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UniProtKB - Q895K2 (DPO3_CLOTE)

Entry version 119 (23 Feb 2022)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

DNA polymerase III PolC-type

Gene

polC

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		CTET212717:G1G04-1306-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III PolC-typeUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
PolIIIUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:CTC_01271
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridium tetani (strain Massachusetts / E88)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri212717 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Clostridia › Eubacteriales › Clostridiaceae › Clostridium ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001412 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002045761 – 1427DNA polymerase III PolC-typeAdd BLAST1427

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		212717.CTC_01271

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q895K2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini413 – 568ExonucleaseAdd BLAST156

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. PolC subfamily.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003297_2_0_9

Identification of Orthologs from Complete Genome Data

More...OMAi		YYAAYFT

Database of Orthologous Groups

More...OrthoDBi		561611at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.700, 2 hits
3.30.420.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00356, DNApol_PolC, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR024754, DNA_PolC-like_N_II
IPR029460, DNAPol_HHH
IPR006054, DnaQ
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR012340, NA-bd_OB-fold
IPR004365, NA-bd_OB_tRNA
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR006308, PolC_gram_pos
IPR044923, PolC_middle_finger_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11490, DNA_pol3_a_NII, 1 hit
PF07733, DNA_pol3_alpha, 1 hit
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
PF00929, RNase_T, 1 hit
PF01336, tRNA_anti-codon, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00479, EXOIII, 1 hit
SM00481, POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 1 hit
SSF53098, SSF53098, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00573, dnaq, 1 hit
TIGR01405, polC_Gram_pos, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q895K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELAKILEDN TFSQDSLEGI RVHRIQYFKK SNKLKVIVKS KKEVNNNQIT 
        60         70         80         90        100
EIKKVFFKKF QYFKEIEVLS YRDVSGINLK DICEKYWIDI VNSILTYIPF 
       110        120        130        140        150
CKECLISSKR KVIDENTLKL QYGNDFLYNI LKEKNFEKIL SSTIKDVFGV 
       160        170        180        190        200
ECKVKFILDK SNGKCNYLDF KEEQEALIIK NIIKESRIEK TIPKKDNNYN 
       210        220        230        240        250
KREENKNSSI IVGKNINEDP VDISNIDETS GIISICGDVF KTKIIETKTG 
       260        270        280        290        300
RKIVTFYITD YTSSITVKLF PKPKDTERVI EEIKEGLYCK IRGEVVNDSY 
       310        320        330        340        350
AREIVIMARD IVKLNKIEKM DIAEEKRVEL HLHTKMSAMD GMNSAESLIK 
       360        370        380        390        400
RAAKWGHKAV AITDHGVVQA YPEAMEAAKK YNIKIIYGVE GYLVDDGIPI 
       410        420        430        440        450
AINAGHRTLE DSYVVFDIET TGFSNKNDKI IEIGAVKIKE GKVVDKYSTF 
       460        470        480        490        500
VNPERIIPEK IIELTGIHDY MVKDAPKIEE VLPKFIDFIE DSILVAHNAN 
       510        520        530        540        550
FDVSFIKKNC KDFGIHFNNP ILDTIPLCKF LYPELKRYKL NVVAKHLGIP 
       560        570        580        590        600
LLNHHRAVED AKTTGDILLK AFEDLKDKEI MNLNMLNEEY FKNQDIKKSP 
       610        620        630        640        650
TYHVIILVKN KIGLKNLYKL ISESHLNHFY KKPRMPKSLI NKYREGLMIG 
       660        670        680        690        700
SACEAGQVYK EVLMDKSKEE LKEVISFYDY LEIQPIKNNY FMIRNGIVKD 
       710        720        730        740        750
EEELRDINKK IYNLAEENNM PVVATCDVHF LDKKDEVFRK ILMAGQGFSD 
       760        770        780        790        800
AENQPPLYLR TTDEMLKEFE YLGKEKAYKA VVTNTVKIAD SIDNIKPIPD 
       810        820        830        840        850
ETFPPKIEGS EEEVRKMTIE KAHSIYGEVL PEIVEKRLEK ELNSIINNGY 
       860        870        880        890        900
AVLYLIAHKL VDKSVQDGYL VGSRGSVGSS LVATMTDITE VNGLPPHYVC 
       910        920        930        940        950
PGCKYNEFIT DGSVSSGADL PDKNCPNCGV LLSKDGHDIP FETFLGFEGD 
       960        970        980        990       1000
KEPDIDLNFS GEYQAVVHKY TEVLFGEGKV FKAGTIGTIA EKTAYGFVKK 
      1010       1020       1030       1040       1050
YISEKDLNVR QAEIERLTLG CSGVKRTTGQ HPGGIMVVPQ DNEIFNFTPI 
      1060       1070       1080       1090       1100
QRPADDNDTD IITTHFDYHS ISGRLLKLDI LGHDDPTVLR MLQDLTGVDP 
      1110       1120       1130       1140       1150
KKIPLADPKV MSLFTSPKAL GVNAEELKCE VGTYGLPEFG TKFVRQMLVD 
      1160       1170       1180       1190       1200
TQPNSFSDLV RISGLSHGTD VWLNNAQYYI KEGYTTLKDC IATRDDIMTY 
      1210       1220       1230       1240       1250
LIQKDLPPKI AFTIMEKVRK GKGLTEEHEA IMREHDVPGW YIESCKKIKY 
      1260       1270       1280       1290       1300
MFPKGHAVAY VMMAVRIAYF KVYYPTAYYA TYFSVRASDF DAETVFKGEE 
      1310       1320       1330       1340       1350
AILNKIDEIN SLGNNVTQKD KGLLTVLEIC HEMNLRGIKF LKADLYKSNA 
      1360       1370       1380       1390       1400
SKFLIEEEGI RIPLSAIQGV GENAAKNIVE AREEGEFISK EDLNKRGKAT 
      1410       1420 
KTVIENLENH GCLRGLPESN QLSLFNL
Length:1,427
Mass (Da):162,360
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23D6582BF9FAD4CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE015927 Genomic DNA Translation: AAO35838.1

