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Protein

Protein Vpr

Gene

vpr

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus. This function is crucial for viral infection of non-dividing macrophages. May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.UniRule annotation
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotationSAAS annotation
Biological processCell cycleUniRule annotationSAAS annotation, Host-virus interactionUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation, Viral penetration into host nucleusUniRule annotationSAAS annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VprUniRule annotationSAAS annotation
Alternative name(s):
Viral protein RUniRule annotation
Gene namesi
Name:vprUniRule annotationImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host nucleus UniRule annotationSAAS annotation
  • Virion UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotationSAAS annotation, VirionUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ89588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

HAMAPiMF_04080 HIV_VPR, 1 hit
InterProiView protein in InterPro
IPR000012 RetroV_VpR/X
PfamiView protein in Pfam
PF00522 VPR, 1 hit
PRINTSiPR00444 HIVVPRVPX

Sequencei

Sequence statusi: Complete.

Q89588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQAPEDQGP QREPYNEWAL ELLEDLKTEA VRHFPRIWLH SLGQHIYETY
60 70 80 90
GDTWTGVEAI IRILQQLLFI HFRIGCQHSR IGITPQRRRA RNGASRS
Length:97
Mass (Da):11,435
Last modified:November 1, 1996 - v1
Checksum:iA1399856DB2FD52A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41721 Genomic DNA Translation: AAA87877.1
U61912 Genomic DNA Translation: AAB05510.1

Similar proteinsi

Entry informationi

Entry nameiQ89588_9HIV1
AccessioniPrimary (citable) accession number: Q89588
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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