AAA75530.1
L37903 Genomic RNA Translation: AAC42202.1
RefSeqiNP_941974.1, NC_005215.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi2654026
KEGGivg:2654026

Family and domain databases

InterProiView protein in InterPro
IPR016402, Envelope_glycoprot_Hantavirus
IPR002534, Hanta_G1
IPR002532, Hanta_G2
IPR012316, ITAM_motif_hantavir-typ
PfamiView protein in Pfam
PF01567, Hanta_G1, 1 hit
PF01561, Hanta_G2, 1 hit
PF10538, ITAM_Cys-rich, 1 hit
PIRSFiPIRSF003945, M_poly_HantaV, 1 hit
PROSITEiView protein in PROSITE
PS51056, ITAM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ89905_9VIRU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q89905
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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