UniProtKB - Q89828 (VL1_COPV6)
Major capsid protein L1
L1
Functioni
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
UniRule annotationGO - Molecular functioni
- structural molecule activity Source: UniProtKB-UniRule
GO - Biological processi
- endocytosis involved in viral entry into host cell Source: UniProtKB-KW
- virion attachment to host cell Source: UniProtKB-UniRule
Keywordsi
Biological process | Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell |
Names & Taxonomyi
Protein namesi | Recommended name: Major capsid protein L1UniRule annotation |
Gene namesi | Name:L1UniRule annotation |
Organismi | Canine oral papillomavirus (strain Y62) (COPV) |
Taxonomic identifieri | 766192 [NCBI] |
Taxonomic lineagei | Viruses › Monodnaviria › Shotokuvirae › Cossaviricota › Papovaviricetes › Zurhausenvirales › Papillomaviridae › Firstpapillomavirinae › Lambdapapillomavirus › |
Virus hosti | Canis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615] |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
Keywords - Cellular componenti
Capsid protein, Host nucleus, T=7 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000133555 | 1 – 503 | Major capsid protein L1Add BLAST | 503 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 178 | Interchain (with C-431)UniRule annotation | ||
Disulfide bondi | 431 | Interchain (with C-178)UniRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PRIDEi | Q89828 |
Interactioni
Subunit structurei
Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1.
Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation.
Interacts with protein E2; this interaction enhances E2-dependent replication and transcription activation.
UniRule annotationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 270 – 289 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 2.60.175.20, 2 hits |
HAMAPi | MF_04002, PPV_L1, 1 hit |
InterProi | View protein in InterPro IPR002210, Capsid_L1_Papillomavir IPR036973, Capsid_L1_sf_Papillomavir IPR011222, dsDNA_vir_gr_I_capsid |
Pfami | View protein in Pfam PF00500, Late_protein_L1, 1 hit |
PRINTSi | PR00865, HPVCAPSIDL1 |
SUPFAMi | SSF88648, SSF88648, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAVWLPAQNK FYLPPQPSTK VLSTDEYVSR TNIFYHASSE RLLTVGHPFY
60 70 80 90 100
EIYKEERSEE VIVPKVSPNQ YRVFRLLLPD PNNFAFGDKS LFDPEKERLV
110 120 130 140 150
WGLRGLEIGR GQPLGISVTG HPTFDRYNDV ENPNKNLAGH GGGTDSRVNM
160 170 180 190 200
GLDPKQTQMF MIGCKPALGE HWSLTRWCTG QVHTAGQCPP IELRNTTIED
210 220 230 240 250
GDMVDIGFGA MDFKALQHYK SGVPIDIVNS ACKYPDYLKM ANEPYGDRCF
260 270 280 290 300
FFVRREQLYA RHIMSRSGTQ GLEPVPKDTY ATREDNNIGT TNYFSTPSGS
310 320 330 340 350
LVSSEGQLFN RPYWIQRSQG KNNGIAWGNQ LFLTVVDNTR GTPLTINIGQ
360 370 380 390 400
QDKPEEGNYV PSSYRTYLRH VEEYEVSIIV QLCKVKLSPE NLAIIHTMDP
410 420 430 440 450
NIIEDWHLNV TPPSGTLDDT YRYINSLATK CPTNIPPKTN VDPFADFKFW
460 470 480 490 500
EVDLKDKMTE QLDQTPLGRK FLFQTNVLRP RSVKVRSTSH VSVKRKAVKR
KRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D55633 Genomic DNA Translation: BAA09503.1 D26115 Genomic DNA Translation: BAA05111.1 L22695 Genomic DNA Translation: AAA61750.1 |
RefSeqi | NP_056819.1, NC_001619.1 |
Genome annotation databases
GeneIDi | 1497245 |
KEGGi | vg:1497245 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D55633 Genomic DNA Translation: BAA09503.1 D26115 Genomic DNA Translation: BAA05111.1 L22695 Genomic DNA Translation: AAA61750.1 |
RefSeqi | NP_056819.1, NC_001619.1 |
3D structure databases
SMRi | Q89828 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q89828 |
Genome annotation databases
GeneIDi | 1497245 |
KEGGi | vg:1497245 |
Family and domain databases
Gene3Di | 2.60.175.20, 2 hits |
HAMAPi | MF_04002, PPV_L1, 1 hit |
InterProi | View protein in InterPro IPR002210, Capsid_L1_Papillomavir IPR036973, Capsid_L1_sf_Papillomavir IPR011222, dsDNA_vir_gr_I_capsid |
Pfami | View protein in Pfam PF00500, Late_protein_L1, 1 hit |
PRINTSi | PR00865, HPVCAPSIDL1 |
SUPFAMi | SSF88648, SSF88648, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VL1_COPV6 | |
Accessioni | Q89828Primary (citable) accession number: Q89828 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families