NCBI Reference Sequences

More...RefSeqi		WP_011099500.1, NC_004557.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAO35838; AAO35838; CTC_01271

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64179060

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ctc:CTC_01271

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA Translation: AAO35838.1
RefSeqiWP_011099500.1, NC_004557.1

3D structure databases

SMRiQ895K2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi212717.CTC_01271

Genome annotation databases

EnsemblBacteriaiAAO35838; AAO35838; CTC_01271
GeneIDi64179060
KEGGictc:CTC_01271

Phylogenomic databases

HOGENOMiCLU_003297_2_0_9
OMAiYYAAYFT
OrthoDBi561611at2

Enzyme and pathway databases

BioCyciCTET212717:G1G04-1306-MONOMER

Family and domain databases

Gene3Di1.10.150.700, 2 hits
3.30.420.10, 1 hit
HAMAPiMF_00356, DNApol_PolC, 1 hit
InterProiView protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR024754, DNA_PolC-like_N_II
IPR029460, DNAPol_HHH
IPR006054, DnaQ
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR012340, NA-bd_OB-fold
IPR004365, NA-bd_OB_tRNA
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR006308, PolC_gram_pos
IPR044923, PolC_middle_finger_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF11490, DNA_pol3_a_NII, 1 hit
PF07733, DNA_pol3_alpha, 1 hit
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
PF00929, RNase_T, 1 hit
PF01336, tRNA_anti-codon, 1 hit
SMARTiView protein in SMART
SM00479, EXOIII, 1 hit
SM00481, POLIIIAc, 1 hit
SUPFAMiSSF50249, SSF50249, 1 hit
SSF53098, SSF53098, 1 hit
TIGRFAMsiTIGR00573, dnaq, 1 hit
TIGR01405, polC_Gram_pos, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPO3_CLOTE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q895K2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: June 1, 2003
Last modified: February 23, 2022
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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