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Protein

CD2 homolog

Gene

Ba71V-058

Organism
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an immunosuppressive role by inhibiting lymphocyte proliferation and subsequently facilitating viral replication and generalization of infection (By similarity). Responsible for viral hemadsorption, which may help viral spread (PubMed:8102411, PubMed:8615037). Increases virus replication in the tick vector at the step of virus uptake or replication in the tick gut (PubMed:19729182). May play a role in the host Golgi reorganization to yield viral factories (PubMed:25915900).By similarity4 Publications

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
CD2 homolog
Short name:
CD2H
Alternative name(s):
5HL
CD2v
PEP402R
T-lymphocyte CD2 receptor-like protein
Short name:
CD2-like protein
Gene namesi
Ordered Locus Names:Ba71V-058
ORF Names:EP402R
OrganismiAfrican swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Taxonomic identifieri10498 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostiOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000000624 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 204ExtracellularSequence analysisAdd BLAST188
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 402CytoplasmicSequence analysisAdd BLAST177

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000037909217 – 402CD2 homologAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi52N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi72N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Disulfide bondi126 ↔ 191By similarity
Disulfide bondi133 ↔ 174By similarity
Glycosylationi137N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi153N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Post-translational modificationi

Cleaved into two fragments of 63 kDa and 26 kDa containing respectively the glycosylated N-terminus and the nonglycosylated C-terminus.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Inductioni

Expressed late in the infection cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Both glycosylated and nonglycosylated forms interact (via C-terminus) with the host AP-1 complex.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ89501
SMRiQ89501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi208 – 230Ile-richPROSITE-ProRule annotationAdd BLAST23
Compositional biasi265 – 387Pro-richPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000WM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q89501-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIIIVIFLMC LKIVLNNIII WSTLNQTVFL NNIFTINDTY GGLFWNTYYD
60 70 80 90 100
NNRSNFTYCG IAGNYCSCCG HNISLYNTTN NCSLIIFPNN TEIFNRTYEL
110 120 130 140 150
VYLDKKINYT VKLLKSVDSP TITYNCTNSL ITCKNNNGTN VNIYLIINNT
160 170 180 190 200
IVNDTNGDIL NYYWNGNNNF TATCMINNTI SSLNETENIN CTNPILKYQN
210 220 230 240 250
YLSTLFYIII FIVSGLIIGI FISIISVLSI RRKRKKHVEE IESPPPSESN
260 270 280 290 300
EEDISHDDTT SIHEPSPREP LLPKPYSRYQ YNTPIYYMRP STQPLNPFPL
310 320 330 340 350
PKPCPPPKPC PPPKPCPPPK PCPPPKPCSP PKPCRPPKPC PPPKPCPPPK
360 370 380 390 400
PCPPPKPCPP SKPCPSPESY SPPKPLPSIP LLPNIPPLST QNISLIHVDR

II
Length:402
Mass (Da):45,325
Last modified:November 1, 1996 - v1
Checksum:iB8C18BE6C5C6BE04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18466 Genomic DNA Translation: AAA65288.1
PIRiA40678
RefSeqiNP_042752.1, NC_001659.2

Genome annotation databases

GeneIDi22220440
KEGGivg:22220440

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18466 Genomic DNA Translation: AAA65288.1
PIRiA40678
RefSeqiNP_042752.1, NC_001659.2

3D structure databases

ProteinModelPortaliQ89501
SMRiQ89501
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi1488823
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22220440
KEGGivg:22220440

Phylogenomic databases

OrthoDBiVOG090000WM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD2H_ASFB7
AccessioniPrimary (citable) accession number: Q89501
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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